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1.
YOSHIKAZU YONEI YOSUKE YOSHIZAKI NOBUHIRO TSUKADA YASUTAKA INAGAKI KEI MIYAMOTO OSAMU SUZUKI YASUYOSHI KIRYU TOSHIFUMI HIBI MASAYA ODA HIROMASA ISHII 《Journal of gastroenterology and hepatology》1996,11(7):681-685
An ultrastructural study of the colonic mucosa was performed in four patients with antibiotic-associated haemorrhagic colitis and new findings are reported. Colonoscopy was performed and biopsy specimens were obtained within 24 h of the onset of bloody diarrhoea. Colonoscopy demonstrated diffuse oedematous and haemorrhagic mucosa with erosions and white coat. Light microscopy revealed mucosal haemorrhage and inflammatory cell infiltration. Ultrastructurally, platelet aggregation was frequently present in the lumina of colonic mucosal capillaries, causing engorgement of red blood cells in adjacent microvessels. Mild to severe damage was observed in capillary endothelial cells, including discontinuity of basement membranes, gaps between endothelial cells and the destruction of capillaries. There was no evidence of microvascular spasm. In conclusion, our findings suggest that antibiotics directly or indirectly cause microcirculatory disturbances, which result in tissue damage and haemorrhage, in the colonic mucosa. 相似文献
2.
TAKATSUGU OKEGAWA MANAMI KINJO MASAYA OHTA ICHIRO MIURA SHIGEO HORIE KIKUO NUTAHARA EIJI HIGASHIHARA 《International journal of urology》2003,10(4):201-206
OBJECTIVES: We determine whether the different molecular forms of prostate-specific antigen (PSA) and other PSA variables can predict prostate cancer in men undergoing repeat prostate needle biopsy. METHODS: Between 1997 and 2001, repeat biopsy was performed in 97 patients who had undergone prior negative prostate biopsy. The ability of total PSA (tPSA), complexed PSA (cPSA), free PSA (fPSA), free-to-total PSA (fPSA/tPSA), free-to-complexed PSA (fPSA/cPSA), complexed-to-total PSA (cPSA/tPSA), tPSA density (tPSAD), cPSA density (cPSAD), transition zone tPSA density (tPSATZ) and transition zone cPSA density (cPSATZ) was assessed by univariate and multivariate analyzes as well as receiver operating characteristics (ROC) curves. RESULTS: Prostate cancer on repeat biopsy was detected in 24% of subjects (23 of 97) who had a negative initial biopsy. The PSA parameters cut-off to ensure a 96% sensitivity of cancer detection, were 29% using fPSA/tPSA, 32% using fPSA/cPSA, 0.18 ng/mL/cc using tPSATZ and 0.16 ng/mL/cc using cPSATZ. The fPSA/tPSA would have prevented 32% of negative biopsies, the fPSA/cPSA 28%, the tPSATZ 23% and the cPSATZ 30%. ROC curve analysis fPSA/tPSA, fPSA/cPSA ratios, tPSATZ and cPSATZ were significantly better predictors of repeat biopsy results than tPSA or cPSA, but there was no significant difference in the ROC curves among these four PSA parameters. In the multivariate logistic regression analysis these four PSA parameters were significant predictors for cancer detection in the repeat biopsy group (P < 0.001). CONCLUSION: fPSA/tPSA ratio, fPSA/cPSA ratio, tPSATZ and cPSATZ enhance the specificity of PSA testing compared to tPSA or cPSA when determining which patients should undergo repeat biopsy. 相似文献
3.
