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排序方式: 共有127条查询结果,搜索用时 15 毫秒
1.
Katsuo Kamata Ayako Makino Noriyasu Kanie Shu-ichi Oda Takayuki Matsumoto Tsuneo Kobayashi Toyohiko Kikuchi Masato Nishimura Toshio Honda 《Journal of Smooth Muscle Research》2006,42(2-3):75-88
Anthocyanins, which are responsible for a variety of bright colors (including red, blue, and purple) in fruits, vegetables, and flowers, are consumed as dietary polyphenols. Anthocyanin-containing fruits are thought to decrease coronary heart disease and are used in anti-diabetic preparations. Diabetes is associated with a variety of cardiovascular complications that may be mediated by endothelial dysfunction, and so this study was designed mainly to characterize the influence of a synthesized anthocyanidin derivative (HK-008) over acetylcholine (ACh)-induced relaxation in mesenteric arterial beds isolated from rats. In a glucose-tolerance test in intact rats, HK-008 (30 mg/kg) reduced the glucose level as effectively as the same dose of glibenclamide. The aortic relaxation induced by pinacidil (an ATP-sensitive potassium channel opener) was greatly inhibited by glibenclamide (10 microM), and also significantly inhibited by HK-008 (10 microM). Interestingly, the ACh-induced relaxation in the perfused, preconstricted mesenteric arterial bed was significantly enhanced by HK-008 (10 microM), and this enhancement was significantly attenuated by indomethacin (10 microM). The ACh-induced mesenteric relaxation was impaired by an increase in oxidative stress, viz. superoxide-generating treatment [xanthine oxidase (XO; 0.1 U/ml) plus hypoxanthine (HX; 10 microM)]. However, this impairment was strongly suppressed by HK-008 (10 microM). These results suggest that HK-008 increases endothelium-induced relaxation by suppressing oxidative stress or modulating prostanoids signaling. This compound may therefore be useful against certain cardiovascular disorders. 相似文献
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3.
Su Ma Seiji Kurihara Yasuhiro Tomimori Sunnam Kim Eunsang Kwon Atsushi Muramatsu Kiyoshi Kanie 《RSC advances》2020,10(54):32984
Vesicles or micelles prepared from amphiphiles with azobenzene (Az) moieties and long alkyl chains have attracted much attention in drug delivery systems. To induce release behavior from smart carriers via trans–cis photoisomerization of the Az groups, UV light exposure is typically used, but it can damage DNA and hardly penetrates cells. In this paper, Az-containing phospholipids without long alkyl tails were designed and synthesized; in these compounds, the end group of the Az moiety was substituted with a –NO2 and –OCH3 group (abbreviated N6 and M6, respectively). N6 self-assembled into H-aggregates with an interdigitated bilayered structure in water through the antiparallel orientation due to π–π interactions of the Az group, the attractive van der Waals forces, and the interactions and bending behavior of the phosphocholine groups. Vesicles showing visible light stimuli-responsive behavior were obtained by mixing N6 and M6, and the release of encapsulated calcein was triggered by visible light.A mixture of a nitro- and methoxy-substituted azo-containing phospholipids without long alkyl tails formed vesicles showing visible light stimuli-responsive behavior. Release of encapsulated calcein from the vesicles was triggered by visible light. 相似文献
4.
