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Jose S. Pulido Ikuko Sugaya Jordan Comstock Kiminobu Sugaya 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2007,245(6):889-893
Purpose Reelin is important in the guidance of neuronal stem cells in the central nervous system during normal development. We wished
to determine whether reelin is expressed in the retina and cornea after injury.
Methods Mice underwent laceration of their retina as well as corneal epithelial debridement. The mice were sacrificed at 3 days, and
eyes were fixed and stained for reelin expression and reelin messenger ribonucleic acid (mRNA).
Results In normal eyes, reelin was expressed only at very low levels in the ganglion cell layer of the retina and the endothelial
cell layer of the cornea. In injured eyes, there was marked expression in reelin immunoreactivity in the retina and cornea.
Reelin gene expression was seen in the retina and cornea.
Conclusions Reelin is expressed during normal retinogenesis. This study shows that reelin is also upregulated following injury to the
retina and cornea. The expression of reelin following injury suggests that reelin may play an important role in regulating
stem cell trafficking in neuronal and nonneuronal tissues following injury similar to its role in normal organogenesis.
For consideration of publication in Graefe’s Archive for Clinical and Experimental Ophthalmology. 相似文献
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Takehisa Akiyama M.D. Nobutaka Osawa M.D. Kaoru Shimanuki M.D. Kimio Yashiro M.D Tadashi Oyake Ph.D. 《Pediatrics international》1991,33(1):20-26
As a model system for mucocutaneous lymph node syndrome (MCLS), we have advocated and used mice which had been rendered tolerant to Streptococcus pyogenes-associated antigens by neonatal infection with group A fteta-hemolytic streptococci, because these mice have shown a variety of peculiar bioimmunological characteristics bearing a striking resemblance to those of MCLS patients. The results of our current investigations reaffirmed the reliability of the animal model by indicating that mice subjected to neonatal infection with 5. pyogenes , or inoculation with streptococcal pyrogenic exotoxin (SPE) in Freund's adjuvant, were perfect counterparts of patients with MCLS on account of their platelet activation and hyperaggregability in response to provocative treatment, which are familiar findings in this disease. 相似文献
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Yoichi Kushima Tomonori Fujiwara Masumi Sanada Kimio Akagawa 《Journal of molecular neuroscience : MN》1997,8(1):19-27
We raised polyclonal and monoclonal antibodies against rat recombinant HPC-1/syntaxin 1A lacking a transmembrane domain. The
polyclonal antibody recognized two major bands at 35 and 40 kDa from rat brain membranes. A hybridoma clone designated 14D8,
however, recognized only one band at 35 kDa. A polyclonal antibody detected recombinant syntaxin 1B, as well as HPC-1/syntaxin
1A on an immunoblot, whereas 14D8 recognized recombinant HPC-1/syntaxin 1A, but not syntaxin 1B. Therefore, 14D8 is specific
for HPC-1/syntaxin 1A. Using this monoclonal antibody, we investigated the expression of HPC-1/syntaxin 1A in the rat hippocampal
membranes.
HPC-1/syntaxin 1A was present even in the embryonic d 19 (E19) hippocampal membranes, and it increased during the next two
postnatal wk. Pyramidal cell axons were intensely stained with the 14D8 monoclonal antibody, suggesting that HPC-1/syntaxin
1A was not restricted to the presynaptic terminal. Furthermore, we investigated the phosphorylation of HPC-1/syntaxin 1A in
the rat brain membranes. HPC-1/syntaxin 1A affinity-purified on a 14D8 IgG-coupled column was recognized by antiphophoserine
antibody, but not by antiphosphotyrosine and phosphothreonine antibodies. 相似文献
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K Sugaya T Kohama T Tsukada N Shimoda H Noto O Nishizawa T Harada S Tsuchida 《Hinyokika kiyo. Acta urologica Japonica》1991,37(5):485-489
Left renal veins of 77 patients were examined by computed tomography (CT) to evaluate its usefulness in determining the left renal vein compression which is causing renal bleeding. From CT image, left renal vein compression was observed in 6 (86%) of the 7 cases which had been classified as idiopathic renal bleeding, in 9 (21%) of the 42 cases which had urinary tract diseases causing hematuria, and in 3 (11%) of the 28 cases which did not have hematuria. In 15 of the 18 cases of left renal vein compression, left renal vein was compressed between the superior mesenteric artery and the abdominal aorta, showing so-called nutcracker phenomenon. In the remaining 3 cases, however, the superior mesenteric artery provided sharp delineation from the abdominal aorta. The superior mesenteric artery and the abdominal aorta made the mean angle of 35.5 degree in patients with normal left renal vein, the mean angle of 45.4 degrees in those with left renal vein compression without nutcracker phenomenon, and the mean angle of 11.9 degrees in those with nutcracker phenomenon. CT was superior to ultrasonography, in revealing left renal vein compression. 相似文献
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Satoshi Yoneda Yozo Kobayashi Takehiro Nunoi Kosuke Takeda Atsushi Matsumori Minoru Andoh Hirohisa Tsujinoue Kimio Nishimura Hiroshi Fukui 《Nihon Shokakibyo Gakkai zasshi》2006,103(11):1270-1273
A 23-year-old woman had lower abdominal pain, diarrhea and bloody stool was admitted and given a diagnosis of influenza B. Her home doctor had started treatment by neuraminidase inhibitor (oseltamivir) the previous day. Colonoscopic examination revealed an area of hemorrhage and erosion in the left transverse colon. After halting oseltamivir treatment these symptoms disappeared and her colonoscopic findings improved. A drug-induced lymphocyte stimulation test was positive for oseltamivir. This case is the first reported case of acute hemorrhagic colitis induced by oseltamivir. 相似文献