全文获取类型
收费全文 | 2774篇 |
免费 | 297篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 82篇 |
妇产科学 | 94篇 |
基础医学 | 400篇 |
口腔科学 | 53篇 |
临床医学 | 359篇 |
内科学 | 517篇 |
皮肤病学 | 78篇 |
神经病学 | 170篇 |
特种医学 | 178篇 |
外国民族医学 | 1篇 |
外科学 | 489篇 |
综合类 | 88篇 |
一般理论 | 2篇 |
预防医学 | 179篇 |
眼科学 | 22篇 |
药学 | 229篇 |
1篇 | |
中国医学 | 3篇 |
肿瘤学 | 144篇 |
出版年
2022年 | 20篇 |
2021年 | 37篇 |
2019年 | 30篇 |
2018年 | 40篇 |
2017年 | 32篇 |
2016年 | 34篇 |
2015年 | 43篇 |
2014年 | 81篇 |
2013年 | 109篇 |
2012年 | 109篇 |
2011年 | 86篇 |
2010年 | 70篇 |
2009年 | 75篇 |
2008年 | 94篇 |
2007年 | 144篇 |
2006年 | 102篇 |
2005年 | 103篇 |
2004年 | 92篇 |
2003年 | 78篇 |
2002年 | 82篇 |
2001年 | 88篇 |
2000年 | 75篇 |
1999年 | 82篇 |
1998年 | 70篇 |
1997年 | 65篇 |
1996年 | 67篇 |
1995年 | 66篇 |
1994年 | 51篇 |
1993年 | 49篇 |
1992年 | 83篇 |
1991年 | 78篇 |
1990年 | 59篇 |
1989年 | 84篇 |
1988年 | 73篇 |
1987年 | 60篇 |
1986年 | 49篇 |
1985年 | 60篇 |
1984年 | 56篇 |
1983年 | 43篇 |
1982年 | 35篇 |
1981年 | 26篇 |
1980年 | 32篇 |
1979年 | 29篇 |
1978年 | 21篇 |
1977年 | 30篇 |
1976年 | 15篇 |
1974年 | 21篇 |
1973年 | 21篇 |
1968年 | 14篇 |
1966年 | 17篇 |
排序方式: 共有3118条查询结果,搜索用时 15 毫秒
1.
2.
Guerard W. Byrne Johannes M. Schirmer David N. Fass Sumeet S. Teotia Walter K. Kremers Hui Xu Bashoo Naziruddin Henry D. Tazelaar John S. Logan Christopher G. A. McGregor 《American journal of transplantation》2005,5(5):1011-1020
Microvascular thrombosis is a prominent feature in cardiac delayed xenograft rejection (DXR). We investigated the impact of warfarin or low-molecular-weight heparin (LMWH) anti-coagulation on xenograft function using a heterotopic pig-to-primate model. Donor hearts were from CD46 transgenic pigs and baboon immunosuppression included tacrolimus, sirolimus, anti-CD20 and TPC, an alpha-galactosyl-polyethylene glycol conjugate. Three groups of animals were studied. Group 1 (n = 9) was treated with warfarin, Group 2 (n = 13) with LMWH and Group 3, received no anti-coagulant drugs. The median duration of xenograft function was 20 days (range 3-62 days), 18 days (range 5-109 days) and 15 days (range 4-53 days) in Groups 1 to 3 respectively. Anti-coagulation achieved the targeted international normalized prothrombin ratio (INR) and anti-factor Xa levels consistent with effective in vivo therapy yet, no significant impact on median xenograft function was observed. At rejection, a similar histology of thrombosis and ischemia was apparent in each group and the levels of fibrin deposition and platelet thrombi in rejected tissue was the same. Anti-coagulation with warfarin or LMWH did not have a significant impact on the onset of DXR and microvascular thrombosis. However, a role for specific anti-coagulant strategies to achieve long-term xenograft function cannot be excluded. 相似文献
3.
4.
5.
Carel Bron Michel Wensing Jo LM Franssen Rob AB Oostendorp 《BMC musculoskeletal disorders》2007,8(1):107
Background
Shoulder disorders are a common health problem in western societies. Several treatment protocols have been developed for the clinical management of persons with shoulder pain. However available evidence does not support any protocol as being superior over others. Systematic reviews provide some evidence that certain physical therapy interventions (i.e. supervised exercises and mobilisation) are effective in particular shoulder disorders (i.e. rotator cuff disorders, mixed shoulder disorders and adhesive capsulitis), but there is an ongoing need for high quality trials of physical therapy interventions. Usually, physical therapy consists of active exercises intended to strengthen the shoulder muscles as stabilizers of the glenohumeral joint or perform mobilisations to improve restricted mobility of the glenohumeral or adjacent joints (shoulder girdle). It is generally accepted that a-traumatic shoulder problems are the result of impingement of the subacromial structures, such as the bursa or rotator cuff tendons. Myofascial trigger points (MTrPs) in shoulder muscles may also lead to a complex of symptoms that are often seen in patients diagnosed with subacromial impingement or rotator cuff tendinopathy. Little is known about the treatment of MTrPs in patients with shoulder disorders. 相似文献6.
7.
The aim of this article is to provide clinicians and researchers a comprehensive overview of the development and functions of gesture in childhood and in select populations with developmental language impairments. Of significance is the growing body of evidence that gesture enhances, not hinders, language development. In both normal and impaired populations, gesture and language development parallel each other and share underlying symbolic abilities. Gesture serves several functions, including those of communication, compensation, and transition to spoken language. In clinical practice, gesture may play a valuable role in diagnosis, prognosis, goal selection, and intervention for children with language impairments. Where available, supporting evidence is presented. Needs for additional research on gesture are also highlighted. 相似文献
8.
9.
Immunohistochemical demonstration of human papilloma virus antigen in human colon neoplasms 总被引:6,自引:0,他引:6
The presence of human papilloma virus (HPV) has recently been demonstrated in colon tumors, but the incidence of HPV infection in normal colon mucosa or in benign or malignant neoplasms of the mucosa is unknown. We studied both neoplastic and normal human colon tissue for the presence of HPV antigen using immunohistochemical techniques. Ninety colon specimens were studied. Three consecutive series of normal colon mucosa (N = 30), single benign tubulovillous adenomas (N = 30), and invasive carcinomas (N = 30) were selected and confirmed histologically. Formalin-fixed paraffin-embedded samples of each tissue were prepared using immunohistochemical techniques and resultant slides were read blindly and graded simply as positive or negative for HPV antigen. The presence of HPV antigen varied dramatically between groups, with 97% of the invasive carcinomas, 60% of the benign tubulovillous adenomas, and 23% of the normal mucosa positive for HPV antigen. Groups were statistically significant using chi 2 analysis (P less than 0.001). We conclude that an association exists between the human colon neoplasia and the presence of HPV antigen. This may suggest an etiologic role of the virus in colon cancer. 相似文献
10.