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排序方式: 共有105条查询结果,搜索用时 15 毫秒
1.
Obstetric outcome in 232 ovum donation pregnancies 总被引:3,自引:0,他引:3
Hossam I. Abdalla Consultant Anne Billett Clinical Research Fellow rew K. S. Kan Clinical Research Fellow Sabah Baig Clinical Research Fellow Marie Wren Infertility Specialist Lena Korea Ovum Donation Co-ordinator John W. W. Studd Consultant 《BJOG : an international journal of obstetrics and gynaecology》1998,105(3):332-337
2.
Charalampia G. Korea Giuliana Balsamo Alfredo Pezzicoli Christina Merakou Simona Tavarini Fabio Bagnoli Davide Serruto Meera Unnikrishnan 《Infection and immunity》2014,82(10):4144-4153
The opportunistic pathogen Staphylococcus aureus is one of the major causes of health care-associated infections. S. aureus is primarily an extracellular pathogen, but it was recently reported to invade and replicate in several host cell types. The ability of S. aureus to persist within cells has been implicated in resistance to antimicrobials and recurrent infections. However, few staphylococcal proteins that mediate intracellular survival have been identified. Here we examine if EsxA and EsxB, substrates of the ESAT-6-like secretion system (Ess), are important during intracellular S. aureus infection. The Esx proteins are required for staphylococcal virulence, but their functions during infection are unclear. While isogenic S. aureus esxA and esxB mutants were not defective for epithelial cell invasion in vitro, a significant increase in early/late apoptosis was observed in esxA mutant-infected cells compared to wild-type-infected cells. Impeding secretion of EsxA by deleting C-terminal residues of the protein also resulted in a significant increase of epithelial cell apoptosis. Furthermore, cells transfected with esxA showed an increased protection from apoptotic cell death. A double mutant lacking both EsxA and EsxB also induced increased apoptosis but, remarkably, was unable to escape from cells as efficiently as the single mutants or the wild type. Thus, using in vitro models of intracellular staphylococcal infection, we demonstrate that EsxA interferes with host cell apoptotic pathways and, together with EsxB, mediates the release of S. aureus from the host cell. 相似文献
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4.
Sunwoo S Kim YS Cho BL Cheon KS Seo HG Rho MK Cheong YS Hong MH Kim SW Kim DH;Korea Post-Marketing Surveillance Research Group 《International journal of impotence research》2005,17(1):71-75
In order to investigate the safety and efficacy of sildenafil prescribed in primary care, a post-marketing surveillance study was undertaken. A total of 651 men with erectile dysfunction (ED) were enrolled from 31 family physicians in Korea from December 1999 to July 2002. Patients were regularly followed up to ascertain the safety and efficacy of sildenafil. Of the 651 patients enrolled, 572 (87.9%) returned for safety evaluation and efficacy assessment. In all, 458 (80.1%) of 572 patients reported improved erectile function with sildenafil. Hypertension, diabetes and low-dose sildenafil were associated with poor efficacy. A total of 71 adverse events were reported among 56 patients (8.6%), with the most frequent being hot flushes (5.6%), followed by headache (2.6%), palpitation (1.0%), anxiety (0.5%) and elevated ALT (0.5%). Only six patients (1.0%) discontinued sildenafil as a direct result of adverse events. These results suggest that sildenafil prescribed by primary care physicians was well tolerated and improved erectile function in patients with ED. 相似文献
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Jang Hoon Lee Dong Heon Yang Hun Sik Park Yongkeun Cho Myung Ho Jeong Young Jo Kim Kee-Sik Kim Seung Ho Hur In Whan Seong Taek Jong Hong Myeong Chan Cho Chong Jin Kim Jae-Eun Jun Wee-Hyun Park Shung Chull Chae for the Korea Acute Myocardial Infarction Registry Investigators 《American heart journal》2010,159(6):1012-1019
7.
