全文获取类型
收费全文 | 3822篇 |
免费 | 248篇 |
国内免费 | 93篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 246篇 |
妇产科学 | 89篇 |
基础医学 | 472篇 |
口腔科学 | 79篇 |
临床医学 | 463篇 |
内科学 | 910篇 |
皮肤病学 | 111篇 |
神经病学 | 187篇 |
特种医学 | 448篇 |
外科学 | 296篇 |
综合类 | 84篇 |
预防医学 | 258篇 |
眼科学 | 33篇 |
药学 | 226篇 |
2篇 | |
中国医学 | 16篇 |
肿瘤学 | 227篇 |
出版年
2023年 | 29篇 |
2022年 | 30篇 |
2021年 | 55篇 |
2020年 | 40篇 |
2019年 | 56篇 |
2018年 | 98篇 |
2017年 | 68篇 |
2016年 | 73篇 |
2015年 | 91篇 |
2014年 | 131篇 |
2013年 | 162篇 |
2012年 | 158篇 |
2011年 | 145篇 |
2010年 | 169篇 |
2009年 | 142篇 |
2008年 | 142篇 |
2007年 | 168篇 |
2006年 | 151篇 |
2005年 | 157篇 |
2004年 | 103篇 |
2003年 | 87篇 |
2002年 | 81篇 |
2001年 | 84篇 |
2000年 | 67篇 |
1999年 | 69篇 |
1998年 | 140篇 |
1997年 | 165篇 |
1996年 | 149篇 |
1995年 | 119篇 |
1994年 | 121篇 |
1993年 | 107篇 |
1992年 | 59篇 |
1991年 | 69篇 |
1990年 | 56篇 |
1989年 | 73篇 |
1988年 | 59篇 |
1987年 | 59篇 |
1986年 | 59篇 |
1985年 | 62篇 |
1984年 | 38篇 |
1983年 | 23篇 |
1982年 | 28篇 |
1981年 | 30篇 |
1980年 | 28篇 |
1979年 | 11篇 |
1978年 | 13篇 |
1977年 | 26篇 |
1976年 | 31篇 |
1975年 | 20篇 |
1974年 | 10篇 |
排序方式: 共有4163条查询结果,搜索用时 15 毫秒
1.
JM Martín† L Calduch† C Monteagudo‡ I Molina† D Ramón† V Alonso† E Jordᆠ《Journal of the European Academy of Dermatology and Venereology》2006,20(4):428-431
Cutaneous plasmacytosis is a rare disorder characterized by a benign proliferation of mature plasma cells that appears as multiple dark-brown to purplish skin lesions, often associated with polyclonal hypergammaglobulinaemia. We present the case of a 55-year-old Caucasian man who suffered from a cutaneous plasmacytosis associated with two different carcinomas. Cutaneous plasmacytosis seems to be a reactive process because most cases reported are not associated with any apparent underlying disease. Nevertheless, because few reported cases were associated with malignancies, screening of additional neoplasms would be justified. 相似文献
2.
A case-referent study of lung cancer, occupational exposures and smoking. II. Role of asbestos exposure 总被引:6,自引:0,他引:6
H Kjuus R Skjaerven S Lang?rd J T Lien T Aamodt 《Scandinavian journal of work, environment & health》1986,12(3):203-209
In a hospital-based case-referent study of 176 incident lung cancer cases, ascertained during a five-year period from two county hospitals, the role of asbestos exposure and smoking has been studied. Information on asbestos exposure was obtained from personal interviews, and allocated to four exposure categories, according to the intensity and duration of the exposure. Twenty-five percent of the cases and 10% of the referents had been moderately to heavily exposed to asbestos during their working career. A statistically significant trend in risk ratio related to the degree of exposure was observed, with a more than fourfold risk among the heavily exposed. The strongest association was found between asbestos exposure and small cell carcinoma, and the weakest association between asbestos exposure and adenocarcinoma. Very high risk ratios were observed among asbestos-exposed subjects who were heavy smokers, and the interaction observed between asbestos and smoking conformed more closely to a multiplicative model than to an additive one. The results suggest that the observed association between lung cancer and occupational exposures in this study was, to a large extent, due to asbestos exposure. Information on such exposure was missing in 90% of the medical records of these patients. 相似文献
3.
JM Vilanova J Figueras-Aloy J Roselló G Gómez E Gelpí R Jiménez 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(5):588-592
The aim of this study was to evaluate the cerebral synthesis of eicosanoids in the asphyctic newborn and to investigate the relation between the prostanoid profiles in cerebrospinal fluid (CSF) and the appearance and severity of hypoxic-ischaemic encephalopathy (HIE). Levels of 6-keto-PGF 1-α, TXB2 , PGE2 and PGF2-α in CSF were measured in 40 full term newborns during the first day of life. Thirty of these newborns had birth asphyxia and were divided into three groups: 10 without HIE, 12 with mild HIE and 8 with moderate-severe HIE. They were compared to a control group of 10 non-hypoxic newborns. Determinations of the metabolites in CSF were performed by RIA and expressed as pg/ml (mean ± SD). The CSF TXB2 (thromboxane A2 metabolite) in asphyxiated newborns was always higher than in the control group (28.12 ± 10.6), and related to the severity of HIE ( p = 0:005): without HIE (50.84 ± 16.4; p = 0:02), mild HIE (80.65 ± 12.64; p ± 0:01) and moderate-severe HIE (178.14 ± 20.5; p < 0:01). The CSF 6-keto-PGF 1-α (prostacyclin metabolite) in asphyxiated newborns was always higher than in the control group (80.55 ± 12.56), but indirectly related to the severity of HIE: without HIE (240.95 ± 28.12; p < 0:01), mild HIE (183.65 ± 30.1; p < 0:01) and moderate-severe HIE (140.55 ± 25.12; p < 0:01). In the moderate-severe HIE group, the increase in TXB2 was higher than the rise in 6-keto-PGF 1-α . 相似文献
4.
5.
6.
7.
8.
9.
I A Cliffe E L Lien H L Mansell K E Steiner R S Todd A C White R M Black 《Journal of medicinal chemistry》1992,35(7):1169-1175
A series of pyrimido[1,2-a]indoles were synthesized and studied for their hypoglycemic activity following oral administration at a standard dose of 100 mg/kg to fed rats. The effect of 10-alkoxyalkyl, 10-alkyl, 10-aryl, and 3,3-dialkyl substitution on the activity of 10-hydroxypyrimido[1,2-a]indoles was investigated. Relative potencies of a number of the most active compounds were defined by three-point dose-response studies. The most potent compounds were those with either 3,3-dimethyl substituents, compounds 21, 22, and 38, or 3,3-spirocyclohexane substituents, compounds 39 and 49. 10-Aminopyrimido[1,2-a]indoles were in general less active than the 10-hydroxy analogues, and potency was further decreased by derivatizing the 10-amino group. The most potent 10-amino derivatives were 57 and 58. 相似文献
10.