全文获取类型
收费全文 | 783篇 |
免费 | 51篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 18篇 |
妇产科学 | 29篇 |
基础医学 | 111篇 |
口腔科学 | 37篇 |
临床医学 | 80篇 |
内科学 | 114篇 |
皮肤病学 | 13篇 |
神经病学 | 112篇 |
特种医学 | 20篇 |
外科学 | 124篇 |
综合类 | 1篇 |
一般理论 | 2篇 |
预防医学 | 50篇 |
眼科学 | 3篇 |
药学 | 76篇 |
中国医学 | 5篇 |
肿瘤学 | 38篇 |
出版年
2023年 | 7篇 |
2022年 | 21篇 |
2021年 | 25篇 |
2020年 | 17篇 |
2019年 | 18篇 |
2018年 | 22篇 |
2017年 | 18篇 |
2016年 | 29篇 |
2015年 | 24篇 |
2014年 | 18篇 |
2013年 | 41篇 |
2012年 | 64篇 |
2011年 | 53篇 |
2010年 | 33篇 |
2009年 | 27篇 |
2008年 | 48篇 |
2007年 | 49篇 |
2006年 | 28篇 |
2005年 | 31篇 |
2004年 | 30篇 |
2003年 | 25篇 |
2002年 | 28篇 |
2001年 | 11篇 |
2000年 | 6篇 |
1999年 | 25篇 |
1998年 | 12篇 |
1997年 | 8篇 |
1996年 | 4篇 |
1995年 | 6篇 |
1994年 | 7篇 |
1993年 | 4篇 |
1992年 | 11篇 |
1991年 | 10篇 |
1990年 | 6篇 |
1989年 | 5篇 |
1988年 | 3篇 |
1987年 | 10篇 |
1986年 | 3篇 |
1985年 | 4篇 |
1983年 | 3篇 |
1982年 | 5篇 |
1980年 | 5篇 |
1977年 | 4篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1970年 | 4篇 |
1969年 | 2篇 |
1968年 | 3篇 |
排序方式: 共有835条查询结果,搜索用时 15 毫秒
1.
2.
Effect of constituents of burned skin and in vivo skin burning on the respiratory activity of rat liver mitochondria. 总被引:2,自引:0,他引:2
H Feifel G Bruchelt K Schmidt 《Burns : journal of the International Society for Burn Injuries》1992,18(4):308-312
The formation of toxic substances in the skin, due to the influence of thermal energy, is supposed to be one possible mechanism responsible for the high mortality rate after severe burns covering large areas of the body surface. The effects of low-molecular-weight volatile substances (dry distillates) generated after burning mouse skin were investigated. They led to reductions of the respiratory activity of rat liver mitochondria. Among other substances carbon disulphide, methylethylketone and pyrrole were isolated and characterized using gas chromatography. All of them had strong uncoupling effects on mitochondrial respiration. In a second study respiratory measurements were made on mitochondria from rats with 20-30 per cent TBSA full skin thickness burns. A decreased respiratory control ratio and thus uncoupling of mitochondrial respiration was found on days 1, 2 and 5 postburn. The basal mitochondrial respiration was significantly decreased on day 5, which could be important for the mortality mentioned above. Finally after cross-transplantations rats having burned skin grafted showed a reduction of the RCR when compared with rats with the unburned graft. Thus it can be concluded that toxic substances must have been present in burned skin. 相似文献
3.
Prof. Dr. G. Feifel 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1994,379(3):129-130
Ohne Zusammenfassung 相似文献
4.
Prepulse inhibition (PPI) of the startle reflex can be disrupted by drugs that act as agonists at the serotonin (5-HT) 2A receptor, such as DOI, and this effect is blocked by drugs that inhibit 5-HT2A transmission. We tested the effects of systemic administration of PD149163, a neurotensin agonist, on DOI-induced disruption of PPI in Sprague-Dawley rats. PD149163 completely and dose dependently blocked the PPI deficits produced by DOI. These findings suggest that, in addition to their established ability to inhibit dopamine transmission, neurotensin agonists may also inhibit 5-HT2A transmission, a pharmacological feature associated with atypical antipsychotic drugs. 相似文献
5.
The Role of APO-1-Mediated Apoptosis in the Immune System 总被引:12,自引:0,他引:12
6.
7.
Prolongation of graft survival in allogeneic islet transplantation by (−) 15-deoxyspergualin in the rat 总被引:1,自引:0,他引:1
P. K. Walter G. Dickneite H. U. Schorlemmer H. H. Sedlacek S. Jäger G. Feifel G. Seitz 《Diabetologia》1987,30(1):38-40
Summary The effect of 15-Deoxyspergualin, a novel drug which has been described to have anti-tumour activity, on allogeneic graft survival (Dark Agouti Lewis rats) after pancreatic islet transplantation was tested. A marked prolongation of graft survival could be shown using doses of 1.0, 2.5 and 5.0mg Deoxyspergualin/kg on day 0 until day +9 post transplantation. A maximum of 55.6 days (average) survival time was observed using 2.5mg/kg Deoxyspergualin compared to 5.2±0.6 days without immunosuppression. Using the chemiluminescence reaction of recipient monocytes after islet transplantation, a marked suppression of the monocyte system exceeding the treatment period could be observed. Since, in contrast to cyclosporin, B-cell toxicity could not be shown, the new drug seems to be a hopeful step towards successful allogeneic islet transplantation for treatment of diabetes. 相似文献
8.
Kirstin Vach Ali Al-Ahmad Annette Anderson Johan Peter Woelber Lamprini Karygianni Annette Wittmer Elmar Hellwig 《Nutrients》2021,13(3)
Background: Investigating the influence of nutrition on oral health has a long scientific history. Due to recent technical advances like sequencing techniques for the oral microbiota, this topic has gained scientific interest again. A basic challenge is to understand the influence of nutrition on the oral microbiota and on the interaction between the oral bacteria, which is also statistically challenging. Methods: Log-transformed ratios of two bacteria concentrations are introduced as the basic analytic tool. The framework is illustrated by application in an experimental study exposing eleven participants to different nutrition schemes in five consecutive phases. Results: The method could be sufficiently used to analyse the interrelation between the bacteria and to identify some bacterial groups with the same as well as different reactions to additional dietary components. It was found that the strongest changes in bacterial concentrations were achieved by the additional consumption of dairy products. Conclusion: A log ratio-based analysis offers insights into the relation of different bacteria while taking specific features of compositional data into account. The presented methods allow becoming independent of the behaviour of other bacteria, which is a disadvantage of common analysis methods of compositions. The results indicate that modulations of the oral biofilm microbiota due to nutrition change can be attained. 相似文献
9.
Clephane Kirstin Sartin-Tarm Anneliis Lorenz Tierney K. 《Archives of sexual behavior》2022,51(2):737-742
Archives of Sexual Behavior - 相似文献
10.