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1.
Kazuhiko Kyoshima Susumu Oikawa Miki Kanaji Hideo Zenisaka Takeomi Takizawa Tetsuya Goto Hisayoshi Takasawa Atsushi Watanabe Kazuo Tokushige Keiichi Sakai 《Journal of clinical neuroscience》2003,10(5):571-578
Some chordomas have a very poor prognosis because of their aggressive growth nature, but the efficacy of repeat operations for these cases has not been well documented. This report concerns 3 patients with aggressive chordoma of the clivus, who underwent operations 6 to 12 times over a period of 8 to 17 years because of symptomatic regrowth. Overall mean interval between repeat operations was 18 months with a range from 5 to 57 months and survival times were 9 to19 years after the first surgery. Main symptoms before each operation were diplopia and visual disturbance. Repeat palliative operations by intentional extradural debulking of the tumour to decompress offending neural structures, as well as maximal removal of the tumour, using appropriate skull base approaches, can mitigate progressive symptoms, and may result in better quality and some prolongation of life, although our patients gradually deteriorated neurologically throughout the clinical course. 相似文献
2.
Tanaka G Kanaji S Hirano A Arima K Shinagawa A Goda C Yasunaga S Ikizawa K Yanagihara Y Kubo M Kuriyama-Fujii Y Sugita Y Inokuchi A Izuhara K 《International immunology》2005,17(6):797-805
It is widely known that IL-4 and IL-13 act on various kinds of cells, including B cells, resulting in enhancement of proliferation, class switching to IgE and expression of several surface proteins. These functions are important for the recognition of the various antigens in B cells and are known to be involved in the pathogenesis of allergic diseases. However, it has not been known whether IL-4/IL-13 is involved in the metabolism of various kinds of xenobiotics including 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD), and it remains undetermined whether TCDD, an environmental pollutant, influences IgE production in B cells, exaggerating allergic reactions. We identified IL-4- or IL-13-inducible genes in a human Burkitt lymphoma cell line, DND-39, using microarray technology, in which the AHR gene was included. The AHR gene product, the aryl hydrocarbon receptor (AhR), was induced by IL-4 in both mouse and human B cells in a STAT6-dependent manner. IL-4 alone had the ability to translocate the induced AhR to the nuclei. TCDD, a ligand for AhR, rapidly degraded the induced AhR by the proteasomal pathway, although IL-4-activated AhR sustained its expression. AhR activated by IL-4 caused expression of a xenobiotic-metabolizing gene, CYP1A1, and TCDD synergistically acted on the induction of this gene by IL-4. However, the induction of AhR had no effect on IgE synthesis or CD23 expression. These results indicate that the metabolism of xenobiotics would be a novel biological function of IL-4 and IL-13 in B cells, whereas TCDD is not involved in IgE synthesis in B cells. 相似文献
3.
Takao Obara MD Yoshihide Fujimoto Reiko Tanaka Yukio Ito Takaya Kodama Tohru Yashiro Yoshiharu Kanaji Tomoyuki Yamashita Atsushi Fukuuchi 《Surgery today》1990,20(4):481-486
Although hyperfunctioning mediastinal parathyroid lesions that require median sternotomy or thoracotomy for removal are occasionally
present, the majority are located in the anterior mediastinum closely associated with the thymus. Only eight cases of ectopic
hyperfunctioning parathyroid tumors in the middle mediastinum have been reported. We experienced two cases of either persistent
or recurrent hyperparathyroidism in which abnormal parathyroid tissue was located in the aorticopulmonary window. One of the
patients had a parathyroid adenoma and the other had metastatic lesions of parathyroid carcinoma. In both cases, thallium
scanning proved useful in identifying the lesions while computed tomography scan was effective for mediastinal three-dimensional
localization. In one case, single photon emission computed tomography imaging with thallium proved beneficial for both identification
and localization of the middle mediastinal lesion. The surgical approach used in both cases was different. In one case, left
thoracotomy was performed, after which the ligamentum arteriosum was divided, and an adenoma anterior to the left main bronchus
and posterior to the left pulmonary artery removed. In the other case, two metastatic tumors of parathyroid carcinoma anterior
to the right main bronchus and posterior to the right pulmonary artery were resected through a median sternotomy and opening
of the pericardium. 相似文献
4.
