全文获取类型
收费全文 | 924篇 |
免费 | 68篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 49篇 |
妇产科学 | 31篇 |
基础医学 | 113篇 |
口腔科学 | 65篇 |
临床医学 | 77篇 |
内科学 | 172篇 |
皮肤病学 | 13篇 |
神经病学 | 66篇 |
特种医学 | 9篇 |
外科学 | 182篇 |
综合类 | 2篇 |
预防医学 | 92篇 |
眼科学 | 10篇 |
药学 | 39篇 |
中国医学 | 1篇 |
肿瘤学 | 70篇 |
出版年
2023年 | 18篇 |
2022年 | 15篇 |
2021年 | 47篇 |
2020年 | 34篇 |
2019年 | 40篇 |
2018年 | 38篇 |
2017年 | 24篇 |
2016年 | 29篇 |
2015年 | 43篇 |
2014年 | 47篇 |
2013年 | 47篇 |
2012年 | 61篇 |
2011年 | 61篇 |
2010年 | 35篇 |
2009年 | 25篇 |
2008年 | 39篇 |
2007年 | 39篇 |
2006年 | 40篇 |
2005年 | 31篇 |
2004年 | 39篇 |
2003年 | 31篇 |
2002年 | 21篇 |
2001年 | 14篇 |
2000年 | 9篇 |
1999年 | 14篇 |
1998年 | 8篇 |
1997年 | 3篇 |
1996年 | 5篇 |
1995年 | 3篇 |
1993年 | 2篇 |
1992年 | 11篇 |
1991年 | 4篇 |
1990年 | 8篇 |
1989年 | 12篇 |
1988年 | 7篇 |
1987年 | 6篇 |
1986年 | 14篇 |
1985年 | 14篇 |
1984年 | 4篇 |
1983年 | 7篇 |
1982年 | 4篇 |
1980年 | 4篇 |
1979年 | 7篇 |
1978年 | 2篇 |
1977年 | 6篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1969年 | 4篇 |
1965年 | 2篇 |
排序方式: 共有994条查询结果,搜索用时 31 毫秒
1.
2.
M. Iachina P.M. Ljungdalh R.G. Sørensen L. Kaerlev J. Blaakær O. Trosko N. Qvist B.M. Nørgård 《Clinical oncology (Royal College of Radiologists (Great Britain))》2019,31(2):115-123
Aims
To examine the influence of pre-existing psychiatric disorder on the choice of treatment in patients with gynaecological cancer.Materials and methods
The analyses were based on all patients who underwent surgical treatment for endometrial, ovarian or cervical cancer who were registered in the Danish Gynecological Cancer Database in the years 2007–2014 (3059 patients with ovarian cancer, 5100 patients with endometrial cancer and 1150 with cervical cancer). Logistic regression model and Cox regression model, adjusted for relevant confounders, were used to estimate the effect of pre-existing psychiatric disorder on the course of cancer treatment. Our outcomes were (i) presurgical oncological treatment, (ii) macroradical surgery for patients with ovarian cancer, (iii) radiation/chemotherapy within 30 days and 100 days after surgery and (iv) time from surgery to first oncological treatment.Results
In the group of patients with ovarian cancer, more patients with a psychiatric disorder received macroradical surgery versus patients without a psychiatric disorder, corresponding to an adjusted odds ratio of 1.24 (95% confidence interval 0.62–2.41) and the chance for having oncological treatment within 100 days was odds ratio = 1.26 (95% confidence interval 0.77–2.10). As for patients with endometrial cancer, all outcome estimates were close to unity. The adjusted odds ratio for oncological treatment within 30 days after surgery in patients with cervical cancer with a history of psychiatric disorder was 0.20 (95% confidence interval 0.03–1.54).Conclusions
We did not find any significant differences in the treatment of ovarian and endometrial cancer in patients with pre-existing psychiatric diagnoses. When it comes to oncological treatment, we suggest that increased attention should be paid to patients with cervical cancer having a pre-existing psychiatric diagnosis. 相似文献3.
4.
Gregers Mads Christian Tofte Mikkelsen Søren Lindvig Katrine Prier Brøchner Anne Craveiro 《Neurocritical care》2020,33(1):273-282
Neurocritical Care - For years, the use of ketamine as an anesthetic to patients suffering from acute brain injury has been debated because of its possible deleterious effects on the cerebral... 相似文献
5.
Abstract: This review examines the liver-damaging side effects of anabolic-androgenic steroids (AAS). It seems that AAS can cause development of peliosis hepatis, subcellular changes of hepatocytes, hepatocellular hyperplasia and hepatocellular adenomas. On the other hand, it has not been convincingly proved that AAS can cause development of hepatocellular carcinomas when used in the usual therapeutic doses. Tumours reported as hepatocellular carcinomas caused by AAS seem to be hyperplastic lesions of a benign nature able to regress with withdrawal of the putative agent. The effects of untraditional combinations and high-dose AAS are not yet known, leaving the possibility of a carcinogenic effect in those cases. 相似文献
6.
