全文获取类型
收费全文 | 847篇 |
免费 | 43篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 32篇 |
妇产科学 | 4篇 |
基础医学 | 155篇 |
口腔科学 | 29篇 |
临床医学 | 61篇 |
内科学 | 224篇 |
皮肤病学 | 21篇 |
神经病学 | 72篇 |
特种医学 | 23篇 |
外科学 | 90篇 |
综合类 | 2篇 |
预防医学 | 10篇 |
眼科学 | 11篇 |
药学 | 76篇 |
肿瘤学 | 87篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 10篇 |
2020年 | 6篇 |
2019年 | 10篇 |
2018年 | 14篇 |
2017年 | 13篇 |
2016年 | 13篇 |
2015年 | 19篇 |
2014年 | 16篇 |
2013年 | 37篇 |
2012年 | 36篇 |
2011年 | 52篇 |
2010年 | 35篇 |
2009年 | 20篇 |
2008年 | 50篇 |
2007年 | 69篇 |
2006年 | 66篇 |
2005年 | 63篇 |
2004年 | 52篇 |
2003年 | 43篇 |
2002年 | 59篇 |
2001年 | 10篇 |
2000年 | 12篇 |
1999年 | 13篇 |
1998年 | 21篇 |
1997年 | 10篇 |
1996年 | 13篇 |
1995年 | 8篇 |
1994年 | 7篇 |
1993年 | 9篇 |
1992年 | 11篇 |
1991年 | 16篇 |
1990年 | 5篇 |
1989年 | 5篇 |
1988年 | 7篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 8篇 |
1983年 | 3篇 |
1982年 | 9篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1978年 | 4篇 |
1975年 | 4篇 |
1974年 | 2篇 |
1973年 | 3篇 |
1971年 | 5篇 |
1966年 | 3篇 |
1964年 | 1篇 |
排序方式: 共有899条查询结果,搜索用时 31 毫秒
1.
Diagnosis and treatment of thoracic outlet syndrome 总被引:2,自引:0,他引:2
Masataka Abe Tadashi Shimamura Jun Nishida Katsuaki Ichinohe 《Journal of orthopaedic science》1997,2(2):119-127
Patients who develop symptoms of thoracic outlet syndrome (TOS) have a predisposing anatomic abnormality. In most patients
with TOS, the symptoms are caused by entrapment of the brachial plexus and they do not arise from compression of the subclavian
artery, as was previously thought. The tests advocated for diagnosing this common syndrome (i.e., evaluating the positional
compression of the artery when the arms are raised, the neck is turned, or the shoulders are braced) cannot accurately diagnose
this syndrome. There are two reasons for this. The symptoms of TOS are not related to the compression of the artery in the
outlet in 98% of patients, and 75% of normal individuals without symptoms show diminished radial pulse on various provocation
tests. We employed four timed provocation tests (minute tests) to diagnose TOS: the timed Morley test, timed Wright test,
timed Eden test, and elevated arm stress exercise, all of which are very sensitive. In normal individuals without symptoms,
20% experience transitional symptoms such as slight pain and tiredness, on these tests indicating a subclinical state. TOS
is treated by keeping the thoracic outlet wide, this being done either conservatively or surgically. In 1993 and 1994, we
conservatively treated 418 of 422 patients with TOS by means of active exercise, a brace, and by block therapy. These measures
did not reduce the symptoms in 23 of these patients, so surgical treatment was indicated. In the remaining 4 of the 422 patients,
conservative treatment was not indicated and surgery was performed directly. All the patients showed significant clinical
improvement of varying degree.
Presented at the 69th Annual Meeting of the Japanese Orthopaedic Association, Tokyo, April 12, 1996 相似文献
2.
Shigeru Onodera Koji Saito Takafumi Saito Hitoshi Togashi Sumio Kawata Katsuaki Ukai Haruhide Shinzawa 《Nihon Shokakibyo Gakkai zasshi》2007,104(2):213-218
It is well known that long-term infection with Clonorchis sinensis often causes bile duct cancer, usually. It occurs in the intrahepatic bile duct. We encountered a rare case of clonorchiasis complicated with duodenal papillary cancer. The patient was a woman from China. Although clonorchiasis is rarely found in Japan, the promotion of international exchange may increase the number of visitors from endemic areas. Thus we must pay sufficient attention to this disease. Also, we reported that the microplate ELISA technique was useful in the diagnosis of clonorchiasis with high accuracy in this case. 相似文献
3.
Y Watanabe H Kanayama K Kato T Kanbe H Matsui S Mitani M Yoshino Y Nishiyama M Kanzaki 《Nihon Kyōbu Shikkan Gakkai zasshi》1991,29(10):1311-1316
A 56-year-old man was admitted to our hospital with right chest pain. Chest X-ray, CT scan and MRI revealed a chest wall tumor and enlarged mediastinal lymph nodes. Percutaneous lung biopsy was performed, and the pathological diagnosis of pleomorphic rhabdomyosarcoma was obtained. The only significant abnormal laboratory finding was elevation of serum NSE (24.5 ng/ml). Although chemotherapy (VAC-ADM) and radiation therapy were performed, the patient died about 7 months after admission. To our knowledge, only 17 cases of chest wall rhabdomyosarcoma have been reported in Japan. 相似文献
4.
5.
6.
The effects of intraperitoneal
and
methyl ester, specific inhibitors of nitric oxide (NO) synthase, were examined on the pentylenetetrazol (PTZ)-induced seizures in rats. The incidence and latency for the onset of myoclonic jerks, clonic seizures, and tonic generalized extension were observed as specific parameters among PTZ-induced seizures. Both drugs preferentially suppressed the tonic generalized extension and prolonged the latency for the onset of each parameter, suggesting NO has a significant effect on the PTZ-induced seizure. 相似文献
7.
