神经生长因子对小鼠突触体内Ca^2＋水平的调节作用

观察了多次海马内微注射ＮＧＦ对小鼠突触体内游离钙水平的影响，并在离体情况下观察ＮＧＦ对ＥＧＴＡ和ＣａＣｌ２分别造成突触体内低钙和高钙状态的调节作用。结果如下：（１）在体实验表明，一定剂量的ＮＧＦ可显著降低老年小鼠海马突触体内游离钙水平（Ｐ＜００５）；（２）离体实验表明，当突触体游离钙水平降低时，适当剂量的ＮＧＦ具有升高游离钙水平的作用；而突触体内游离钙水平升高时，则ＮＧＦ有降低游离钙水平的作用。提示ＮＧＦ对游离钙水平的双向调节作用可能是ＮＧＦ改善老年性记忆衰退的作用机制。     

Management of the neuropathic bladder by clean intermittent catheterisation: 5 year outcomes

Based on a telephone interview and medical record review of the urological outcomes among 40 spinal cord injury patients with a neuropathic bladder at discharge who were an average of 60 months post-injury and who were all initially managed by chronic clean intermittent catheterisation (CCIC), the following conclusions were made: Over 80% of patients using CCIC at discharge continued to use it, suggesting low morbidity and high patient acceptance; Urological complications in patients using CCIC were more frequent in the lower urinary tract than in the upper urinary tract, were more frequent in men than women, and had a low morbidity; Urological complications and hospitalisations were more frequent among the 41% of patients using CCIC who had frequent SxUTIs; SxUTIs were common in patients using CCIC but rates may be comparable with other methods; Although 44% of CCIC patients were hospitalised at least once in 5 years for urological complications, this is comparable to reported multi-centre outcomes in the U.S.A. (Young, 1982).