全文获取类型
收费全文 | 8589篇 |
免费 | 589篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 66篇 |
儿科学 | 364篇 |
妇产科学 | 293篇 |
基础医学 | 1014篇 |
口腔科学 | 181篇 |
临床医学 | 865篇 |
内科学 | 1773篇 |
皮肤病学 | 218篇 |
神经病学 | 659篇 |
特种医学 | 246篇 |
外国民族医学 | 7篇 |
外科学 | 1169篇 |
综合类 | 178篇 |
一般理论 | 5篇 |
预防医学 | 781篇 |
眼科学 | 219篇 |
药学 | 613篇 |
中国医学 | 36篇 |
肿瘤学 | 537篇 |
出版年
2023年 | 90篇 |
2022年 | 154篇 |
2021年 | 348篇 |
2020年 | 229篇 |
2019年 | 269篇 |
2018年 | 355篇 |
2017年 | 250篇 |
2016年 | 262篇 |
2015年 | 255篇 |
2014年 | 390篇 |
2013年 | 498篇 |
2012年 | 674篇 |
2011年 | 708篇 |
2010年 | 380篇 |
2009年 | 298篇 |
2008年 | 483篇 |
2007年 | 542篇 |
2006年 | 466篇 |
2005年 | 537篇 |
2004年 | 402篇 |
2003年 | 358篇 |
2002年 | 300篇 |
2001年 | 98篇 |
2000年 | 78篇 |
1999年 | 92篇 |
1998年 | 43篇 |
1997年 | 51篇 |
1996年 | 32篇 |
1995年 | 41篇 |
1994年 | 27篇 |
1993年 | 34篇 |
1992年 | 33篇 |
1991年 | 23篇 |
1990年 | 30篇 |
1989年 | 31篇 |
1988年 | 25篇 |
1987年 | 21篇 |
1986年 | 27篇 |
1985年 | 28篇 |
1984年 | 17篇 |
1983年 | 16篇 |
1982年 | 20篇 |
1981年 | 14篇 |
1980年 | 15篇 |
1979年 | 14篇 |
1978年 | 23篇 |
1976年 | 14篇 |
1972年 | 15篇 |
1971年 | 11篇 |
1969年 | 16篇 |
排序方式: 共有9224条查询结果,搜索用时 15 毫秒
1.
2.
3.
Aziz Sheikh Samantha Walker 《英国医学杂志》2006,9(3):186-186
A 60 year old man attends to discuss his recent allergic reaction to an insect sting. He presents you with the casualty letter which reads : " Treated for anaphylaxis after bee sting-see GP for follow-up. " 相似文献
4.
Cough and paradoxical vocal fold motion 总被引:8,自引:0,他引:8
Kenneth W. Altman MD PhD C. Blake Simpson MD Milan R. Amin MD Mona Abaza MD Ron Balkissoon MD Roy R. Casiano MD 《Otolaryngology--head and neck surgery》2002,127(6):501-511
OBJECTIVES: The differential diagnosis and treatment of patients with chronic cough, paradoxical vocal fold motion, and disordered breathing can be a challenge to most practicing otolaryngologists. Tracheobronchial (ie, asthma, bronchitis, and tracheal stenosis), laryngeal (ie, vocal fold paralysis and neoplasms), and rhinologic (ie, allergies and rhinosinusitis) etiologies are commonly diagnosed and treated effectively. However, occasionally one is faced with patients who are refractory to medical treatment and have no obvious rhinologic, laryngeal or pulmonary cause. STUDY DESIGN AND SETTING: We conducted a review of the literature. METHODS: We present a thorough review of the current medical literature exploring the complex neurologic mechanisms involved in the production of cough and the relationship between gastroesophageal reflux disease, vagal neurapathy, and paradoxical vocal fold motion. RESULTS: The diagnosis and successful treatment of chronic cough can be complex. It requires a thorough understanding of the neurologic mechanisms behind cough excitation and suppression. Successful treatment strategies include aggressive management of the patient's reactive airway disease, gastroesophageal reflux disease, and, in select cases, paradoxical vocal fold motion. This may involve a well-coordinated effort among pulmonologists, otolaryngologists, gastroenterologists, and speech pathologists. CONCLUSION: Gastroesophageal reflux disease, vagal neuropathy, and paradoxical vocal fold motion are additional causes of chronic cough and disordered breathing that need to be considered, in the absence of obvious laryngotracheal and/or rhinologic pathology. A high index of suspicion is essential in making the diagnosis and formulating an effective multidisciplinary treatment plan for these patients. 相似文献
5.