TAKAHARU ICHIKAWA AKIRA TAKAO DAISUKE MANABE MICHIHISA SAEGUSA RYUTA TANIMOTO KENJI ARAMAKI MASAYA YAMAMOTO TOSHIYA OKAZAKI 《International journal of urology》2004,11(9):755-762
BACKGROUND: Data on female partners' satisfaction are scarce, although there have been many articles on patient satisfaction after sildenafil citrate treatment. The aim of this study was to evaluate the satisfaction of female partners of patients receiving sildenafil citrate for their erectile dysfunction (ED) and to assess the female partners' sexual function. METHODS: Ninety-eight patients with ED were treated. Their female partners were asked to answer a questionnaire we have prepared to evaluate the efficacy of treatment, sexual satisfaction and changes in quality of life. It also included a question about female sexual function. From the results, the relationship between their female partner's satisfaction and efficacy of treatment, as well as female sexual function, were assessed. RESULTS: Thirty (31%) questionnaires were returned to us for analysis. Effectiveness of the treatment was acknowledged by 90% of the partners. An improvement in their partner's quality of life was noticed by 60% of the women. The majority (66.7%) of the female partners were satisfied with sildenafil citrate treatment and 20% were disappointed. Moreover, 20% of the female partners were concerned about adverse events. Regarding female sexual function, some form of sexual dysfunction affected 46.7% of the women. Furthermore, a significant number (P = 0.0230) of the female partners disappointed with the treatment had some kind of sexual dysfunction. CONCLUSIONS: The results indicated that female partners reported relatively high levels of treatment satisfaction. Female partners' sexual function and anxiety regarding adverse events should be evaluated when their satisfaction with sildenafil citrate treatment is poor despite an improvement of erectile function. 相似文献
4.
IMARI MIMURA HIROSHI NISHI NAOBUMI MISE MASAYA MORI TOKUICHIRO SUGIMOTO 《Nephrology (Carlton, Vic.)》2010,15(5):549-554
Aim: In end‐stage renal disease (ESRD) patients, left ventricular hypertrophy (LVH) is common and a risk for cardiovascular events. LVH is geometrically classified into two major groups, concentric and eccentric, and accumulating evidence suggests eccentric LVH has a more negative effect than concentric LVH on ESRD outcome. However, there have been very few studies on the cardiac findings from ESRD patient autopsy in which the relationship between LVH geometry and mortality was analyzed. Methods: An observational study was performed with the autopsy findings in 30 haemodialysis patient cases between 2001 and 2006 at Mitsui Memorial Hospital, Tokyo. Between those who died of a cardiovascular cause and those who died of non‐cardiovascular causes, we compared the heart/bodyweight ratio, left ventricular dilatation, and the extent of fibrosis of the left ventricle. Results: Heart/bodyweight ratio was significantly higher (P < 0.0001) in the cardiovascular mortality group (n = 11, 11.7 ± 2.5 g/kg) compared to the non‐cardiac cause of death group (n = 19, 8.05 ± 0.7 g/kg). The dilatation of the left ventricle was significantly more frequent in the cardiovascular than the non‐cardiac cause of death group (P = 0.016). Additionally, the fibrotic area of left ventricular cross‐section was larger in the cardiovascular (1.63 ± 1.6%) than the non‐cardiac group (0.83 ± 1.7%, P = 0.04). Conclusion: This autopsy study indicates that eccentric LVH in haemodialysis patients is closely associated with cardiovascular mortality. LVH geometry, as well as LVH severity, is worthy of consideration as a clinical predictor for cardiovascular mortality. 相似文献
5.
AKIHIKO MATSUMOTO YUTAKA NAGATOMI MASATO SAKAI MASAYA OSHI 《International journal of urology》2004,11(9):789-791
Torsion of the hernia sac is a rare disease that presents as acute scrotum in children. Including the present case, only six cases have been reported in the English literature. We report a 10-year-old boy who presented with pain and swelling of his right scrotum. Ultrasonography revealed a hypoechoic region adjacent to the normal right testis. The inflammatory changes of the right scrotum deteriorated. The patient underwent surgery and a necrotic cyst was recognized within a hydrocele of the scrotum. The cyst was not connected with the testis or epididymis and was twisted at an angle of 270 degrees. The cause of the necrotic cyst observed was anatomical and pathological torsion of the hernia sac. 相似文献
6.
