全文获取类型
收费全文 | 8395篇 |
免费 | 670篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 100篇 |
儿科学 | 357篇 |
妇产科学 | 221篇 |
基础医学 | 1154篇 |
口腔科学 | 177篇 |
临床医学 | 880篇 |
内科学 | 1820篇 |
皮肤病学 | 373篇 |
神经病学 | 613篇 |
特种医学 | 258篇 |
外科学 | 1275篇 |
综合类 | 56篇 |
一般理论 | 7篇 |
预防医学 | 614篇 |
眼科学 | 80篇 |
药学 | 573篇 |
中国医学 | 3篇 |
肿瘤学 | 522篇 |
出版年
2023年 | 74篇 |
2022年 | 67篇 |
2021年 | 157篇 |
2020年 | 171篇 |
2019年 | 220篇 |
2018年 | 267篇 |
2017年 | 239篇 |
2016年 | 247篇 |
2015年 | 224篇 |
2014年 | 326篇 |
2013年 | 569篇 |
2012年 | 517篇 |
2011年 | 558篇 |
2010年 | 318篇 |
2009年 | 294篇 |
2008年 | 432篇 |
2007年 | 359篇 |
2006年 | 381篇 |
2005年 | 366篇 |
2004年 | 309篇 |
2003年 | 320篇 |
2002年 | 285篇 |
2001年 | 125篇 |
2000年 | 104篇 |
1999年 | 125篇 |
1998年 | 101篇 |
1997年 | 80篇 |
1996年 | 78篇 |
1995年 | 88篇 |
1994年 | 62篇 |
1993年 | 59篇 |
1992年 | 109篇 |
1991年 | 91篇 |
1990年 | 78篇 |
1989年 | 60篇 |
1988年 | 66篇 |
1987年 | 71篇 |
1986年 | 72篇 |
1985年 | 58篇 |
1984年 | 64篇 |
1983年 | 56篇 |
1982年 | 48篇 |
1981年 | 57篇 |
1980年 | 50篇 |
1979年 | 42篇 |
1978年 | 36篇 |
1977年 | 36篇 |
1975年 | 37篇 |
1972年 | 43篇 |
1971年 | 33篇 |
排序方式: 共有9083条查询结果,搜索用时 15 毫秒
1.
Marike Gabrielson Mattias Hammarström Magnus Bäcklund Jenny Bergqvist Kristina Lång Ann H Rosendahl Signe Borgquist Roxanna Hellgren Kamila Czene Per Hall 《International journal of cancer. Journal international du cancer》2023,152(11):2362-2372
Tamoxifen prevents recurrence of breast cancer and is suggested for preventive risk-reducing therapy. Tamoxifen reduces mammographic density, a proxy for therapy response, but little is known about its effects in remodelling normal breast tissue. Our study, a substudy within the double-blinded dose-determination trial KARISMA, investigated tamoxifen-specific changes in breast tissue composition and histological markers in healthy women. We included 83 healthy women randomised to 6 months daily intake of 20, 10, 5, 2.5, 1 mg of tamoxifen or placebo. The groups were combined to “no dose” (0-1 mg), “low-dose” (2.5-5 mg) or “high-dose” (10-20 mg) of tamoxifen. Ultrasound-guided biopsies were collected before and after tamoxifen exposure. In each biopsy, epithelial, stromal and adipose tissues was quantified, and expression of epithelial and stromal Ki67, oestrogen receptor (ER) and progesterone receptor (PR) analysed. Mammographic density using STRATUS was measured at baseline and end-of-tamoxifen-exposure. We found that different doses of tamoxifen reduced mammographic density and glandular-epithelial area in premenopausal women and associated with reduced epithelium and increased adipose tissue. High-dose tamoxifen also decreased epithelial ER and PR expressions in premenopausal women. Premenopausal women with the greatest reduction in proliferation also had the greatest epithelial reduction. In postmenopausal women, high-dose tamoxifen decreased the epithelial area with no measurable density decrease. Tamoxifen at both low and high doses influences breast tissue composition and expression of histological markers in the normal breast. Our findings connect epithelial proliferation with tissue remodelling in premenopausal women and provide novel insights to understanding biological mechanisms of primary prevention with tamoxifen. 相似文献
2.
3.
4.
Familial risk and heritability of intellectual disability: a population-based cohort study in Sweden
5.
Femoral access‐related complications during percutaneous transcatheter aortic valve implantation comparing single versus double Prostar XL device closure
下载免费PDF全文
![点击此处可从《Catheterization and cardiovascular interventions》网站下载免费的PDF全文](/ch/ext_images/free.gif)
6.
7.
