全文获取类型
收费全文 | 101篇 |
免费 | 9篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 2篇 |
妇产科学 | 1篇 |
基础医学 | 12篇 |
口腔科学 | 5篇 |
临床医学 | 16篇 |
内科学 | 21篇 |
神经病学 | 10篇 |
特种医学 | 2篇 |
外科学 | 7篇 |
综合类 | 1篇 |
预防医学 | 9篇 |
眼科学 | 4篇 |
药学 | 12篇 |
肿瘤学 | 11篇 |
出版年
2023年 | 1篇 |
2022年 | 6篇 |
2021年 | 13篇 |
2020年 | 16篇 |
2019年 | 7篇 |
2018年 | 12篇 |
2017年 | 7篇 |
2016年 | 4篇 |
2015年 | 4篇 |
2014年 | 8篇 |
2013年 | 8篇 |
2012年 | 10篇 |
2011年 | 6篇 |
2010年 | 4篇 |
2009年 | 1篇 |
2008年 | 1篇 |
2007年 | 1篇 |
2006年 | 2篇 |
2005年 | 1篇 |
2003年 | 2篇 |
排序方式: 共有114条查询结果,搜索用时 15 毫秒
1.
Habib Sadeghirad Tayyeb Bahrami Sepideh M. Layeghi Hassan Yousefi Meysam Rezaei Seyed R. Hosseini-Fard Payar Radfar Majid E. Warkiani Ken O'Byrne Arutha Kulasinghe 《Immunology》2023,168(2):256-272
Non-small cell lung cancer (NSCLC) is one of the most common types of cancer in the world and has a 5-year survival rate of ~20%. Immunotherapies have shown promising results leading to durable responses, however, they are only effective for a subset of patients. To determine the best therapeutic approach, a thorough and in-depth profiling of the tumour microenvironment (TME) is required. The TME is a complex network of cell types that form an interconnected network, promoting tumour cell initiation, growth and dissemination. The stroma, immune cells and endothelial cells that comprise the TME generate a plethora of cytotoxic or cytoprotective signalling pathways. In this review, we discuss immunotherapeutic targets in NSCLC tumours and how the TME may influence patients' response to immunotherapy. 相似文献
2.
Mohammad Ali Zolfigol Mahya Kiafar Meysam Yarie Avat Taherpour Mahdi Saeidi-Rad 《RSC advances》2022,12(42):27114
Retraction of ‘Experimental and theoretical studies of the nanostructured {Fe3O4@SiO2@(CH2)3Im}C(CN)3 catalyst for 2-amino-3-cyanopyridine preparation via an anomeric based oxidation’ by Mohammad Ali Zolfigol et al., RSC Adv., 2016, 6, 50100–50111, https://doi.org/10.1039/C6RA12299J.The Royal Society of Chemistry hereby wholly retracts this RSC Advances article as the synthesis of {Fe3O4@SiO2@(CH2)3Im}C(CN)3 reported in the article, whereby tricyanomethane is used as a starting material, is not reproducible. The authors stated that they did not report the synthesis of tricyanomethane in the published paper as they purchased this compound from a commercial center and used it in the synthesis of ionic liquids, molten salts and various kinds of catalysts. The authors thought the reaction between tricyanomethane and organic bases is a simple acid–base reaction, therefore they did not cite the previously reported literature and its related history for the preparation of tricyanomethane. However, according to papers by Banert et al.,1,2 and based on their obtained analysis of the chemical sold to them as tricyanomethane, it became clear to the authors that this purchased compound was not tricyanomethane as there were differences in the 1H NMR and 13C NMR chemical shift between the purchased compound and the reports of Banert et al.1 According to these documents, the authors believe that the compound sold to them as tricyanomethane was fake. While the authors have now re-prepared {Fe3O4@SiO2@(CH2)3Im}C(CN)3, by synthesising potassium tricyanomethanide as a starting material for the synthesis,3–5 the synthesis reported in this article is not accurate. Therefore, this article is being retracted to avoid misleading readers and to protect the accuracy and integrity of the scientific record.Mohammad Ali Zolfigol and Meysam Yarie oppose the retraction. Mahya Kiafar, Avat (Arman) Taherpour and Mahdi Saeidi-Rad were contacted but did not respond.Signed: Laura Fisher, Executive Editor, RSC AdvancesDate: 17th August 2022 相似文献
3.
4.
Mohamadnejad M Pourshams A Malekzadeh R Mohamadkhani A Rajabiani A Asgari AA Alimohamadi SM Razjooyan H Mamar-Abadi M 《World journal of gastroenterology : WJG》2003,9(10):2322-2324
AIM: The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS: A total of 1,939 blood donors were included. ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels were computed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels. RESULTS: Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L, and for non-overweight men was 40 U/L. CONCLUSION: Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately. 相似文献
5.
Mehdi Mohamadnejad Akram Pourshams Reza Malekzadeh Ashraf Mohamadkhani Afsaneh Rajabiani Ali Ali Asgari Seyed Meysam Alimohamadi Hadi Razjooyan Mamar-Abadi 《World journal of gastroenterology : WJG》2003,9(10)
AIM:The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors.METHODS: A total of 1 939 blood donors were included.ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels were computed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels.RESULTS: Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L,and for non-overweight men was 40 U/L.CONCLUSION: Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately. 相似文献
6.
