全文获取类型
收费全文 | 2303篇 |
免费 | 232篇 |
国内免费 | 51篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 182篇 |
妇产科学 | 39篇 |
基础医学 | 229篇 |
口腔科学 | 107篇 |
临床医学 | 216篇 |
内科学 | 585篇 |
皮肤病学 | 53篇 |
神经病学 | 75篇 |
特种医学 | 205篇 |
外科学 | 353篇 |
综合类 | 105篇 |
预防医学 | 167篇 |
眼科学 | 29篇 |
药学 | 110篇 |
中国医学 | 5篇 |
肿瘤学 | 96篇 |
出版年
2023年 | 22篇 |
2022年 | 28篇 |
2021年 | 69篇 |
2020年 | 40篇 |
2019年 | 38篇 |
2018年 | 38篇 |
2017年 | 60篇 |
2016年 | 56篇 |
2015年 | 55篇 |
2014年 | 98篇 |
2013年 | 110篇 |
2012年 | 82篇 |
2011年 | 89篇 |
2010年 | 106篇 |
2009年 | 96篇 |
2008年 | 81篇 |
2007年 | 121篇 |
2006年 | 85篇 |
2005年 | 73篇 |
2004年 | 71篇 |
2003年 | 52篇 |
2002年 | 50篇 |
2001年 | 56篇 |
2000年 | 40篇 |
1999年 | 50篇 |
1998年 | 88篇 |
1997年 | 73篇 |
1996年 | 71篇 |
1995年 | 56篇 |
1994年 | 55篇 |
1993年 | 46篇 |
1992年 | 26篇 |
1991年 | 26篇 |
1990年 | 45篇 |
1989年 | 33篇 |
1988年 | 43篇 |
1987年 | 32篇 |
1986年 | 36篇 |
1985年 | 27篇 |
1984年 | 22篇 |
1983年 | 22篇 |
1982年 | 13篇 |
1980年 | 13篇 |
1979年 | 22篇 |
1978年 | 16篇 |
1976年 | 21篇 |
1975年 | 17篇 |
1973年 | 13篇 |
1969年 | 16篇 |
1968年 | 11篇 |
排序方式: 共有2586条查询结果,搜索用时 15 毫秒
1.
2.
3.
PINK1 mutations in sporadic early-onset Parkinson's disease. 总被引:5,自引:0,他引:5
Eng-King Tan Kenneth Yew Eva Chua K Puvan Hui Shen Esther Lee Kim-Yoong Puong Yi Zhao Ratnagopal Pavanni Meng-Cheong Wong Dominic Jamora Deidre de Silva Kyaw-Thu Moe Fung-Peng Woon Yih Yuen Louis Tan 《Movement disorders》2006,21(6):789-793
Pathogenic PINK1 mutations have been described in PARK6-linked Parkinson's disease (PD) patients of Asian origin. However, data on the frequency of PINK1 mutations in sporadic early-onset Parkinson's disease (EOPD) Asian patients are lacking. The objectives of this study were to report the frequency of PINK1 mutations of sporadic EOPD in an Asian cohort comprising of ethnic Chinese, Malays, and Indians, and to highlight a PINK1-positive patient who presented with restless legs symptoms. Eighty consecutive sporadic EOPD patients from the movement disorder clinics of two major tertiary institutions in the country were included. We performed sequence analysis of all the coding and exon-intron junctions of the PINK1 using specific primer sets. In addition, we genotyped polymorphisms detected from the analysis in a group of sporadic PD patients and controls. Three different mutations (two homozygous nonsense and one heterozygous missense) in the putative kinase domain were found in three patients, giving a 3.7% frequency of PINK1 mutations in our EOPD cohort. All the mutations were absent in 200 healthy controls. One patient with a novel homozygous nonsense PINK1 mutation presented unusually with restless legs symptoms. Separately, analysis of the frequency of four PINK1 polymorphisms in a group of sporadic PD and controls did not reveal any significant differences. We highlight a 3.7% frequency of PINK1 mutations in an Asian cohort (ethnic Chinese, Malay, and Indian) of EOPD. The phenotypic spectrum associated with PINK1-positive patients may be wider than previously reported. Polymorphisms of PINK1 do not appear to modulate risk of PD in our population. 相似文献
4.
By injecting small amounts of CO2 through a needle, one can move bowel or bladder from the intended path of instruments during interventional procedures. The technique worked well in six of seven cases in the pelvis and retroperitoneum; it was not effective in the mediastinum or midabdomen (n = 6). 相似文献
5.
Tori Smedal Hildegunn Lygren Kjell‐Morten Myhr Rolf Moe‐Nilssen Bente Gjelsvik Olav Gjelsvik Liv Inger Strand 《Physiotherapy research international》2006,11(2):104-116
Background and Purpose . Patients with multiple sclerosis (MS) tend to have movement difficulties, and the effect of physiotherapy for this group of patients has been subjected to limited systematic research. In the present study physiotherapy based on the Bobath concept, applied to MS patients with balance and gait problems, was evaluated. The ability of different functional tests to demonstrate change was evaluated. Method . A single‐subject experimental study design with ABAA phases was used, and two patients with relapsing–remitting MS in stable phase were treated. Tests were performed 12 times, three at each phase: A (at baseline); B (during treatment); A (immediately after treatment); and A (after two months). The key feature of treatment was facilitation of postural activity and selective control of movement. Several performance and self‐report measures and interviews were used. Results . After intervention, improved balance was shown by the Berg Balance Scale (BBS) in both patients, and improved quality of gait was indicated by the Rivermead Visual Gait Assessment (RVGA). The patients also reported improved balance and gait function in the interviews and scored their condition as ‘much improved’. Gait parameters, recorded by an electronic walkway, changed, but differently in the two patients. Among the physical performance tests the BBS and the RVGA demonstrated the highest change, while no or minimal change was demonstrated by the Rivermead Mobility Index (RMI) and Ratings of Perceived Exertion (RPE). Conclusion . The findings indicate that balance and gait can be improved after physiotherapy based on the Bobath concept, but this should be further evaluated in larger controlled trials of patients with MS. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
6.
外科医生和手术室人员经常接触手术设备产生的烟气,病人也会暴露于烟气中,特别是腹腔镜手术中产生的烟气滞留于腹腔内这一密闭空间并被吸收.这些烟气是一种与香烟烟气相似的毒性物质,然而对这种毒性物质的影响还未引起足够重视.应该采取必要措施尽可能减少手术中烟气的不良影响. 相似文献
7.
8.
9.
10.