全文获取类型
收费全文 | 8768篇 |
免费 | 867篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 291篇 |
妇产科学 | 155篇 |
基础医学 | 906篇 |
口腔科学 | 139篇 |
临床医学 | 1176篇 |
内科学 | 2038篇 |
皮肤病学 | 130篇 |
神经病学 | 756篇 |
特种医学 | 620篇 |
外科学 | 1464篇 |
综合类 | 266篇 |
一般理论 | 6篇 |
预防医学 | 768篇 |
眼科学 | 74篇 |
药学 | 432篇 |
中国医学 | 7篇 |
肿瘤学 | 429篇 |
出版年
2023年 | 77篇 |
2022年 | 64篇 |
2021年 | 126篇 |
2020年 | 160篇 |
2019年 | 122篇 |
2018年 | 222篇 |
2017年 | 160篇 |
2016年 | 179篇 |
2015年 | 165篇 |
2014年 | 221篇 |
2013年 | 377篇 |
2012年 | 386篇 |
2011年 | 413篇 |
2010年 | 287篇 |
2009年 | 263篇 |
2008年 | 337篇 |
2007年 | 368篇 |
2006年 | 384篇 |
2005年 | 301篇 |
2004年 | 335篇 |
2003年 | 293篇 |
2002年 | 292篇 |
2001年 | 285篇 |
2000年 | 263篇 |
1999年 | 252篇 |
1998年 | 172篇 |
1997年 | 177篇 |
1996年 | 158篇 |
1995年 | 120篇 |
1994年 | 112篇 |
1993年 | 116篇 |
1992年 | 203篇 |
1991年 | 200篇 |
1990年 | 189篇 |
1989年 | 211篇 |
1988年 | 155篇 |
1987年 | 154篇 |
1986年 | 134篇 |
1985年 | 146篇 |
1984年 | 112篇 |
1983年 | 92篇 |
1982年 | 67篇 |
1981年 | 60篇 |
1980年 | 56篇 |
1979年 | 76篇 |
1978年 | 70篇 |
1977年 | 51篇 |
1976年 | 46篇 |
1974年 | 47篇 |
1973年 | 44篇 |
排序方式: 共有9685条查询结果,搜索用时 15 毫秒
1.
2.
Martina A. Steurer Jean Costello Rebecca J. Baer Scott P. Oltman Sky K. Feuer Tania Pacheco-Werner Elizabeth Rogers Marta M. Jankowska Jessica Block Molly McCarthy Matthew S. Pantell Christina Chambers Kelli K. Ryckman Laura L. Jelliffe-Pawlowski 《Paediatric and perinatal epidemiology》2020,34(2):130-138
3.
Béla Nagy Zsolt Bene Zsolt Fejes Sonya L. Heltshe David Reid Nicola J. Ronan Yvonne McCarthy Daniel Smith Attila Nagy Elizabeth Joseloff György Balla János Kappelmayer Milan Macek Scott C. Bell Barry J. Plant Margarida D. Amaral István Balogh 《Journal of cystic fibrosis》2019,18(2):271-277
Background
We have recently shown that human epididymis protein 4 (HE4) levels correlate with the severity of cystic fibrosis (CF) lung disease. However, there are no data on how HE4 levels alter in patients receiving CFTR modulating therapy.Methods
In this retrospective clinical study, 3 independent CF patient cohorts (US-American: 29, Australian: 12 and Irish: 19 cases) were enrolled carrying at least one Class III CFTR CF-causing mutation (p.Gly551Asp) and being treated with CFTR potentiator ivacaftor. Plasma HE4 was measured by immunoassay before treatment (baseline) and 1–6?months after commencement of ivacaftor, and were correlated with FEV1 (% predicted), sweat chloride, C-reactive protein (CRP) and body mass index (BMI).Results
After 1?month of therapy, HE4 levels were significantly lower than at baseline and remained decreased up to 6?months. A significant inverse correlation between absolute and delta values of HE4 and FEV1 (r?=??0.5376; P?<?.001 and r?=??0.3285; P?<?.001), was retrospectively observed in pooled groups, including an independent association of HE4 with FEV1 by multiple regression analysis (β?=??0.57, P?=?.019). Substantial area under the receiver operating characteristic curve (ROC-AUC) value was determined for HE4 when 7% mean change of FEV1 (0.722 [95% CI 0.581–0.863]; P?=?.029) were used as classifier, especially in the first 2?months of treatment (0.806 [95% CI 0.665–0.947]; P?<?.001).Conclusions
This study shows that plasma HE4 levels inversely correlate with lung function improvement in CF patients receiving ivacaftor. Overall, this potential biomarker may be of value for routine clinical and laboratory follow-up of CFTR modulating therapy. 相似文献4.