Takahito Kanie Akihiko Kadokawa Mutsumi Nagata Hiroyuki Arikawa 《Journal of prosthodontic research》2013,57(1):46-50
PurposeThe stress relaxation and compressive strength of resin, resin-modified glass ionomer, glass ionomer, polycarboxylate, and zinc oxide eugenol cements were measured to determine the characteristics of these materials after setting.MethodsA total of 19 luting cements including 12 permanent cements and 7 temporary cements were used. Cylindrical cement specimens (10 mm long and 6 mm in diameter) were obtained by chemical setting or light curing. The specimens were stored for 24–36 h in water at 37 °C and were then used for the stress relaxation and compression tests. The stress relaxation test was carried out using three constant cross-head speeds of 5, 50, and 100 mm/min. Upon reaching the preset dislocation of 0.5 mm, the cross-head movement was stopped, and the load was recorded for 60 s. Fractional stress loss at 1 s was calculated from the relaxation curves. The compressive strength and modulus were measured at a cross-head speed of 1 mm/min. Data were analyzed with the Kruskal–Wallis test and Holm's test.ResultsA zinc oxide eugenol cement [TempBOND NX] exhibited the largest fractional stress loss. A resin cement [ResiCem] showed the largest compressive strength, while a glass ionomer cement [HY-BOND GLASIONOMER CX] showed the largest compressive modulus among all tested cements (p < 0.05).ConclusionThe fractional stress loss could not be classified by the cement type. Two implant cements [Multilink Implant and IP Temp Cement] showed similar properties with permanent resin cements and temporary glass ionomer cements, respectively. Careful consideration of the choice of cement is necessary. 相似文献
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Congenital radio-ulnar synostosis 总被引:1,自引:0,他引:1
Thirty-three patients with congenital radio-ulnar synostosis were examined. There was one familial predisposition. Chromosomal patterns were examined in seventeen patients and were normal. Bone maturation appeared normal. The radial deviation angle, in the patients whose distal radial epiphysis had closed, was elevated (Madelung's deformity). However, in the patients whose distal epiphysis maturation score was 8, it was not elevated. On the other hand, elongation of the ulna (plus variant) and/or dorsal dislocation of the distal end of the ulna was seen in early life. In terms of treatment, all attempts to divide the two bones failed. It was found that derotation of the nonwriting hand by an osteotomy through the proximal fusion mass was a useful procedure. 相似文献
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8.
Kamata K Kanie N Matsumoto T Kobayashi T 《Journal of cardiovascular pharmacology》2004,44(Z1):S186-S190
An accumulating body of evidence indicates that an increased endothelin-1 level is related to endothelial dysfunction in cardiovascular diseases. In this study, we tested whether prolonged treatment of aortas with endothelin-1 induces endothelial dysfunction. When isolated aortas from control rats were cultured with endothelin-1, at levels above the plasma concentration, the acetylcholine-induced endothelium-dependent relaxation was significantly decreased (as compared with endothelin-1-nontreatment). This endothelin-1-induced endothelial dysfunction was more marked in aortas obtained from rats with streptozotocin-induced diabetes than in those from the controls. The endothelin-1- induced attenuation was very strongly suppressed by co-incubation with J-104132, endothelin receptor A/B antagonist, or polyethylene-glycolated superoxide dismutase, a cell-permeant superoxide anion scavenger or LY294002, phosphoinositide 3-kinase inhibitor. These results indicate that endothelin-1 can induce endothelial dysfunction, and that this may be related to superoxide generation and to PI3-kinase activity. 相似文献
9.
This study examined the reinforcing effect of woven glass fibers on the relaxation modulus by three-point loading of denture base resin. Three sandwich-type flexure test specimens polymerized by heating were used, all 3 mm thick: glass fibers in compression (U type); glass fibers in the center (C type); and glass fibers in tension (L type). Unreinforced specimens (ACR) were produced as a control. The relaxation modulus after 8 sec from the start of stress (Er(8)) was calculated from stress relaxation curves. In the glassy state, the Er(8)s of the U and L types were greater than those of the ACR and C types. In the rubbery state (plateau region), the Er(8)s of the U and L types were greater than those of the ACR and C types. The woven glass fibers added to the U and L type specimens increased the relaxation modulus of PMMA near the oral temperature; moreover, they inhibited stress relaxation when the temperature increased. 相似文献
10.
The light-attenuating effects of enamel on the mechanical properties of light-cured composite resins were evaluated using simple experimental filters. Three filters were designed to simulate the light transmittance characteristics of 0.5, 1.0, and 1.5 mm thick human enamel. The Knoop hardness numbers (KHN) and the elastic modulus in transverse tests for twelve shades of three light-cured composite resins were examined. These resins were cured either using direct irradiation with a light source, or indirect irradiation through one of the filters. The attenuations of light by 0.5, 1.0, and 1.5 mm thick enamel filter were 45%, 67% and 81% in the 430 nm-550 nm wavelength region, respectively. For all materials, KHN and the elastic modulus of specimens irradiated through filters were significantly lower than those irradiated directly. The results suggest that the light-attenuating effect of enamel reduces the mechanical properties of light-cured resin, and may cause poor clinical longevity of restorations. 相似文献