全文获取类型
收费全文 | 1823篇 |
免费 | 138篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 52篇 |
妇产科学 | 45篇 |
基础医学 | 402篇 |
口腔科学 | 34篇 |
临床医学 | 169篇 |
内科学 | 305篇 |
皮肤病学 | 54篇 |
神经病学 | 156篇 |
特种医学 | 72篇 |
外科学 | 190篇 |
综合类 | 10篇 |
预防医学 | 166篇 |
眼科学 | 37篇 |
药学 | 182篇 |
中国医学 | 11篇 |
肿瘤学 | 53篇 |
出版年
2023年 | 17篇 |
2022年 | 21篇 |
2021年 | 52篇 |
2020年 | 33篇 |
2019年 | 46篇 |
2018年 | 96篇 |
2017年 | 61篇 |
2016年 | 106篇 |
2015年 | 82篇 |
2014年 | 115篇 |
2013年 | 198篇 |
2012年 | 96篇 |
2011年 | 76篇 |
2010年 | 119篇 |
2009年 | 49篇 |
2008年 | 44篇 |
2007年 | 42篇 |
2006年 | 62篇 |
2005年 | 20篇 |
2004年 | 19篇 |
2003年 | 18篇 |
2002年 | 23篇 |
2001年 | 28篇 |
2000年 | 34篇 |
1999年 | 23篇 |
1998年 | 30篇 |
1997年 | 24篇 |
1996年 | 20篇 |
1995年 | 17篇 |
1994年 | 16篇 |
1993年 | 16篇 |
1992年 | 14篇 |
1991年 | 11篇 |
1990年 | 15篇 |
1989年 | 19篇 |
1986年 | 12篇 |
1984年 | 12篇 |
1982年 | 10篇 |
1981年 | 13篇 |
1980年 | 9篇 |
1979年 | 15篇 |
1977年 | 13篇 |
1976年 | 12篇 |
1975年 | 12篇 |
1973年 | 9篇 |
1969年 | 8篇 |
1967年 | 13篇 |
1965年 | 11篇 |
1964年 | 8篇 |
1963年 | 9篇 |
排序方式: 共有1966条查询结果,搜索用时 0 毫秒
1.
ABSTRACTAlthough communication about sexuality is a significant pathway through which peers influence adolescent sexual development, little research has examined the role of peer networks in the use of sexualized media. We applied a social network approach to assess the role of close peers in adolescent pornography use and sexting in a sample of Croatian high school students. Sexual conversation networks’ characteristics did not correlate with pornography use. In contrast, sexting was associated with the proportion of same gender peers, the proportion of older peers and the proportion of sexually experienced peers in the network – pointing to the role of peer influence. Participants’ gender did not moderate these associations. Specific mechanisms underlying the observed associations and the role of peer selection remain important tasks for future research. 相似文献
2.
3.
4.
The temporal bones from fetuses with known autosomal trisomy syndromes were examined histopathologically after spontaneous or induced abortions. Fetal ages dated from the 17th to the 24th week of pregnancy. In all, 17 temporal bones from nine fetuses were studied and included seven cases of Down's syndrome and two of Edwards' syndrome. Temporal bones from fetuses with Down's syndrome had more abnormalities of the external and middle ears than of the inner ear. The bones from the fetuses with Edwards' syndrome showed abnormalities of the external or middle ear and retarded development of the inner ear (failed ossification of the otic capsule and unformed organ of Corti). 相似文献
5.
Mirna SuČIĆ Dubravka Boban Mirjana MarkoviĆ-glamoČak Mladen PetroveČki Matko MaruŠIĆ Boris Labar 《Medical oncology (Northwood, London, England)》1992,9(1):41-45
Cytochemical analysis of leukemic blasts from 46 patients with acute myeloblastic M2 leukemia (according to the FAB classification)
was performed before and after cytostatic therapy, and compared with findings obtained in 20 age- and sex-matched control
subjects. Cytochemical findings for myeloperoxidase (MPO), Sudan black B, acid phosphatase and alpha-naphthyl-acetate esterase
(ANAE) were related to the achievement of the first complete remission (CR),i.e. data were compared after the patients had been divided into CR and non-CR groups. The analysis clearly showed that a high
proportion of myeloperoxidase- and, to a lesser extent, Sudan black B-positive blasts before treatment may have constituted
a significantly unfavourable prognostic factor. 相似文献
6.
Eva Dragomirecka William R. Lenderking Lucie Motlova Eva Goppoldova Pavla Šelepova 《Quality of life research》2006,15(2):307-312
The Schwartz Outcomes Scale-10 (SOS-10) is a 10-item scale developed to measure the effectiveness of psychiatric treatments.
Using standard methodology, we translated the scale into Czech and examined the psychometric properties of the Czech version.
