全文获取类型
收费全文 | 5870篇 |
免费 | 291篇 |
国内免费 | 64篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 267篇 |
妇产科学 | 271篇 |
基础医学 | 940篇 |
口腔科学 | 88篇 |
临床医学 | 463篇 |
内科学 | 1037篇 |
皮肤病学 | 94篇 |
神经病学 | 212篇 |
特种医学 | 614篇 |
外国民族医学 | 1篇 |
外科学 | 937篇 |
综合类 | 93篇 |
一般理论 | 1篇 |
预防医学 | 225篇 |
眼科学 | 47篇 |
药学 | 453篇 |
中国医学 | 4篇 |
肿瘤学 | 446篇 |
出版年
2022年 | 32篇 |
2021年 | 56篇 |
2020年 | 33篇 |
2019年 | 51篇 |
2018年 | 79篇 |
2017年 | 49篇 |
2016年 | 67篇 |
2015年 | 80篇 |
2014年 | 102篇 |
2013年 | 163篇 |
2012年 | 245篇 |
2011年 | 215篇 |
2010年 | 183篇 |
2009年 | 166篇 |
2008年 | 271篇 |
2007年 | 307篇 |
2006年 | 283篇 |
2005年 | 252篇 |
2004年 | 205篇 |
2003年 | 174篇 |
2002年 | 187篇 |
2001年 | 144篇 |
2000年 | 159篇 |
1999年 | 132篇 |
1998年 | 104篇 |
1997年 | 113篇 |
1996年 | 146篇 |
1995年 | 94篇 |
1994年 | 93篇 |
1993年 | 88篇 |
1992年 | 87篇 |
1991年 | 87篇 |
1990年 | 110篇 |
1989年 | 148篇 |
1988年 | 116篇 |
1987年 | 114篇 |
1986年 | 121篇 |
1985年 | 126篇 |
1984年 | 53篇 |
1983年 | 63篇 |
1982年 | 42篇 |
1981年 | 51篇 |
1980年 | 45篇 |
1979年 | 53篇 |
1978年 | 48篇 |
1977年 | 40篇 |
1976年 | 40篇 |
1975年 | 40篇 |
1926年 | 38篇 |
1924年 | 42篇 |
排序方式: 共有6225条查询结果,搜索用时 62 毫秒
1.
2.
3.
Seppo W. Langer 《Current oncology reports》2010,12(4):242-246
Extravasation of chemotherapy is a feared complication of anticancer therapy. The accidental leakage of cytostatic agents
into the perivascular tissues may have devastating short-term and long-term consequences for patients. In recent years, the
increased focus on chemotherapy extravasation has led to the development of international guidelines that have proven useful
tools in daily clinical practice. Moreover, the tissue destruction in one of the most dreaded types of extravasation (ie,
anthracycline extravasation) now can effectively be prevented with a specific antidote, dexrazoxane. 相似文献
4.
Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET. 总被引:1,自引:0,他引:1
Jens P Bankstahl Claudia Kuntner Aiman Abrahim Rudolf Karch Johann Stanek Thomas Wanek Wolfgang Wadsak Kurt Kletter Markus Müller Wolfgang L?scher Oliver Langer 《Journal of nuclear medicine》2008,49(8):1328-1335
The multidrug efflux transporter P-glycoprotein (P-gp) is expressed in high concentrations at the blood-brain barrier (BBB) and is believed to be implicated in resistance to central nervous system drugs. We used small-animal PET and (R)-11C-verapamil together with tariquidar, a new-generation P-gp modulator, to study the functional activity of P-gp at the BBB of rats. To enable a comparison with human PET data, we performed kinetic modeling to estimate the rate constants of radiotracer transport across the rat BBB. METHODS: A group of 7 Wistar Unilever rats underwent paired (R)-11C-verapamil PET scans at an interval of 3 h: 1 baseline scan and 1 scan after intravenous injection of tariquidar (15 mg/kg, n = 5) or vehicle (n = 2). RESULTS: After tariquidar administration, the distribution volume (DV) of (R)-11C-verapamil was 12-fold higher than baseline (3.68 +/- 0.81 vs. 0.30 +/- 0.08; P = 0.0007, paired t test), whereas the DVs were essentially the same when only vehicle was administered. The increase in DV could be attributed mainly to an increased influx rate constant (K1) of (R)-11C-verapamil into the brain, which was about 8-fold higher after tariquidar. A dose-response assessment with tariquidar provided an estimated half-maximum effect dose of 8.4 +/- 9.5 mg/kg. CONCLUSION: Our data demonstrate that (R)-11C-verapamil PET combined with tariquidar administration is a promising approach to measure P-gp function at the BBB. 相似文献
5.
Tendon injuries of the hand, especially flexor tendon injuries, should be treated by specially trained surgeons. Tendon injuries should be treated immediately to avoid joint stiffness or tendon adhesions, which arise predominantly at the tendon laceration. In addition to a professional operation, postoperative management is also important. As with surgery, specially trained physiotherapists should supervise the active or passive mobilization after tendon repair. A close cooperation between physiotherapist and physician is mandatory for an optimal result. 相似文献
6.
Frau Dr. K. Sternberg C. Selent N. Hakanßon J. Töllner T. Langer H. Seiter K.-P. Schmitz 《Der Urologe. Ausg. A》2004,43(10):1200-1208
The scope of our research is the development of polymer-based bioabsorbable stents for urologic applications and in vitro testing of tissue reactions of cultured ureteral and urethral segments induced by implanted polymer stent prototypes. For these purposes a tissue cultivation model was developed using selected techniques of tissue engineering. Essential advantages of degradable over nondegradable urethral stents are elimination of the adverse extraction of epithelialized stents and the potential for recovery of organ-specific functionality. Moreover, the biocompatibility of a degradable urethral stent could potentially reduce the risk of restenosis due to hyperplasia and could be used, even repeatedly, for the treatment of a number of subvesical obstructions. For the treatment of tumor-induced strictures, application of degradable polymer stents coated with cytostatic drugs may be possible. The mechanical effect of the drug-loaded stent as a “place holder” could be complemented by adjuvant or palliative approaches such as local chemotherapy. We have developed and tested in vitro a degradable urethral stent incorporated with the model drug methotrexate for local drug delivery (LDD) by diffusion and during stent degradation. 相似文献
7.
8.
9.
Leonidas JC; Berdon WE; Valderrama E; Neveling U; Schuval S; Weiss SJ; Hilfer C; Godine L 《Radiology》1996,198(2):377
10.