全文获取类型
收费全文 | 693篇 |
免费 | 43篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 10篇 |
妇产科学 | 35篇 |
基础医学 | 76篇 |
口腔科学 | 9篇 |
临床医学 | 52篇 |
内科学 | 173篇 |
皮肤病学 | 8篇 |
神经病学 | 75篇 |
特种医学 | 12篇 |
外科学 | 156篇 |
综合类 | 4篇 |
预防医学 | 30篇 |
眼科学 | 3篇 |
药学 | 53篇 |
肿瘤学 | 46篇 |
出版年
2023年 | 4篇 |
2022年 | 4篇 |
2021年 | 13篇 |
2020年 | 8篇 |
2019年 | 13篇 |
2018年 | 19篇 |
2017年 | 12篇 |
2016年 | 22篇 |
2015年 | 12篇 |
2014年 | 26篇 |
2013年 | 45篇 |
2012年 | 68篇 |
2011年 | 57篇 |
2010年 | 20篇 |
2009年 | 15篇 |
2008年 | 39篇 |
2007年 | 30篇 |
2006年 | 39篇 |
2005年 | 33篇 |
2004年 | 49篇 |
2003年 | 34篇 |
2002年 | 26篇 |
2001年 | 13篇 |
2000年 | 8篇 |
1999年 | 6篇 |
1998年 | 8篇 |
1997年 | 7篇 |
1996年 | 7篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 7篇 |
1988年 | 3篇 |
1987年 | 5篇 |
1986年 | 3篇 |
1985年 | 11篇 |
1984年 | 8篇 |
1982年 | 3篇 |
1980年 | 2篇 |
1978年 | 7篇 |
1977年 | 7篇 |
1975年 | 6篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1968年 | 2篇 |
1966年 | 2篇 |
排序方式: 共有743条查询结果,搜索用时 375 毫秒
1.
Attila Patocs Peter Gergics Katalin Balogh Miklos Toth Ferenc Fazakas Istvan Liko Karoly Racz 《BMC medical genetics》2008,9(1):29
Von Hippel-Lindau disease (VHL) is a rare autosomal dominant disease characterized by development of cystic and tumorous lesions
at multiple sites, including the brain, spinal cord, kidneys, adrenals, pancreas, epididymis and eyes. The clinical phenotype
results from molecular abnormalities of the VHL tumor suppressor gene, mapped to human chromosome 3p25-26. The VHL gene encodes two functionally active VHL proteins due to the presence of two translational initiation sites separated by
53 codons. The majority of disease-causing mutations have been detected downstream of the second translational initiation
site, but there are conflicting data as to whether few mutations located in the first 53 codons, such as the Pro25Leu could
have a pathogenic role. In this paper we report a large Hungarian VHL type 2 family consisting of 32 members in whom a disease-causing
AGT80AAT (Ser80Ile) c.239G>A, p.Ser80Ile mutation, but not the concurrent CCT25CTT (Pro25Leu) c.74C>T, p.Pro25Leu variant
co-segregated with the disease. To our knowledge, the Ser80Ile mutation has not been previously described in VHL type 2 patients
with high risk of pheochromocytoma and renal cell cancer. Therefore, this finding represents a novel genotype-phenotype association
and VHL kindreds with Ser80Ile mutation will require careful surveillance for pheochromocytoma. We concluded that the Pro25Leu
variant is a rare, neutral variant, but the presence such a rare gene variant may make genetic counseling difficult. 相似文献
2.
Miklos Degré Geir Bukholm Ellen E. Lund Gisle Djupesland 《Medical microbiology and immunology》1978,166(1-4):151-156
Herpes virus hominis type 1 was isolated from the trigeminal ganglion (ganglion semilunare, gasservian) in three out of 20 randomly selected autopsies. Two of the three patients had been treated with immunosuppressive or cytostatic agents. Clinical signs of herpes infection were not observed during the previous 6 months. No virus was isolated from the facial ganglion (geniculate ganglion) in the same 20 cases. The findings are discussed in relation to the viral etiology of acute peripheral facial palsy. 相似文献
3.
4.
