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Finite-element models of the human head 总被引:9,自引:0,他引:9
L. Voo PhD S. Kumaresan F. A. Pintar N. Yoganandan A. Sances Jr. 《Medical & biological engineering & computing》1996,34(5):375-381
A review is presented of the existing finite-element (FE) models for the biomechanics of human head injury. Finite element
analysis can be an important tool in describing the injury biomechanics of the human head. Complex geometric and material
properties pose challenges to FE modelling. Various assumptions and simplifications are made in model development that require
experimental validation. More recent models incorporate anatomic details with higher precision. The cervical vertebral column
and spinal cord are included. Model results have been more qualitative than quantitative owing to the lack of adequate experimental
validation. Advances include transient stress distribution in the brain tissue, frequency responses, effects of boundary conditions,
pressure release mechanism of the foramen magnum and the spinal cord, verification of rotation and cavitation theories of
brain injury, and protective effects of helmets. These theoretical results provide a basic understanding of the internal biomechanical
responses of the head under various dynamic loading conditions. Basic experimental research is still needed to determine more
accurate material properties and injury tolerance criteria, so that FE models can fully exercise their analytical and predictive
power for the study and prevention of human head injury. 相似文献
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The p21-activated kinases signal through a number of cellular pathways fundamental to growth, differentiation and apoptosis.
A wealth of information has accumulated at an impressive pace in the recent past, both with regard to previously identified
targets for p21-activated kinases that regulate the actin cytoskeleton and cellular stress pathways and with regard to newly
identified targets and their role in cancer. Emerging data also provide new clues towards a previously unappreciated link
between these various cellular processes. The present review attempts to provide a quick tutorial to the reader about the
evolving significance of p21-activated kinases and small GTPases in breast cancer, using information from mouse models, tissue
culture studies, and human materials. 相似文献
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The clinical relevance of steroid hormone receptor corepressors. 总被引:2,自引:0,他引:2
Rakesh Kumar Anupama E Gururaj Ratna K Vadlamudi Suresh K Rayala 《Clinical cancer research》2005,11(8):2822-2831
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Rajesh Vedachalam Kumaresan Yamini Rengaraj Venkatesh Narendran Kalpana Chandrashekaran Shivkumar Madhu Shekhar Aravind Haripriya Ravilla Sathya 《Indian journal of ophthalmology》2022,70(6):2153
Purpose:To analyze the reasons for delay in cataract surgery in patients with advanced cataracts during the COVID-19 pandemic.Methods:This was a prospective, cross-sectional, multicenter questionnaire study which included patients with mature cataract, nuclear sclerotic cataract grade IV, and cataracts with best corrected visual acuity (BCVA) <5/60, during the COVID-19 pandemic from December 2020 to April 2021. Reasons for delay in presentation to the hospital were analyzed.Results:One thousand four hundred seventy two patients were recruited with advanced cataracts. Absence of ophthalmic care nearby (44.2%), lack of awareness regarding elective surgeries (42.6%), lack of public transportation (37%), fear of contracting COVID-19 (23.4%), and waiting for outreach camps (20.4%) were found to be the reasons behind the delay in cataract surgery. 53.7% of the patients had worsening of defective vision and 55.3% of them had difficulty in carrying out activities of family living. 30.8% of the patients faced difficulty in commuting and 8.4% of the patients suffered a fall during this pandemic due to worsening of the visual acuity.Conclusion:The lockdown imposed during the pandemic has created a significant backlog of patients who are progressing to advanced cataracts due to lack of ophthalmic care nearby, lack of awareness regarding elective surgeries, lack of public transportation, and no outreach camps. Proactive measures to deal with this backlog are of utmost need to prevent blindness due to cataract. 相似文献
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Thallium 201 exercise redistribution planar myocardial perfusion scan using semiquantitative technique was performed in 80 symptomatic patients undergoing coronary angiography. Out of the 240 vessels studied by angiography, more than 70% luminal narrowing was detected in 87 vessels, borderline stenosis was found in 49 arteries and the remaining 104 vessels were normal. Thallium scan correctly identified the significant stenosis in 76 vessels and the absence of stenosis in 102 vessels. In addition, perfusion abnormality was found in relation with 21 vessels of borderline stenosis. The sensitivity and specificity of Thallium scan were estimated as 92% and 95% for left anterior descending artery (LAD), 79% and 98% for left circumflex artery (LCX), 88% and 100% for right coronary artery (RCA) and 87% and 98% for all coronary arteries combined together (ACA). 相似文献
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