8.
Evidence for adhesin activity in the acid-stable moiety of the phosphomannoprotein cell wall complex of Candida albicans. 总被引:2,自引:7,他引:2 下载免费PDF全文
Previously, we showed that Candida albicans hydrophilic yeast cells adhere specifically to mouse splenic marginal-zone macrophages. The adhesins are part of the yeast cell wall phosphomannoprotein complex, and one adhesin site, which reacts with the monoclonal antibody 10G, was identified as a beta-1,2-linked tetramannose in the acid-labile portion of the complex. We report here that the acid-stable part of the complex, which has not been reported previously to have adhesin activity, is in large part responsible for yeast cell binding to the splenic marginal zone. The phosphomannoprotein complex, termed Fr.II, was isolated from C. albicans serotype B yeast cells by beta-mercaptoethanol extraction and concanavalin A-agarose affinity chromatography. Fr.II is devoid of the serotype A-specific antigen factor 6, which functions in yeast cell attachment to epithelial cells. The acid-stable part of Fr.II (i.e., Fr.IIS) was obtained by mild acid hydrolysis and size exclusion fractionation. Fr.IIS was further fractionated into four fractions, Fr.IIS1, Fr.IIS2, Fr.IIS3, and Fr.IIS4, by concanavalin A-agarose column chromatography and elution with a linear gradient of alpha-methyl-D-mannopyranoside. Adhesin activity of these fractions was determined by their ability to block yeast cell binding to the splenic marginal zone. Fr.IIS1 and Fr.IIS2 yielded more material and stronger adhesin activity than either Fr.IIS3 or Fr.IIS4. Only Fr.IIS1 did not react with antibodies (anti-factor 5 and monoclonal antibody 10G) specific for the acid-labile beta-1,2-linked oligosaccharides. Fr.IIS1-coated latex beads attached specifically to the marginal zone in a pattern identical to that of yeast cell binding. Furthermore, Fr.IIS1-latex bead attachment was inhibited by soluble Fr.II or Fr.IIS. Initial chemical analyses indicate that the adhesin site on Fr.IIS1 is a carbohydrate because adhesin activity was destroyed by periodate oxidation but not by proteinase K digestion. 相似文献
9.
Effect of rectal administration of rebamipide on dextran sulfate sodium-induced colitis: Role of hepatocyte growth factor 总被引:1,自引:0,他引:1
R. Murai T. Kanbe T. Mukoyama T. Shimomura K. Hashiguchi Y. Yoshida H. Tsuchiya Y. Hoshikawa A. Kurimasa G. Shiota 《Inflammation research》2007,56(6):240-245
Objective and design: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth
factor (HGF) in the action of rebamipide.
Materials: Fifty-five and forty female Balb/c mice, respectively, were used in Exp. 1 and 2.
Treatment: 50 mg/kg/day rebamipide (Exp. 1) and 1 × 107 pfu pAxCAHGF (the CAG promoter-driving HGF gene in adenovirus vector) (Exp. 2) were intrarectally introduced after induction
of colitis by 4 % dextran sulfate sodium (DSS).
Methods: Therapeutic effects were assessed by cell proliferation and apoptosis.
Results: Rebamipide caused proliferation of epithelial cells at 10 days after treatment, and decreased apoptosis at 10, 14 and 21 days,
compared with controls. Expression of HGF was greatly increased in rebamipide-treated mice. pAxCAHGF caused cell proliferation
and apoptosis, which showed the same pattern as with rebamipide treatment.
Conclusions: Rectal administration of rebamipide is effective for DSS-induced colitis in association with induction of HGF.
Received 17 June 2006; returned for revision 23 August 2006; returned for final revision 29 October 2006; accepted by I. Ahnfelt-R?nne
14 December 2006 相似文献
10.
Katsuaki Ito Erika Shimomura Takahiro Iwanaga Mitsuya Shiraishi Kazutoshi Shindo Junji Nakamura Hiromitsu Nagumo Minoru Seto Yasuharu Sasaki† Yoh Takuwa‡ 《The Journal of physiology》2003,546(3):823-836
Although the prostate gland is a rich source of α1-adreno- (α1-AR) and m1-cholino receptors (m1-AChR), the membrane processes associated with their activation in glandular epithelial cells is poorly understood. We used the whole-cell patch-clamp technique to show that the agonists of the respective receptors, phenylephrine (PHE) and carbachol (CCh), activate cationic membrane currents in lymph node carcinoma of the prostate (LNCaP) human prostate cancer epithelial cells, which are not dependent on the filling status of intracellular IP3 -sensitive Ca2+ stores, but directly gated by diacylglycerol (DAG), as evidenced by the ability of its membrane permeable analogue, OAG, to mimic the effects of the agonists. The underlying cationic channels are characterized by the weak field-strength Eisenman IV permeability sequence for monovalent cations ( P K (25) > P Cs (4.6) > P Li (1.4) > P Na (1.0)), and the following permeability sequence for divalent cations: P Ca (1.0) > P Mg (0.74) > P Ba (0.6) > P Sr (0.36) > P Mn (0.3). They are 4.3 times more permeable to Ca2+ than Na+ and more sensitive to the inhibitor 2-APB than SK&F 96365. RT-PCR analysis shows that DAG-gated members of the transient receptor potential (TRP) channel family, including TRPC1 and TRPC3, are present in LNCaP cells. We conclude that, in prostate cancer epithelial cells, α1-ARs and m1-AChRs are functionally coupled to Ca2+ -permeable DAG-gated cationic channels, for which TRPC1 and TRPC3 are the most likely candidates. 相似文献