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1.
Selective homing of phenotypically lytic cells within nasopharyngeal carcinoma biopsies: numerous CD8- and CD16-positive cells in the tumor. 总被引:1,自引:0,他引:1
M Lakhdar M H Ben Aribia M Maalej A Ladgham 《International journal of cancer. Journal international du cancer》1991,48(1):57-61
We present a comparative analysis of cell-mediated immunity between circulating lymphocytes and tumor-infiltrating lymphocytes (TIL) from patients with nasopharyngeal carcinoma (NPC). Phenotypic analysis using a panel of monoclonal antibodies (MAbs) to define lymphocytic subsets has revealed a selective homing of phenotypically lytic cells such as CD8- and CD16-positive cells, but a low percentage of macrophages when compared to PBL of NPC patients. Also, PBL and TIL contain an equivalent percentage of activated T-lymphocytes expressing HLA-DR molecules and IL-2 receptors. Functionally, TIL exhibit an abolished NK-cell activity and concomitant decrease of proliferative response to phytohemagglutinin (PHA) and concanavalin A (ConA) stimulation when compared with PBL. 相似文献
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Cdric Farges Olivier Cointault Marlne Murris Laurence Lavayssiere Shrazade Lakhdar‐Ghazal Arnaud Del Bello Anne‐Laure Hebral Laure Esposito Marie‐Batrice Nogier Federico Sallusto Xavier Iriart Elena Charpentier Joelle Guitard Fabrice Muscari Camille Dambrin Lydie Porte Nassim Kamar Sophie Cassaing Stanislas Faguer 《Transplant infectious disease》2020,22(1)
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Frederic De Leeuw Ingrid Breuskin Muriel Abbaci Odile Casiraghi Haïtham Mirghani Aïcha Ben Lakhdar Corinne Laplace-Builhé Dana Hartl 《World journal of surgery》2016,40(9):2131-2138
Background
Parathyroid glands (PGs) can be particularly hard to distinguish from surrounding tissue and thus can be damaged or removed during thyroidectomy. Postoperative hypoparathyroidism is the most common complication after thyroidectomy. Very recently, it has been found that the parathyroid tissue shows near-infrared (NIR) auto-fluorescence which could be used for intraoperative detection, without any use of contrast agents. The work described here presents a histological validation ex vivo of the NIR imaging procedure and evaluates intraoperative PG detection by NIR auto-fluorescence using for the first time to our knowledge a commercially available clinical NIR imaging device.Methods
Ex vivo study on resected operative specimens combined with a prospective in vivo study of consecutive patients who underwent total or partial thyroid, or parathyroid surgery at a comprehensive cancer center. During surgery, any tissue suspected to be a potential PG by the surgeon was imaged with the Fluobeam 800 ® system. NIR imaging was compared to conventional histology (ex vivo) and/or visual identification by the surgeon (in vivo).Results
We have validated NIR auto-fluorescence with an ex vivo study including 28 specimens. Sensitivity and specificity were 94.1 and 80 %, respectively. Intraoperative NIR imaging was performed in 35 patients and 81 parathyroids were identified. In 80/81 cases, the fluorescence signal was subjectively obvious on real-time visualization. We determined that PG fluorescence is 2.93 ± 1.59 times greater than thyroid fluorescence in vivo.Conclusions
Real-time NIR imaging based on parathyroid auto-fluorescence is fast, safe, and non-invasive and shows very encouraging results, for intraoperative parathyroid identification.6.
Ouarda Taleb-Belkadi Hadjer Chaib Lakhdar Zemour Azzedine Fatah Belkacem Chafi 《Gynecological endocrinology》2016,32(12):982-985
Objective: To evaluate the effect of perimenopause and postmenopause on lipid profile, inflammation, and oxidative stress in women.Methods: This cross-sectional study included 117 women (47?±?6 years) classified as perimenopausal (n?=?47), postmenopausal (n?=?40), or non-menopausal (n?=?30). In serum, we analyzed lipid profile, tumor necrosis factor-alpha (TNF-α), interleukin-1α (IL-1α), and C-reactive protein (CRP). Pro-oxidant status was assessed by thiobarbituric acid reactive substances (TBARS) and protein carbonyls. Antioxidant defense was performed by analysis of superoxide dismutase (SOD) and catalase activities.Results: Compared to non-menopausal women, triacylglycerols (TG) were similar, total cholesterol and LDL-C were higher in perimenopausal and postmenopausal women, while HDL-C concentrations were decreased. TNF-α and IL-1α were higher in postmenopausal women, while CRP concentrations were elevated in both peri-and postmenopausal women (p?0.05). TBARS and carbonyls were increased in peri- and postmenopausal women (p?0.05). SOD and CAT activities were decreased in postmenopausal women (p?0.05) and elevated in perimenopausal women.Conclusion: Menopausal transition and postmenopause were associated with dyslipidemia, inflammation, and unbalanced oxidative status exposing women to cardiovascular risk. 相似文献
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Mahmoud Nassar Nso Nso Sofia Lakhdar Ravali Kondaveeti Chandan Buttar Harangad Bhangoo Mahmoud Awad Naveen Siddique Sheikh Karim M Soliman Most Sirajum Munira Farshid Radparvar Vincent Rizzo Ahmed Daoud 《World Journal of Transplantation》2022,12(3):42-54
It has been reported that up to 90% of organ transplant recipients have suboptimal blood pressure control. Uncontrolled hypertension is a well-known culprit of cardiovascular and overall morbidity and mortality. In addition, rigorous control of hypertension after organ transplantation is a crucial factor in prolonging graft survival. Nevertheless, hypertension after organ transplantation encompasses a broader range of causes than those identified in non-organ transplant patients. Hence, specific management awareness of those factors is mandated. An in-depth understanding of hypertension after organ transplantation remains a debatable issue that necessitates further clarification. This article provides a comprehensive review of the prevalence, risk factors, etiology, complications, prevention, and management of hypertension after organ transplantation. 相似文献
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Ibahioin K El Malki M Chellaoui A Bertal A Hilmani S Lakhdar A Naja A Sami A Achouri M Ouboukhlik A El Kamar A El Azhari A 《Neuro-Chirurgie》2004,50(5):527-532
Tuberculosis of the central nervous system is uncommon. The intramedullary localization is exceptional. We report five cases of intramedullary tuberculosis observed in four women and one man with a mean age of 43 years. Two patients had a prior history of tuberculosis. Spinal cord compression was found clinically in all cases. The spinal MRI visualized the tuberculoma in all patients; two had a double tumor. Complete removal of the tuberculoma was possible in only one patient. Outcome was stationary for four patients. 相似文献