Cho KH Jeong MH Ahn Y Kim YJ Chae SC Hong TJ Seong IW Chae JK Kim CJ Cho MC Seung KB Park SJ;Korea Acute Myocardial Infarction Registry Investigators 《The American journal of cardiology》2010,106(8):1061-1068
The relation between low-density lipoprotein (LDL) cholesterol levels and clinical outcomes after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has not been described. A total of 9,571 eligible patients (mean age 62.6 ± 12.5 years, 6,967 men) who underwent PCI with a final diagnosis of AMI from the Korea Acute Myocardial Infarction Registry (KAMIR) were divided into 5 groups according to LDL cholesterol level: < 70, 70 to 99, 100 to 129, 130 to 159, and ≥ 160 mg/dl. Clinical outcomes in hospital and 1 and 12 months after PCI in patients with AMI were examined. Age and co-morbidities decreased as LDL cholesterol increased. Patients with higher LDL cholesterol levels had favorable hemodynamic status and laboratory findings. Lifesaving medications, including lipid-lowering drugs, were underused in patients with lower LDL cholesterol levels. Clinical outcomes in hospital and 1 and 12 months after PCI showed better results as LDL cholesterol increased, except for patients with LDL cholesterol levels ≥ 160 mg/dl. In a Cox proportional-hazards model, LDL cholesterol level was not an independent predictor of mortality at 12 months, after adjusting for clinical characteristics including demographics and biologic data. In conclusion, the cholesterol paradox in patients with AMI is related to confounding by baseline characteristics associated with survival. More intensive treatment including lipid-lowering therapy for AMI in patients with lower LDL cholesterol level may result in better clinical outcomes. 相似文献
8.
Cho JS Her SH Baek JY Park MW Kim HD Jeong MH Ahn Yk Chae SC Hur SH Hong TJ Kim YJ Seong IW Chae JK Rhew JY Chae IH Cho MC Bae JH Rha SW Kim CJ Choi D Jang YS Yoon J Chung WS Cho JG Seung KB Park SJ;Korea Acute Myocardial Infarction Registry Investigators 《Journal of Korean medical science》2010,25(11):1601-1608
The efficacy of low molecular weight heparin (LMWH) with low dose unfractionated heparin (UFH) during percutaneous coronary intervention (PCI) with or without glycoprotein (Gp) IIb/IIIa inhibitor compared to UFH with or without Gp IIb/IIIa inhibitor has not been elucidated. Between October 2005 and July 2007, 2,535 patients with ST elevation acute myocardial infarction (STEMI) undergoing PCI in the Korean Acute Myocardial Infarction Registry (KAMIR) were assigned to either of two groups: a group with Gp IIb/IIIa inhibitor (n=476) or a group without Gp IIb/IIIa inhibitor (n=2,059). These groups were further subdivided according to the use of LMWH with low dose UFH (n=219) or UFH alone (n=257). The primary end points were cardiac death or myocardial infarction during the 30 days after the registration. The primary end point occurred in 4.1% (9/219) of patients managed with LMWH during PCI and Gp IIb/IIIa inhibitor and 10.8% (28/257) of patients managed with UFH and Gp IIb/IIIa inhibitor (odds ratio [OR], 0.290; 95% confidence interval [CI], 0.132-0.634; P=0.006). Thrombolysis In Myocardial Infarction (TIMI) with major bleeding was observed in LMHW and UFH with Gp IIb/IIIa inhibitor (1/219 [0.5%] vs 1/257 [0.4%], P=1.00). For patients with STEMI managed with a primary PCI and Gp IIb/IIIa inhibitor, LMWH is more beneficial than UFH. 相似文献
9.
Hyung Ook Kim Seung Kwon Kim Byung Ho Son Chang Hak Yoo Hyun Pyo Hong Yong Kyun Cho Byung Ik Kim 《Hepatobiliary & Pancreatic Diseases International》2009,(6)
BACKGROUND:Although hepatic resection is widely accepted as a proper modality for treating hepatocellular carcinoma(HCC),a majority of patients are unable to undergo surgical resection due to various tumor and patient factors.Radiofrequency ablation(RFA)has mostly been used as a therapeutic alternative to resection for treating HCC.The objective of this study was to evaluate the results of intraoperative RFA for HCCs in locations difficult for a percutaneous approach.METHODS:Eight patients(male,seven;age,49... 相似文献
10.
Jang Hoon Lee Hun Sik Park Shung Chull Chae Yongkeun Cho Dong Heon Yang Myung Ho Jeong Young Jo Kim Kee-Sik Kim Seung Ho Hur In Whan Seong Taek Jong Hong Myeong Chan Cho Chong Jin Kim Jae Eun Jun Wee Hyun Park Korea Acute Myocardial Infarction Registry Investigators 《The American journal of cardiology》2009,104(2):182-189