Hamid Badrian Amin Davoudi Meysam Molazem Mohammad Hossein Zare 《Journal of Indian Prosthodontic Society》2015,15(3):263-267
Background:
Dentistry equipment are exposed to different types of pathogenic microorganisms. The aim of this study was to investigate the effect of spraying three different types of disinfectants on condensational silicones after 5 and 10 min.Materials and Methods:
Totally, 66 circular samples of condensational silicone impression materials of 1 cm diameter and 2 mm thickness were contaminated by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans fungus. Except for control samples, all of them were disinfected with sodium hypochlorite (NaOCl) 0.525%, Deconex and Epimax by spraying method. Afterward, they kept in plastic bags with humid rolled cotton for 5 and 10 min. In order to isolate microbiotas, the samples were immersed in 2% trypsin for 1 h and diluted with normal saline in a portion of 1, 1/2, and 1/4. The trypsin suspensions were transferred to culture plates for incubation and colony-forming unit assay. The data were analyzed by Mann–Whitney test and SPSS software version 16 at a significant level of 0.05.Results:
There was a meaningful difference between disinfection effects of Epimax-Deconex for all mentioned microorganisms after 5 min (P = 0.034), and between disinfection effects of NaOCl 0.525%-Epimax for S. aureus (P = 0.043) and P. aeruginosa (P = 0.046) after 5 min. Furthermore, there was a meaningful difference between disinfection effects of Epimax-Deconex (P = 0.034) and NaOCl 0.525%-Epimax (P = 0.034) for P. aeruginosa after 10 min.Conclusion:
Condensational silicone can be effectively disinfected by spraying tested three disinfecting agents. More specifically, Deconex showed the best results compared to the other agents.Key Words: Condensational silicone, disinfection, impression materials, spray 相似文献7.
Arash Salmaninejad Arezoo Gowhari Seyedmojtaba Hosseini Saeed Aslani Meysam Yousefi Tayyeb Bahrami 《Journal of immunotoxicology》2017,14(1):137-151
Behçet’s disease (BD) is a chronic autoimmune condition primarily prevalent in populations along the Mediterranean Sea. The exact etiology of BD has not been fully explained yet, but the disease occurrence is associated with a genetic factor, human leukocyte antigen (HLA)-B51 antigen. Among the various immunodysfunctions that are found in BD, patients are increased neutrophil motility and superoxide production, as well as elevated production of tumor necrosis factor (TNF)-α and decreased production of interleukin (IL)-10. Elevated levels of inflammatory cytokines like IL-1 and IL-17 in BD have been found associated with aberrant expression of microRNA. Gene polymorphisms in BD patients have been observed in molecules involved in responses to pathogens that can ultimately modulate the host antimicrobial response. Moreover, several single nucleotide polymorphisms (SNPs) have been reported in genes encoding chemokines and adhesion molecules; many of these changes manifest as increases in vascular inflammation and vascular damage. Lastly, genetic and epigenetic changes have been suggested as involved in the pathogenesis of BD. Modifications in DNA methylation have been found in BD patient monocytes and lymphocytes, leading to adverse function of these cells. This review presents a comprehensive compilation of the literature with regard to the immunodysfunction underlying BD, as well as of the genetics, newly described clinical specifications and novel treatment strategies using immunomodulants based on the current understanding of BD. 相似文献
8.
Modified cold-induced aggregation microextraction (M-CIAME) is a fast and simple method for extraction and preconcentration of metal ions from samples with high salt content. Furthermore, this technique is much safer in comparison with the organic solvent extraction. The extraction of palladium (Pd) was performed in the presence of Michler thioketone (TMK) as the complexing agent. In this method, sodium hexafluorophosphate (NaPF6) was added to the sample solution containing small amounts of 1-hexyl-3-methylimidazolium tetrafluoroborate [Hmim][BF4]. Afterwards, the solution was placed in the ice bath and a cloudy solution was formed. After centrifuging, the extraction phase was settled. Under the optimum conditions, the limit of detection (LOD) was 0.2 ng mL−1. The relative standard deviation (RSD) was 1.7% for 40 ng mL−1 of palladium (n = 5). 相似文献
9.
Raeisossadati R Farshchian M Ganji A Tavassoli A Velayati A Dadkhah E Chavoshi S Mehrabi Bahar M Memar B Rajabi Mashhadi MT Naseh H Forghanifard MM Moghbeli M Moaven O Abbaszadegan MR 《International journal of colorectal disease》2011,26(10):1265-1270
Background
Colorectal cancer (CRC) remains the third most common cancer in the world. Approximately in 50 percent of patients, metastatic disease is a major cause of death. Therefore, early diagnosis of CRC is crucial for a successful outcome. For the detection of circulating cancer cells, this study applied a sensitive method that employed specific tumor markers for early detection.Methods
A total of 80 blood samples from 40 CRC patients and 40 age-matched healthy controls were collected for the study. The circulating mRNA levels of two CRC tumor markers, tumor endothelial marker 8 (TEM-8) and carcinoembryogenic antigen (CEA) were evaluated using an absolute quantitative real-time PCR assay in a Stratagene Mx-3000P real-time PCR system. GAPDH was used as the endogenous control.Results
TEM-8 and CEA were primarily detected more in the CRC patients rather than in the controls: 22/40 vs 9/40, p=0.009 and 30/40 vs 11/40, p=0.00054, respectively. In the CRC patients, the mRNA level of these markers was significantly higher in comparison to the normal controls (p=0.018 and 0.01). The overall sensitivity of this panel was 65% with a specificity of 75%. Statistical analysis for demographic variants did not reach significant values.Conclusions
TEM-8 and CEA markers were detected more frequently and in significantly higher levels in the blood samples of patients compared with samples from age-matched healthy controls. The copy number of CEA and TEM-8 mRNA, as detected by a real-time quantitative PCR, appears to be a promising marker for evaluating the risk of tumor spread. 相似文献10.