Tarek Alhamad Michelle Lubetzky Krista L. Lentine Emmanuel Edusei Ronald Parsons Martha Pavlakis Kenneth J. Woodside Deborah Adey Christopher D. Blosser Beatrice P. Concepcion John Friedewald Alexander Wiseman Neeraj Singh Su-Hsin Chang Gaurav Gupta Miklos Z. Molnar Arpita Basu Edward Kraus Song Ong Arman Faravardeh Ekamol Tantisattamo Leonardo Riella Jim Rice Darshana M. Dadhania 《American journal of transplantation》2021,21(9):3034-3042
Kidney allograft failure and return to dialysis carry a high risk of morbidity. A practice survey was developed by the AST Kidney Pancreas Community of Practice workgroup and distributed electronically to the AST members. There were 104 respondents who represented 92 kidney transplant centers. Most survey respondents were transplant nephrologists at academic centers. The most common approach to immunosuppression management was to withdraw the antimetabolite first (73%), while only 12% responded they would withdraw calcineurin inhibitor (CNI) first. More than 60% reported that the availability of a living donor is the most important factor in their decision to taper immunosuppression, followed by risk of infection, risk of sensitization, frailty, and side effects of medications. More than half of respondents reported that embolization was either not available or offered to less than 10% as an option for surgical intervention. Majority reported that ≤50% of failed allograft patients were re-listed before dialysis, and less than a quarter of transplant nephrologists performed frequent visits with their patients with failed kidney allograft after they return to dialysis. This survey demonstrates heterogeneity in the care of patients with a failing allograft and the need for more evidence to guide improvements in clinical practice related to transition of care. 相似文献
5.
6.
7.
8.
9.
François Lüthi Miklos Pless Serge Leyvraz Beat Biedermann Emilie Müller Richard Hermann Christian Monnerat 《Supportive care in cancer》2010,18(12):1515-1520
Introduction
Anaemia during chemotherapy is often left untreated. Erythropoiesis-stimulating agents are frequently used to treat overt anaemia. Their prophylactic use, however, remains controversial and raises concerns about cost-effectiveness. Therefore, we assessed the efficacy of a dose-reduction schedule in anaemia prophylaxis. 相似文献10.
A novel rapid single nucleotide polymorphism (SNP)-based method for assessment of hematopoietic chimerism after allogeneic stem cell transplantation 总被引:5,自引:2,他引:5
下载免费PDF全文
![点击此处可从《Blood》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Hochberg EP Miklos DB Neuberg D Eichner DA McLaughlin SF Mattes-Ritz A Alyea EP Antin JH Soiffer RJ Ritz J 《Blood》2003,101(1):363-369
A major end point of nonmyeloablative hematopoietic stem cell transplantation is the attainment of either mixed chimerism or full donor hematopoiesis. Because the majority of human genetic disparity is generated by single nucleotide polymorphisms (SNPs), direct measurement of SNPs should provide a robust tool for the detection and quantitation of chimerism. Using pyrosequencing, a rapid quantitative sequencing technology, we developed a SNP-based assay for hematopoietic chimerism. Based on 14 SNPs with high allele frequencies, we were able to identify at least 1 informative SNP locus in 55 patients with HLA-identical donors. The median number of informative SNPs in related pairs was 5 and in unrelated pairs was 8 (P <.0001). Assessment of hematopoietic chimerism in posttransplantation DNA was shown to be quantitative, accurate, and highly reproducible. The presence of 5% donor cells was reliably detected in replicate assays. Compared with current measures of engraftment based on identification of short tandem repeats (STRs), variable number of tandem repeats (VNTRs), or microsatellite polymorphisms, this SNP-based method provides a more rapid and quantitative assessment of chimerism. A large panel of SNPs enhances the ability to identify an informative marker in almost all patient/donor pairs and also facilitates the simultaneous use of multiple markers to improve the statistical validity of chimerism measurements. The inclusion of SNPs that encode minor histocompatibility antigens or other genetic polymorphisms that may influence graft-versus-host disease or other transplantation outcomes can provide additional clinically relevant data. SNP-based assessment of chimerism is a promising technique that will assist in the analysis of outcomes following transplantation. 相似文献