A role for decorin in cutaneous wound healing and angiogenesis 总被引:2,自引:0,他引:2
Hannu Järveläinen MD PhD ; Pauli Puolakkainen MD PhD ; Sari Pakkanen MSc ; Eric L. Brown PhD ; Magnus Höök PhD ; Renato V. Iozzo MD ; E.Helene Sage PhD ; Thomas N. Wight PhD 《Wound repair and regeneration》2006,14(4):443-452
Decorin is known to influence tissue tensile strength and cellular phenotype. Therefore, decorin is likely to have an impact on tissue repair, including cutaneous wound healing. In this study, cutaneous healing of both excisional and incisional full‐thickness dermal wounds was studied in decorin‐deficient (Dcn?/?) animals. A statistically significant delay in excisional wound healing in the Dcn?/? mice occurred at 4 and 10 days postwounding and, in incisional wounds at 4, 10, and 18 days when compared with wild‐type (Dcn?/?) controls. Fibrovascular invasion into polyvinylalcohol sponges was significantly increased by day 18 in Dcn?/? mice relative to Dcn+/+ mice. The 18‐day sponge implants in the Dcn?/? mice showed a marked accumulation of biglycan when compared with the corresponding implants in Dcn+/+ mice. Thus, regulated production of decorin may serve as an excellent therapeutic approach for modifying impaired wound healing and harmful foreign body reactions. 相似文献
8.
Urticaria is a common condition, seldom of allergic origin. It is however not always possible to find the provoking allergen. The aim of the present study was to analyze if there was a relationship between urticaria and sensitization to common airborne allergens. A representative sample of 402 12 to 13-yr-old children answered a questionnaire on allergic diseases, 397 were interviewed by the study nurse and 371 underwent skin prick tests to cat, dog, horse, birch, timothy-grass, house dust mites and Cladosporium mould. Specific IgE-antibodies were analyzed to birch pollen and cat dander. Urticaria was more common in sensitized children, but the relationship between urticaria and sensitization was only statistically significant for birch pollen sensitization (OR 1.99, 95% CL 1.04-3.83), when tested in a multiple logistic regression model with the specified allergens as independent variables. A similar pattern was seen for birch-specific IgE-antibody levels, which was higher in children reporting urticaria than in those without. IgE-levels to cat dander did not show such a difference. Urticaria was statistically significantly associated with sensitization to birch-pollen, but not to other common inhalant allergens. We propose that intake of birch-pollen cross-reactive food-stuffs may be a neglected cause of urticaria and relapsing urticaria, in birch-pollen sensitized subjects. 相似文献
9.
Anders Moller MD Ralph Hasserius PhD Inga Redlund-Johnell PhD Acke Ohlin PhD Magnus K. Karlsson PhD 《The spine journal》2007,7(6):701-707
BACKGROUND CONTEXT: Several studies report a favorable short-term outcome after nonoperatively treated two-column thoracic or lumbar burst fractures in patients without neurological deficits. Few reports have described the long-term clinical and radiological outcome after these fractures, and none have, to our knowledge, specifically evaluated the long-term outcome of the discs adjacent to the fractured vertebra, often damaged at injury and possibly at an increased risk of height reduction and degeneration with subsequent chronic back pain. PURPOSE: To evaluate the long-term clinical and radiological outcome after nonoperatively treated thoracic or lumbar burst fractures in adults, with special attention to posttraumatic radiological disc height reduction. STUDY DESIGN: Case series. PATIENT SAMPLE: Sixteen men with a mean age of 31 years (range, 19-44) and 11 women with a mean age of 40 years (range, 23-61) had sustained a thoracic or lumbar burst fracture during the years 1965 to 1973. Four had sustained a burst fracture Denis type A, 18 a Denis type B, 1 a Denis type C, and 4 a Denis type E. Seven of these patients had neurological deficits at injury, all retrospectively classified as Frankel D. OUTCOME MEASURES: The clinical outcome was evaluated subjectively with Oswestry score and questions regarding work capacity and objectively with the Frankel scale. The radiological outcome was evaluated with measurements of local kyphosis over the fractured segment, ratios of anterior and posterior vertebral body heights, adjacent disc heights, pedicle widths, sagittal width of the spinal canal, and lateral and anteroposterior displacement. METHODS: From the radiographical archives of an emergency hospital, all patients with a nonoperatively treated thoracic or lumbar burst fracture during the years 1965 to 1973 were registered. The fracture type, localization, primary treatment, and outcome were evaluated from the old radiographs, referrals, and reports. Twenty-seven individuals were clinically and radiologically evaluated a mean of 27 years (range, 23-41) after the injury. RESULTS: At follow-up, 21 former patients reported no or minimal back pain or disability (Oswestry Score mean 4; range, 0-16), whereas 6 former patients (of whom 3 were classified as Frankel D at baseline) reported moderate or severe disability (Oswestry Score mean 39; range, 26-54). Six former patients were classified as Frankel D, and the rest as Frankel E. Local kyphosis had increased by a mean of 3 degrees (p<.05), whereas the discs adjacent to the fractured vertebrae remained unchanged in height during the follow-up. CONCLUSIONS: Nonoperatively treated burst fractures of the thoracic or lumbar spine in adults with or without minor neurological deficits have a predominantly favorable long-term outcome, and there seems to be no increased risk for subsequent disc height reduction in the adjacent discs. 相似文献
10.