全文获取类型
收费全文 | 65227篇 |
免费 | 5287篇 |
国内免费 | 1965篇 |
专业分类
耳鼻咽喉 | 615篇 |
儿科学 | 1770篇 |
妇产科学 | 1321篇 |
基础医学 | 7965篇 |
口腔科学 | 940篇 |
临床医学 | 10048篇 |
内科学 | 11012篇 |
皮肤病学 | 645篇 |
神经病学 | 5280篇 |
特种医学 | 1708篇 |
外国民族医学 | 22篇 |
外科学 | 6249篇 |
综合类 | 4482篇 |
现状与发展 | 5篇 |
一般理论 | 50篇 |
预防医学 | 7484篇 |
眼科学 | 1049篇 |
药学 | 5095篇 |
23篇 | |
中国医学 | 1453篇 |
肿瘤学 | 5263篇 |
出版年
2024年 | 136篇 |
2023年 | 820篇 |
2022年 | 1608篇 |
2021年 | 2349篇 |
2020年 | 1715篇 |
2019年 | 1905篇 |
2018年 | 2101篇 |
2017年 | 1751篇 |
2016年 | 1681篇 |
2015年 | 2203篇 |
2014年 | 2811篇 |
2013年 | 3443篇 |
2012年 | 5005篇 |
2011年 | 5383篇 |
2010年 | 2959篇 |
2009年 | 2532篇 |
2008年 | 4145篇 |
2007年 | 4060篇 |
2006年 | 4013篇 |
2005年 | 3960篇 |
2004年 | 3366篇 |
2003年 | 2910篇 |
2002年 | 2804篇 |
2001年 | 791篇 |
2000年 | 802篇 |
1999年 | 964篇 |
1998年 | 846篇 |
1997年 | 739篇 |
1996年 | 567篇 |
1995年 | 482篇 |
1994年 | 413篇 |
1993年 | 364篇 |
1992年 | 352篇 |
1991年 | 294篇 |
1990年 | 245篇 |
1989年 | 252篇 |
1988年 | 222篇 |
1987年 | 200篇 |
1986年 | 191篇 |
1985年 | 180篇 |
1984年 | 144篇 |
1983年 | 109篇 |
1982年 | 110篇 |
1981年 | 117篇 |
1980年 | 86篇 |
1979年 | 59篇 |
1978年 | 43篇 |
1977年 | 44篇 |
1976年 | 28篇 |
1975年 | 30篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Karl Johnson Katherine W. Saylor Isabella Guynn Karen Hicklin Jonathan S. Berg Kristen Hassmiller Lich 《Genetics in medicine》2022,24(2):262-288
PurposeUnderstanding the value of genetic screening and testing for monogenic disorders requires high-quality, methodologically robust economic evaluations. This systematic review sought to assess the methodological quality among such studies and examined opportunities for improvement.MethodsWe searched PubMed, Cochrane, Embase, and Web of Science for economic evaluations of genetic screening/testing (2013-2019). Methodological rigor and adherence to best practices were systematically assessed using the British Medical Journal checklist.ResultsAcross the 47 identified studies, there were substantial variations in modeling approaches, reporting detail, and sophistication. Models ranged from simple decision trees to individual-level microsimulations that compared between 2 and >20 alternative interventions. Many studies failed to report sufficient detail to enable replication or did not justify modeling assumptions, especially for costing methods and utility values. Meta-analyses, systematic reviews, or calibration were rarely used to derive parameter estimates. Nearly all studies conducted some sensitivity analysis, and more sophisticated studies implemented probabilistic sensitivity/uncertainty analysis, threshold analysis, and value of information analysis.ConclusionWe describe a heterogeneous body of work and present recommendations and exemplar studies across the methodological domains of (1) perspective, scope, and parameter selection; (2) use of uncertainty/sensitivity analyses; and (3) reporting transparency for improvement in the economic evaluation of genetic screening/testing. 相似文献
2.
Karen Kayser Ariel Washington Lesley M. Harris Barbara Head 《Journal of psychosocial oncology》2021,39(1):17-34
Abstract
Purpose
Financial hardship can be a major cause of distress among persons with cancer, resulting in chronic stress and impacting physical and emotional health. This paper provides an analysis of the lived experience of cancer patients’ financial hardship from diagnosis to post-treatment. 相似文献3.
Qiangsheng He Chongfei Huang Xiwen Qin Yuanyuan Yu Di Tang Junjie Huang Zi Chong Kuo Yuyao Ling Deli Mao Bin Xia Wenjing Li Kuiqing Lu Man Yang Yulong He Wenbo Meng Jinqiu Yuan Yihang Pan 《International journal of cancer. Journal international du cancer》2023,153(5):942-949
Recent epidemiological studies suggested that proton pump inhibitor (PPI) use was associated with an increased risk of biliary tract cancer (BTC), however, confounders were not adequately controlled. Our study aimed to evaluate PPI use and subsequent risk of BTC and its subtypes in three well-established cohorts. We conducted a pooled analysis of the subjects free of cancers in UK Biobank (n = 463 643), Nurses' Health Study (NHS, n = 80 235) and NHS II (n = 95 869). Propensity score weighted Cox models were used to estimate marginal HRs of PPIs use on BTC risk, accounting for potential confounders. We documented 284 BTC cases in UK Biobank (median follow-up: 7.6 years), and 91 cases in NHS and NHS II cohorts (median follow-up: 15.8 years). In UK biobank, PPI users had a 96% higher risk of BTC compared to nonusers in crude model (HR 1.96, 95% CI 1.44-2.66), but the effect was attenuated to null after adjusting for potential confounders (HR 0.95, 95% CI 0.60-1.49). PPI use was not associated with risk of BTC in the pooled analysis of three cohorts (HR 0.93, 95% CI 0.60-1.43). We also observed no associations between PPI use with risk of intrahepatic (HR 1.00, 95% CI 0.49-2.04), extrahepatic bile duct (HR 1.09, 95% CI 0.52-2.27) and gallbladder cancers (HR 0.66, 95% CI 0.26-1.66) in UK Biobank. In summary, regular use of PPIs was not associated with the risk of BTC and its subtypes. 相似文献
4.
5.
6.
7.
8.
9.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献