5.
6.
7.
8.
9.
R M Sandford M J Bown R D Sayers J N London A R Naylor M J McCarthy 《European journal of vascular and endovascular surgery》2007,34(1):29-34
OBJECTIVES: Angioplasty is often used in the management of lower limb ischaemia and can reduce the need for infrainguinal bypass in some patients. There is an associated failure rate with this technique and bypass surgery is often used in this situation as a secondary limb salvage procedure. We aimed to evaluate the outcome of infrainguinal bypass grafting following failed attempt at angioplasty. METHODS: All cases of infrainguinal bypass at a single centre over a seven year period were identified and notes reviewed. Cases were divided into four groups according to their indication for surgery; acute ischaemia, chronic critical ischaemia, failed angioplasty and an 'other' group including aneurysmal disease and claudicants. The failed angioplasty group was compared with the other three groups. Survival analysis was performed using Kaplan Meier curves and groups compared in terms of long term patency and survival. RESULTS: Primary patency was 61.2% in the failed angioplasty group at 12 months compared with 60.6% in the other groups (P=1.11). There was also no significant difference in primary patency at 60 months (50% vs 40.6%, P=0.26). Survival at 12 months was also comparable between the groups (failed angioplasty group 74.2% compared with 77.3% in the other groups, P=0.662) as was 60 months survival (33.3% and 35.4% respectively, P=0.166). DISCUSSION: In this study, outcome of infrainguinal bypass following failed angioplasty was comparable to outcome of surgery performed for another indication. This paper supports the use of distal bypass surgery for limb salvage in cases where minimal access techniques have failed. 相似文献
10.
Very little information is available concerning the pharmacology of type 2 astroglia. During the past decade it has become apparent that two distinct lineages of astroglial cells can be defined in vitro. These two lineages are commonly referred to as type 1 and type 2 and are distinguished from each other on the basis of their morphological features and antigenic phenotypes. In contrast to type 1 astroglia, very little is known about the pharmacology of type 2 astroglia. The lack of information concerning the responsiveness of these cells stems primarily from difficulties encountered in isolating large numbers of type 2 astroglia free of other cell types. In the present study video- and photometer-based imaging systems were used to monitor the influence of a series of neuroligands on the intracellular calcium levels of individual cerebral type 2 astroglia in order to assess their expression of calcium-mobilizing receptors. The responses of 85 immunocytochemically identified cerebral type 2 astroglia to bradykinin (BK), norepinephrine (NE), histamine (HIST), carbachol (CARB), 2-methyl-thio ATP (2MT-ATP), glutamate (GLUT), and serotonin (5-HT) were analyzed. Approximately 50% of cerebral type 2 astroglia responded to BK, NE, HIST, CARB, and 2MT-ATP whereas only 16% and 9% of the cells responded to GLUT and 5-HT, respectively. The number of neuroligands that increased calcium in individual cells ranged from 0 to 6. These responses are quite similar to those previously demonstrated in cultured cerebral type 1 astroglia. No pattern of receptor co-expression was observed for the different neuroligands tests.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献