Enyioma N OBINECHE Michael PT GILLETT Abdishakur ABDULLE Mustapha SULAIMAN Mona AL-ROKHAIMI 《Nephrology (Carlton, Vic.)》2002,7(3):115-120
SUMMARY: In patients with chronic renal failure (CRF), hyperleptinaemia has been widely reported, but the exact mechanisms leading to elevated leptin levels are unclear. Impaired renal clearance of leptin and the influence of other hormones may be important. In this study, we measured serum leptin levels in 150 patients on haemodialysis, peritoneal dialysis or in the predialysis phase of CRF. Furthermore, we measured plasma levels of insulin, growth hormone (GH) and insulin-like growth factor 1 (IGF-1), as well as plasma levels of triacylglycerols and total low density lipoprotein (LDL)- and high density lipoprotein (HDL)-cholesterol. We observed significantly elevated levels of leptin, particularly in female patients, and leptin was shown to correlate significantly with insulin, total and LDL-cholesterol and log triacylglycerols. Leptin was inversely correlated with GH concentrations, but was not correlated with IGF-1 levels. Despite the multiple correlations established between leptin levels and other variables, only hyperinsulinaemia in CRF seems to be important as a determinator of leptin levels. 相似文献
6.
Dipankar Nandi Helen Smith Sarah Owen Carole Joint John Stein Tipu Aziz 《Journal of clinical neuroscience》2002,9(5):557-561
Central post stroke pain is often difficult to manage satisfactorily with conventional treatment modalities for pain. In the last decade functional neurosurgery has offered hope with motor cortex stimulation achieving significant alleviation of pain in some patients. Unfortunately this has led to the neglect of chronic stimulation of deep grey matter as another modality of treating this condition. In this article we present our experience with motor cortex stimulation and that with deep grey matter stimulation in patients with post stroke pain. We argue that both modalities have a significant role and that what is required are better methods of identifying particular patients who are more likely to respond to one or the other. 相似文献
7.
8.
9.
10.
Ruhangiz T. Kilani ; Larry Guilbert ; Xiaoyue Lin ; Aziz Ghahary 《Wound repair and regeneration》2007,15(2):236-244
Overexpression of wound healing-promoting factors such as transforming growth factor-1 (TGF-beta1) and insulin-like growth factor-1 (IGF-1) during the healing process has been implicated in the development of dermal fibrosis in patients following thermal injury, surgical incision, and deep trauma. However, the mechanism through which the expression of these two fibrogenic factors is slowed down and/or abrogated in the late stages of the healing process is not known. Here, we hypothesize that keratinocyte-releasable factors counteract the fibrogenic role of both IGF-1 and TGF-beta1 in fibroblasts. To test this hypothesis, the levels of collagenase (MMP-1), as an index for extracellular matrix degradation, in dermal fibroblasts in response to either keratinocyte-conditioned medium (KCM) or our recently identified keratinocyte-releasable stratifin in the presence and absence of either IGF-1, TGF-beta1, or both were evaluated. The results of Northern analysis showed a significant increase in collagenase mRNA expression in cells treated with KCM in the presence of both IGF-1 and TGF-beta1. The effect was, at least in part, due to keratinocyte-derived stratifin that was present in KCM. This was ascertained as the levels of MMP-1 mRNA were markedly reduced when cells were treated with stratifin-immuno-depleted KCM. The results of Western blot analysis showed an increase in the level of MMP-1 protein in stratifin-treated fibroblasts and this was consistent with the level of MMP-1 mRNA expression detected by Northern analysis. However, in contrast to KCM, whose efficacy on MMP-1 expression was modestly reduced by either IGF-1 and TGF-beta1, or a combination of both, these factors abrogated the MMP-1 stimulatory effect of stratifin in fibroblasts. In summary, the results of this study revealed that both stratifin and KCM stimulate the expression of MMP-1-in fibroblasts and this effect can be abrogated by either IGF-1, TGF-beta1, or a combination of both. 相似文献