Kanaji N Bandoh S Takano K Kadota K Haba R Matsunaga T Kohno K Kushida Y Yamamoto Y Ishida T 《The American journal of the medical sciences》2008,335(4):310-314
Squalene is a type of oil obtained from shark liver. We describe a 76-year-old man diagnosed with chronic exogenous lipoid pneumonia due to squalene. A chest CT scan revealed pulmonary consolidation with ground-glass opacities in the right upper lobe. Positron emission tomography (PET) revealed significant uptake of 2-deoxy-2-F-fluoro-d-glucose (FDG) and 3'-deoxy-3'-F-fluorothymidine (FLT). Bronchoalveolar lavage (BAL) fluid contained many lipid-laden macrophages, and a transbronchial lung biopsy specimen showed clusters of foamy macrophages in alveolar spaces and granulomatous lesions. In addition, the presence of squalene in the BAL fluid was confirmed by gas chromatography-mass spectrometry, leading to a diagnosis of squalene-induced lipoid pneumonia. To the best of our knowledge, this is the first report of squalene-induced lipoid pneumonia in which squalene itself was successfully detected. This case also suggests the possibility that lipoid pneumonia shows significant uptake in FDG-PET and FLT-PET. 相似文献
5.
von Willebrand factor propeptide to antigen ratio identifies platelet activation and reduced von Willebrand factor survival phenotype in mice
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P. M. Jacobi S. Kanaji D. Jakab A. L. Gehrand J. M. Johnsen S. L. Haberichter 《Journal of thrombosis and haemostasis》2018,16(3):546-554
Essentials
- Reduced survival of von Willebrand factor (VWF) in plasma causes type 1C von Willebrand disease.
- Blood was collected from mouse strains by various methods and VWF propeptide and antigen assayed.
- VWF propeptide to antigen ratio identifies a reduced VWF survival phenotype in mice.
- This ratio validates the acceptability of murine blood samples for coagulation studies.
Summary
Background
Reduced plasma survival of von Willebrand factor (VWF) is characteristic of patients with type 1C von Willebrand disease (VWD). These subjects can be identified by an increased steady‐state ratio of plasma VWF propeptide (VWFpp) to VWF antigen (VWF:Ag). A similar phenotype occurs in mice with the Mvwf1 allele.Objectives
To (i) determine if the VWFpp/VWF:Ag ratio can be used to identify a ‘type 1C’ phenotype in mice, (ii) determine the most reliable method for murine blood sampling, and (iii) identify the source of VWF released during problematic blood collection.Methods
‘Platelet‐VWF’ and ‘endothelial‐VWF’ mice were generated by bone marrow transplantation between C57BL/6J and VWF‐/‐ mice. Several blood sampling methods were used and murine VWFpp and VWF:Ag levels determined. Plasma and platelet VWF:Ag and VWFpp, VWF multimers and VWF half‐life were examined in mouse strains with and without Mvwf1.Results
A single retro‐orbital bleed and vena cava collection were found to be the optimal methods of blood collection. Problematic collection resulted in release of VWF from platelets and endothelium. The VWFpp/VWF:Ag ratio identified strains of mice with reduced VWF survival.Conclusion
Assay of murine VWFpp and VWF:Ag has utility in determining the acceptability of murine blood samples for coagulation testing and in identification of a reduced VWF survival phenotype in mice.6.
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9.
Kanaji Taisuke; Okamura Takashi; Osaki Koichi; Kuroiwa Mika; Shimoda Kazuya; Hamasaki Naotaka; Niho Yoshiyuki 《Blood》1998,91(6):2010-2014