NORIO NISHI BUN-ICHIRO NAKAJIMA MASAYA MORISHIGE SEIICHI TOKURA 《Chemical biology & drug design》1986,27(3):261-268
Catalytic activities of linear, cyclic and polymeric peptides having the sequences of -Asp-ßAla-Gly-His-ßAla-Gly-(nonapeptide series) and -Asp-eAhx-Ser-eAhx-His-eAhx- (hexapeptide series) in the hydrolysis of various types of ester substrates were compared with one another and with that of poly (-His-ßAla-Gly) (Poly-3) which has no Ser or Asp residues. Hydrolytic activity of the hexapeptide series, the cyclic form in particular, was larger than that of the nonapeptide series in many cases such as in the hydrolysis of N-protected amino acid p-nitrophenyl esters (Z-Gly-ONp, Boc-Ala-ONp, Z- (l and d ) -Leu-ONp, Boc- (l and ) -Phe-ONp) and anionic 3-nitro-4-acetoxybenzoic acid ( NABA ). The activities of the polymeric peptides were generally smaller than those of the linear or cyclic peptides. None of the peptides showed the remarkable activity to the hydrophobic substrate with long chain, p-nitrophenyl laurate ( PNPL ), and they were almost inactive to bulky p-nitrophenyl trimethylacetate ( PNPTMA ) and cationic 3-acetoxy-N-trimethylanilinium iodide ( ANTI ). Enantiomer-selectivity in the hydrolysis of N-protected amino acid p-nitrophenyl esters and solvent isotope effect in the hydrolysis of p-nitrophenyl acetate ( PNPA ) are also reported. 相似文献
7.
Plasmacytoid urothelial carcinoma of the bladder 总被引:1,自引:0,他引:1
TAKUROU KOHNO MASAYA KITAMURA HIDEYUKI AKAI MINATO TAKAHA KUNIMITSU KAWAHARA TOSHITUGU OKA 《International journal of urology》2006,13(4):485-486
We report the first case of a pathological complete response for plasmacytoid urothelial carcinoma of the bladder. A 76-year-old man was diagnosed with plasmacytoid urothelial carcinoma (T4, N0, M0) by the microscopically plasmacytoid appearance of the specimen from the transurethral resection. Immunohistochemical studies were positive for epithelial markers and negative for lymphoid markers. Two cycles of systemic chemotherapy were performed with methotrexate, etoposide, vinblastine, and cisplatin, followed by radical cystectomy. The pathological examination revealed no residual cancer cells in the resected specimen. 相似文献
8.
Efficacy and Safety of Apixaban in the Patients Undergoing the Ablation of Atrial Fibrillation
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TOMOYUKI NAGAO M.D. YASUYA INDEN M.D. Ph.D. MASAYUKI SHIMANO M.D. Ph.D. MASAYA FUJITA M.D. SATOSHI YANAGISAWA M.D. HIROYUKI KATO M.D. SHINJI ISHIKAWA M.D. AYA MIYOSHI M.D. SATOSHI OKUMURA M.D. SHIOU OHGUCHI M.D. TOSHIHIKO YAMAMOTO M.D. NAOKI YOSHIDA M.D. Ph.D. MAKOTO HIRAI M.D. Ph.D. TOYOAKI MUROHARA M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2015,38(2):155-163
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10.
HIDENOBU MIURA AKIRA TSUJIMURA KENJI NISHIMURA MASAYA KITAMURA NOBUYUKI KONDOH MASAMI TAKEYAMA HIDEKI FUJIOKA MASAHARU SADA TAKAYUKI TSUJI KIYOMI MATSUMIYA SHIRO TAKAHARA AKIHIKO OKUYAMA 《The Journal of urology》1998,159(6):1939-1941