全文获取类型
收费全文 | 1273篇 |
免费 | 95篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 86篇 |
妇产科学 | 22篇 |
基础医学 | 140篇 |
口腔科学 | 65篇 |
临床医学 | 127篇 |
内科学 | 276篇 |
皮肤病学 | 24篇 |
神经病学 | 71篇 |
特种医学 | 19篇 |
外科学 | 297篇 |
综合类 | 8篇 |
预防医学 | 105篇 |
眼科学 | 21篇 |
药学 | 45篇 |
中国医学 | 2篇 |
肿瘤学 | 41篇 |
出版年
2023年 | 9篇 |
2022年 | 25篇 |
2021年 | 45篇 |
2020年 | 19篇 |
2019年 | 33篇 |
2018年 | 19篇 |
2017年 | 24篇 |
2016年 | 19篇 |
2015年 | 27篇 |
2014年 | 38篇 |
2013年 | 45篇 |
2012年 | 58篇 |
2011年 | 69篇 |
2010年 | 45篇 |
2009年 | 32篇 |
2008年 | 60篇 |
2007年 | 62篇 |
2006年 | 58篇 |
2005年 | 54篇 |
2004年 | 55篇 |
2003年 | 50篇 |
2002年 | 46篇 |
2001年 | 29篇 |
2000年 | 28篇 |
1999年 | 34篇 |
1998年 | 11篇 |
1997年 | 9篇 |
1996年 | 12篇 |
1994年 | 10篇 |
1992年 | 16篇 |
1991年 | 22篇 |
1990年 | 29篇 |
1989年 | 12篇 |
1988年 | 19篇 |
1987年 | 19篇 |
1986年 | 17篇 |
1985年 | 10篇 |
1984年 | 13篇 |
1983年 | 11篇 |
1979年 | 18篇 |
1978年 | 10篇 |
1976年 | 9篇 |
1975年 | 8篇 |
1974年 | 11篇 |
1973年 | 13篇 |
1972年 | 10篇 |
1970年 | 8篇 |
1969年 | 16篇 |
1968年 | 12篇 |
1966年 | 7篇 |
排序方式: 共有1370条查询结果,搜索用时 15 毫秒
1.
2.
3.
Tori Smedal Hildegunn Lygren Kjell‐Morten Myhr Rolf Moe‐Nilssen Bente Gjelsvik Olav Gjelsvik Liv Inger Strand 《Physiotherapy research international》2006,11(2):104-116
Background and Purpose . Patients with multiple sclerosis (MS) tend to have movement difficulties, and the effect of physiotherapy for this group of patients has been subjected to limited systematic research. In the present study physiotherapy based on the Bobath concept, applied to MS patients with balance and gait problems, was evaluated. The ability of different functional tests to demonstrate change was evaluated. Method . A single‐subject experimental study design with ABAA phases was used, and two patients with relapsing–remitting MS in stable phase were treated. Tests were performed 12 times, three at each phase: A (at baseline); B (during treatment); A (immediately after treatment); and A (after two months). The key feature of treatment was facilitation of postural activity and selective control of movement. Several performance and self‐report measures and interviews were used. Results . After intervention, improved balance was shown by the Berg Balance Scale (BBS) in both patients, and improved quality of gait was indicated by the Rivermead Visual Gait Assessment (RVGA). The patients also reported improved balance and gait function in the interviews and scored their condition as ‘much improved’. Gait parameters, recorded by an electronic walkway, changed, but differently in the two patients. Among the physical performance tests the BBS and the RVGA demonstrated the highest change, while no or minimal change was demonstrated by the Rivermead Mobility Index (RMI) and Ratings of Perceived Exertion (RPE). Conclusion . The findings indicate that balance and gait can be improved after physiotherapy based on the Bobath concept, but this should be further evaluated in larger controlled trials of patients with MS. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
4.
5.
Complications of needle localization of foreign bodies and nonpalpable breast lesions 总被引:1,自引:0,他引:1
Needle-wire localization of foreign bodies and nonpalpable breast lesions is commonly used to allow for more accurate excision or biopsy. We present three examples of complications of the localization procedure: (1) wire migration into the chest wall with retained fragment, (2) transection of a wire during biopsy with retained hook fragment, and (3) wire migration within the thigh soft tissues with breakage at the hooked end. Recommendations to minimize the incidence of these complications and their sequelae include (1) bending the hookwire 90 degree at the skin surface following localization, (2) transferring the patient between the radiology suite and the operating room via a stretcher, with minimal movement of the body part localized, and (3) accounting for the entire length of wire by the surgeon, pathologist, and radiologist following the procedure to exclude retained fragments. 相似文献
6.
The effects of aldehyde fixation on tissue proteins was studied using SDS-polyacrylamide gel electrophoresis. Fixation with low concentrations of formaldehyde or glutaraldehyde had only a slight effect on the protein banding pattern. On the other hand, most of the original protein bands were absent after a short treatment with mixtures of formaldehyde and glutaraldehyde. Spectral absorption measurements showed a stronger absorption at both gamma = 280 nm and gamma = 235 nm with the glutaraldehyde-formaldehyde mixture than with glutaraldehyde alone. 相似文献
7.
