全文获取类型
收费全文 | 695篇 |
免费 | 50篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 47篇 |
妇产科学 | 21篇 |
基础医学 | 69篇 |
口腔科学 | 20篇 |
临床医学 | 58篇 |
内科学 | 112篇 |
皮肤病学 | 8篇 |
神经病学 | 32篇 |
特种医学 | 108篇 |
外科学 | 36篇 |
综合类 | 10篇 |
一般理论 | 1篇 |
预防医学 | 66篇 |
眼科学 | 13篇 |
药学 | 21篇 |
肿瘤学 | 135篇 |
出版年
2022年 | 3篇 |
2021年 | 6篇 |
2020年 | 13篇 |
2019年 | 11篇 |
2018年 | 12篇 |
2017年 | 8篇 |
2016年 | 10篇 |
2015年 | 18篇 |
2014年 | 18篇 |
2013年 | 24篇 |
2012年 | 32篇 |
2011年 | 22篇 |
2010年 | 22篇 |
2009年 | 22篇 |
2008年 | 31篇 |
2007年 | 29篇 |
2006年 | 24篇 |
2005年 | 21篇 |
2004年 | 23篇 |
2003年 | 19篇 |
2002年 | 19篇 |
2001年 | 16篇 |
2000年 | 32篇 |
1999年 | 8篇 |
1998年 | 27篇 |
1997年 | 42篇 |
1996年 | 29篇 |
1995年 | 21篇 |
1994年 | 16篇 |
1993年 | 8篇 |
1992年 | 9篇 |
1991年 | 9篇 |
1990年 | 12篇 |
1989年 | 18篇 |
1988年 | 14篇 |
1987年 | 7篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1984年 | 8篇 |
1983年 | 14篇 |
1982年 | 6篇 |
1981年 | 8篇 |
1980年 | 8篇 |
1979年 | 4篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1976年 | 7篇 |
1975年 | 5篇 |
1973年 | 2篇 |
1972年 | 3篇 |
排序方式: 共有758条查询结果,搜索用时 15 毫秒
1.
Toward a VA women’s health research agenda: Setting evidence-based priorities to improve the health and health care of women veterans
下载免费PDF全文
![点击此处可从《Journal of general internal medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Elizabeth M. Yano Lori A. Bastian Susan M. Frayne Alexandra L. Howell Linda R. Lipson Geraldine McGlynn Paula P. Schnurr Margaret R. Seaver Ann M. Spungen Stephan D. Fihn 《Journal of general internal medicine》2006,21(3):S93-S101
The expansion of women in the military is reshaping the veteran population, with women now constituting the fastest growing segment of eligible VA health care users. In recognition of the changing demographics and special health care needs of women, the VA Office of Research & Development recently sponsored the first national VA Women’s Health Research Agenda-setting conference to map research priorities to the needs of women veterans and position VA as a national leader in Women’s Health Research. This paper summarizes the process and outcomes of this effort, outlining VA’s research priorities for biomedical, clinical, rehabilitation, and health services research. 相似文献
2.
Vincent B. Killeen Harry Reich Fran McGlynn Lawrence A. Virgilio Michael A. Krawitz Lisa Sekel 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》1997,1(3):267-268
The third reported case of pelvic gliomatosis found within foci of endometriosis is documented 16 years after the removal of a benign cystic teratoma. Grossly at laparoscopy the lesions appear as typical deep fibrotic endometriotic implants. 相似文献
3.