Borgen K Sørum M Wasteson Y Kruse H Oppegaard H 《Microbial drug resistance (Larchmont, N.Y.)》2002,8(4):363-368
Vancomycin-resistant enterococci (VRE) have frequently been isolated from Norwegian poultry production following the prohibition of the glycopeptide growth promoter avoparcin since 1995. In the present study, a close genetic linkage between the vanA and erm(B) determinants in an Enterococcus hirae isolate of poultry origin is demonstrated, a result that indicates a mechanism for co-selection and maintenance of vancomycin resistance in absence of selective pressure from avoparcin. A total of 36 vanA-positive enterococci of poultry origin, also phenotypically resistant to erythromycin and/or tetracycline, were analyzed by PCR for identification of erm and tet resistance determinants. An E. hirae isolate harbored erm(B) and tet(K), and in this isolate vanA and erm(B) were located on a BamHI fragment of an approximately 50-kb plasmid. Approximately 3 kb of this fragment was amplified by PCR with vanA and erm(B) primers. Sequence analysis of the region between erm(B) and vanZ of Tn1546 showed a truncated IS1216V inserted downstream of the erm(B) stop codon, aligned with a conserved copy of the 3'-inverted terminal repeat of Tn1546. Mating experiments with the E. hirae isolate as donor and E. faecalis JH2-2 as recipient did not result in any transconjugants, indicating that the vanA/erm(B)-carrying plasmid was nonconjugative under the given experimental conditions. 相似文献
7.
E. Dietrichs D. E. Haines H. Qvist 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1985,60(3):483-491
Summary Hypothalamic efferents to the lateral reticular nucleus (NRL) have been demonstrated in the cat by means of anterograde and retrograde axonal transport of the wheat germ agglutinin — horseradish peroxidase (WGA-HRP) complex. Pressure injections of the WGA-HRP complex into the hypothalamus resulted in anterograde labelling of branching terminal axons both in the NRL and in an adjacent area, presumably the ventrolateral catecholaminergic cell group (A1). After microiontophoretical ejections of the WGA-HRP complex into the NRL from a ventral approach, retrogradely labelled neurons were found in the lateral, dorsal, posterior and anterior hypothalamic areas and in the tubero-mammillary, dorsomedial and periventricular nuclei. The projection is bilateral with a clear ipsilateral predominance and has its main origin in the lateral hypothalamic area. The locations of hypothalamic cells projecting to the NRL are somewhat different from those giving rise to hypothalamo-cerebellar and hypothalamo-spinal connections. The present demonstration of a hypothalamic input to one of the major precerebellar relay nuclei introduces a new possible indirect route through which the cerebellum may be influenced by the hypothalamus. The different indirect and direct hypothalamo-cerebellar pathways and their potential functional importance are discussed. 相似文献
8.
9.
Ebbe Eldrup Simone Theilade Mette Lorenzen Christine H Andreassen Katrine H Poulsen John E Nielsen Ditte Hansen Daniel El Fassi Jais O Berg Per Bagi Anne Jørgensen Martin Blomberg Jensen 《Journal of bone and mineral research》2021,36(2):322-333
Intramuscular injections of paraffin oil can cause foreign body granuloma formation and hypercalcemia. Macrophages with the ability to produce high levels of 1,25(OH)2D3 may induce the mineral disturbance, but no major series of patients have been published to date. Here, medical history, physical evaluation, biochemical, and urinary analysis for calcium homeostasis were obtained from 88 males, who 6 years previously had injected paraffin or synthol oil into skeletal muscle. Moreover, granuloma tissue from three men was cultured for 48 hours ex vivo to determine 1,25(OH)2D3 production supported by qPCR and immunohistochemistry of vitamin D metabolism and immune cell populations after treatment with 14 different drugs. The 88 men were stratified into men with hypercalcemia (34%), whereas normocalcemic men were separated into men with either normal (42%) or suppressed parathyroid hormone (PTH) (24%). All men had high calcium excretion, and nephrolithiasis was found in 48% of hypercalcemic men, 22% of normocalcemic men with normal PTH, and 47% of normocalcemic men with suppressed PTH. Risk factors for developing hypercalcemia were oil volume injected, injection of heated oil, high serum interleukin-2 receptor levels, and high urine calcium. High 1,25(OH)2D3/25OHD ratio, calcium excretion, and low PTH was associated with nephrolithiasis. The vitamin D activating enzyme CYP27B1 was markedly expressed in granuloma tissue, and 1,25(OH)2D3 was released in concentrations corresponding to 40% to 50% of the production by human kidney specimens. Dexamethasone, ketoconazole, and ciclosporin significantly suppressed granulomatous production of 1,25(OH)2D3. In conclusion, this study shows that injection of large oil volumes alters calcium homeostasis and increases the risk of nephrolithiasis. Hypercalciuria is an early sign of disease, and high granulomatous 1,25(OH)2D3 production is part of the cause. Prospective clinical trials are needed to determine if ciclosporin, ketoconazole, or other drugs can be used as prednisolone-sparing treatment. © 2020 American Society for Bone and Mineral Research (ASBMR). 相似文献