K E Sletnes F Wisl?ff N Moe P O Dale 《Acta obstetricia et gynecologica Scandinavica》1992,71(2):112-117
The significance of antiphospholipid antibodies in pre-eclamptic women has not been thoroughly elucidated. The purpose of this study was to determine the proportion of pre-eclamptic women who were antiphospholipid antibody positive, and to elucidate the significance of these antibodies regarding growth retardation and neonatal outcome. Positive levels of anticephalin antibodies, which are antiphospholipid antibodies, were detected in 7 (19%) out of 37 pre-eclamptic women, as compared with none of 40 in a control group of normotensive women at similar stage of pregnancy (p = 0.004). The birthweight percentiles of the neonates of anticephalin antibody positive women were significantly lower than those of the neonates of anticephalin antibody negative women (p = 0.018). Four of 7 infants of anticephalin antibody positive women were growth retarded (less than 2.5th percentile). This was a significantly larger proportion than that for anticephalin antibody negative women (3/30) (p = 0.004). The 95% confidence interval for the difference between the two proportions was 0.10 to 0.85. Two of the 7 neonates of anticephalin antibody positive women died during the neonatal period, compared with none of the 30 neonates of anticephalin antibody negative women (p = 0.003). Thus, our study suggests that positive levels of anticephalin antibodies in pre-eclamptic women increase the risk for growth retardation and neonatal death. 相似文献
8.
Moe Sharon M.; O'Neill Kalisha D.; Reslerova Martina; Fineberg Naomi; Persohn Scott; Meyer Cristopher A. 《Nephrology, dialysis, transplantation》2004,19(11):2933
Nephrol Dial Transplant 2004; 19: 相似文献
9.
P. Lekic D. Kenny H. K. Moe E. Barrettt C. A. G. McCulloch 《Journal of periodontal research》1996,31(4):294-300
The survival rate of avulsed permanent teeth following replantation is affected primarily by the duration of the extra-alveolar period and the nature of the storage conditions. These factors are believed to strongly affect the viability of periodontal ligament (PL) cells but in vitro assays of cell viability based on vital dye assays are only weakly correlated with the tooth survival rate after replantation. The aim of the present study was to examine the relative dependence of cell membrane integrity, attachment and clonogenic capacity of human PL cells on the temperature and duration of the extra-alveolar period and the type of storage medium. Twenty-four premolar teeth were extracted for orthodontic reasons from 9 patients 11–18 years of age. Teeth were maintained at 4°C or 23°C for 15, 30, 60 or 120 min in either milk or dry conditions. Cell membrane integrity was determined by BCECF/AM dye inclusion. Plating efficiency was determined by measurement of cell attachment at 3 and 6 h. The clonogenic capacity of progenitor cells was estimated by limiting dilution and colony counts. For all assays teeth stored in milk at 4°C showed the highest percentages of BCECF positive, attached cells with clonogenic capacity. Increased storage time (15–120 min) was associated with a 50% relative reduction of BCECF staining and a 5-fold relative reduction of cell attachment regardless of storage conditions. However, the clonogenic capacity of progenitor cells decreased 25-fold over the same duration of storage. These data demonstrate that in vitro assays of clonogenic capacity are much more sensitive to extra-oral storage time and storage conditions than dye inclusion or cell attachment. We suggest that in comparison with in vitro measures of cell membrane integrity, the clonogenic capacity of PL cells is more closely linked to tooth survival rate, probably reflecting the capacity of PL progenitor cells to recolonize the root surface after replantation. 相似文献
10.
Diagnosis of norwalk virus infection by indirect enzyme immunoassay detection of salivary antibodies to recombinant norwalk virus antigen 总被引:1,自引:0,他引:1
Moe CL Sair A Lindesmith L Estes MK Jaykus LA 《Clinical and diagnostic laboratory immunology》2004,11(6):1028-1034
Simple diagnostic tests are needed for the detection of norovirus (NoV) outbreaks. Salivary antibody assays provide an attractive alternative to collecting and testing serum or stool samples. Antibodies to Norwalk virus (NV) in oral fluid samples were compared with NV antibodies in serum collected from 38 volunteers challenged with NV inoculum. Pre- and postchallenge (day 4, 8, 14, and 21) saliva and serum samples were examined by enzyme immunoassay (EIA) using recombinant NV antigen. Of 18 infected subjects (those who shed NV in stool or who demonstrated immunoglobulin G [IgG] seroconversion), 15 (83%) had > or =4-fold increases in NV-specific salivary IgA and 15 (83%) had > or =4-fold increases in NV-specific salivary IgG when prechallenge and postchallenge saliva samples were compared. When the results of the IgA and IgG assays were combined, all 18 infected subjects showed > or =4-fold increases in NV-specific salivary IgG or IgA postchallenge titers compared to their prechallenge titers. One of 19 uninfected subjects had a > or =4-fold increase in NV-specific salivary IgG. The sensitivity of the combined assay results was 100%, and the specificity was 95%. NV-specific salivary IgA titers peaked around 14 days postchallenge. NV-specific salivary IgG and serum IgG titers continued to rise through 21 days postchallenge. The application of this EIA to an elementary school outbreak indicated that 67% of the subjects with confirmed infections had >4-fold rises in anti-NoV IgA when an antigen in the same genetic cluster as the outbreak virus was used. This is the first documented mucosal antibody response to NoV in children. This EIA provides a useful approach for diagnosing NoV outbreaks. 相似文献