E Buchdunger U Trinks H Mett U Regenass M Müller T Meyer E McGlynn L A Pinna P Traxler N B Lydon 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(6):2334-2338
Deregulated signal transduction via the epidermal growth factor receptor (EGF-R) family of protein-tyrosine kinase growth factor receptors is associated with proliferative diseases. We describe a class of compounds (4,5-dianilinophthalimides) that inhibit the EGF-R protein-tyrosine kinase in vitro with high selectivity. In cells, 4,5-dianilinophthalmide selectively inhibited both ligand-induced EGF-R and p185c-erbB2 autophosphorylation and c-fos mRNA induction. Antitumor activity could be demonstrated in vivo against xenografts of the A431 and SK-OV-3 tumors, which overexpress the EGF-R and p185c-erbB2, respectively. In contrast, a platelet-derived growth factor-driven tumor was not inhibited by 4,5-dianilinophthalimide, which is compatible with its cellular selectivity and hypothesized mechanism of action. No overt cumulative toxicity was observed during treatment even though high efficacy was observed, indicating a good therapeutic window. 4,5-Dianilinophthalimides may offer therapeutic agents for the treatment of hyperproliferative diseases that overexpress EGF-R family protein-tyrosine kinases or their ligands. 相似文献
4.
5.
6.
D J Delprato F D McGlynn 《Journal of behavior therapy and experimental psychiatry》1988,19(3):199-205
Basic and clinical behavioral research reveals that actions of the organism frequently are organized to form concurrent and sequential response patterns. The former are nonrandom interrelationships among two or more responses that are measured over the same time period. Sequential response patterns are nonrandom relationships between responses when measured over time. This paper addresses some implications of response patterns for assessment and intervention in behavior therapy. 相似文献
7.
8.
A comparison of Skirrow's, Butzler's, Blaser's, Campy-BAP and Preston media for Campylobacter spp was made using human, animal and environmental specimens. Butzler's medium gave the lowest isolation rate and Preston medium, which was the most selective, the highest isolation rate. Enrichment culture using Preston enrichment broth gave a higher isolation rate than direct plating onto Preston medium. 相似文献
9.
Pfeifer JD Ashley Hill D Ramos CV Wippold FJ II Dehner LP 《Archives of pathology & laboratory medicine》2000,124(6):898-901
A 77-year-old woman with neurofibromatosis type 1 presented with ill-fitting dentures due to intraoral extension of a right temporal fossa mass. Computed tomographic scanning demonstrated that the masticator space mass bowed the zygomatic arch and remodeled the lateral orbit and maxillary sinus walls, findings that were consistent with the clinical diagnosis of a neurofibroma with possible malignant transformation. However, light microscopic, immunohistochemical, and ultrastructural examination of tissue from an incisional biopsy specimen were diagnostic of meningioma. This case illustrates that the clinicopathologic differential diagnosis of an enlarging mass in patient with neurofibromatosis should include sporadic, unrelated neoplasms as well as tumors known to be associated with the syndrome. 相似文献
10.
Frataxin is reduced in Friedreich ataxia patients and is associated with mitochondrial membranes 总被引:17,自引:8,他引:17
Campuzano V; Montermini L; Lutz Y; Cova L; Hindelang C; Jiralerspong S; Trottier Y; Kish SJ; Faucheux B; Trouillas P; Authier FJ; Durr A; Mandel JL; Vescovi A; Pandolfo M; Koenig M 《Human molecular genetics》1997,6(11):1771-1780
Friedreich ataxia is a progressive neurodegenerative disorder caused by
loss of function mutations in the frataxin gene. In order to unravel
frataxin function we developed monoclonal antibodies raised against
different regions of the protein. These antibodies detect a processed 18
kDa protein in various human and mouse tissues and cell lines that is
severely reduced in Friedreich ataxia patients. By immunocytofluorescence
and immunocytoelectron microscopy we show that frataxin is located in
mitochondria, associated with the mitochondrial membranes and crests.
Analysis of cellular localization of various truncated forms of frataxin
expressed in cultured cells and evidence of removal of an N-terminal
epitope during protein maturation demonstrated that the mitochondrial
targetting sequence is encoded by the first 20 amino acids. Given the
shared clinical features between Friedreich ataxia, vitamin E deficiency
and some mitochondriopathies, our data suggest that a reduction in frataxin
results in oxidative damage.
相似文献