207 in-patients admitted to Prague Psychiatric Center were included in the study. All patients completed the SOS at admission
and discharge. The SOS-10 scale was also administered to 170 persons from the general population. Reliability, validity and
sensitivity to treatment change of the Czech SOS-10 were analyzed. The Cronbach’s α coefficient was 0.92. The item-total correlation coefficients varied from 0.56 to 0.82. The SOS-10 correlated well with condition-specific
measures including depression (BDI) and anxiety (BAI) and a global self-rated symptom severity scale (CGI). The SOS-10 also
had significant correlations with the Health, Basic needs, Relationship, and Leisure time domains of the Czech version of
the Subjective Quality of Life Analysis (SQUALA-CZ). The scale discriminated well between patients and controls, with patients
scoring significantly lower on all SOS items. The patient sample’s admission and discharge scores were significantly different,
indicating that the scale is sensitive to treatment changes. We concluded that the Czech SOS-10 is valid with reliability
and factor structure similar to the American language version. 相似文献
7.
Tomáš Šimůnek Martin Štěrba Olga Popelová Michaela Adamcová Radomír Hrdina Vladimír Geršl 《Pharmacological reports : PR》2009,61(1):154-171
The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of anthracycline antineoplastic antibiotics, which include doxorubicin (adriamycin), daunorubicin or epirubicin. Nevertheless, these compounds remain among the most widely used anticancer drugs. The molecular pathogenesis of anthracycline cardiotoxicity remains highly controversial, although the oxidative stress-based hypothesis involving intramyocardial production of reactive oxygen species (ROS) has gained the widest acceptance. Anthracyclines may promote the formation of ROS through redox cycling of their aglycones as well as their anthracycline-iron complexes. This proposed mechanism has become particularly popular in light of the high cardioprotective efficacy of dexrazoxane (ICRF-187). The mechanism of action of this drug has been attributed to its hydrolytic transformation into the iron-chelating metabolite ADR-925, which may act by displacing iron from anthracycline-iron complexes or by chelating free or loosely bound cellular iron, thus preventing site-specific iron-catalyzed ROS damage. However, during the last decade, calls for the critical reassessment of this “ROS and iron” hypothesis have emerged. Numerous antioxidants, although efficient in cellular or acute animal experiments, have failed to alleviate anthracycline cardiotoxicity in clinically relevant chronic animal models or clinical trials. In addition, studies with chelators that are stronger and more selective for iron than ADR-925 have also yielded negative or, at best, mixed outcomes. Hence, several lines of evidence suggest that mechanisms other than the traditionally emphasized “ROS and iron” hypothesis are involved in anthracycline-induced cardiotoxicity and that these alternative mechanisms may be better bases for designing approaches to achieve efficient and safe cardioprotection. 相似文献
8.
Ljiljana Ševaljević Sanja Marinković Desanka Bogojević Svetlana Matić Bogdan Bošković 《Archives of toxicology》1989,63(5):406-411
We have studied the effect of soman intoxication on serum acute phase reactants (APR) levels, and the relationship of the APR and corticosterone concentrations and the immunosuppressive activity of the serum. One day after the injection of 1.8 LD50 soman the concentrations of 2-macroglobulin (2-MG) and 1-acid glycoprotein (AGP) in the serum of antidote protected rats increased 4- and 7-fold, respectively, whereas those of hemopexin (Hx), haptoglobin (Hp) and cysteine protease inhibitor (CPI) were two to three times higher than in the controls. A similar magnitude of increase of serum acute phase reactants levels was observed when 0.3 LD50 soman was administered at 24-h intervals over the 5-day period. The relationship of changes in the APR concentration, corticosterone level and immunosuppressive activity of the serum was also comparable to that observed in the acute phase response to tissue injury. 相似文献
9.
10.
J. Škopková I. Albrecht J. H. Cort 《Pflügers Archiv : European journal of physiology》1973,343(2):123-132
Summary Rats anaesthetised with Inactin, body temp. maintained at 37°C, were infused with mannitol-saline until both urine flow rate and conductivity reached a balanced state. In separate experiments under analogous conditions cardiac output was measured by dye dilution and organ flow rates by86Rb distribution. Doses of oxytocin of 3 ng or less, injected at or just below the carotid bifurcation, caused a highly significant natriuresis with increased tubular rejection, but no measureable haemodynamic changes. The same oxytocin dose given into the internal or external carotid artery above the bifurcation caused neither haemodynamic changes nor natriuresis. Injection of vasopressin, angiotensin and -MSH at the sensitive site did not result in natriuresis in the same dosage range. Section of the sinus nerve significantly decreased the natriuretic response to oxytocin. It is suggested that the carotid body contains a specific oxytocin receptor capable of eliciting natriuresis in the rat. 相似文献