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排序方式: 共有469条查询结果,搜索用时 109 毫秒
1.
Takaharu Negoro Kanami Orihara Tomoko Irahara Hiroshi Nishiyama Kanae Hagiwara Risa Nishida Hiroki Takagi Kazue Satoh Yoshiki Yamamoto Shunichi Shimizu Tamio Hagiwara Masakazu Ishii Toshihiro Tanioka Yasuko Nakano Ken Takeda Isao Yoshimura Yoji Iikura Takashi Tobe 《Pediatric allergy and immunology》2006,17(8):583-590
Although many single nucleotide polymorphism (SNP) studies have reported an association of atopy, allergic diseases and total serum immunoglobulin E (IgE) levels, almost all of these studies sought risk factors for the onset of these allergic diseases. Furthermore, many studies have analyzed a single gene and hardly any have analyzed environmental factors. In these analyses, the results could be masked and the effects of other genes and environmental factors may be decreased. Here, we described the correlation between four genes [interleukin (IL)-4 (C-590T), IL-4 receptor (A1652G), FCER1B (G6842A) and STAT6 (G2964A)] in connection with IgE production; the role of IL-10 (C-627A) as a regulatory cytokine of allergy; and the severity of food allergy (FA) and atopic eczema (AE) in 220 Japanese allergic children. In addition to these SNPs, environmental factors, i.e., patient's attitude, indoor environment, and so on, were also investigated in this study. Our study was retrospective, and the correlation was analyzed by our defined clinical scores divided into three terms: worst symptoms, recent symptoms and general amelioration at the most recent examination during the disease course. Our results indicated that IL-10 AA, the genotype with lower IL-10 production, is associated with higher IgE levels in the serum (p < 0.0001, estimate; 0.912). Marginal liver abnormalities were observed in the subject group with both FA and AE (p < 0.1191, estimate; 0.1490). Our defined clinical scores enabled evaluation of various aspects of disease severity. Based on the scores, while no single SNP selected in this study determined severity, the combination of the SNP with laboratory data and environmental factors appeared to determine severity. 相似文献
2.
We examined the effects of repetitive experience of feedback events and cue signals on adaptation of bimanual reactive response, both of which can be used to predict load forces on handheld objects. Normal human subjects used bimanual index fingers to hold two plates mounted on separate torque motors. Sensory-driven reactive forces from the fingers were measured during concurrent loading of both plates or isolated loading of the left plate. After repeated experiences of single load conditions, right and left fingers increased normal forces in a coordinated manner during concurrent loading, while the left finger responded almost exclusively during isolated loading of the left plate. However, after switching load conditions from concurrent to isolated load, or vice versa, several trials were needed to adapt to the new condition, as was clearly observed in the dynamic phase of responses from the right finger. Adaptation depends on the number of feedback experiences, and specifically on prediction error, showing intermediate predictions between the two conditions. Thus influences of the previous experiences show similar properties to those observed in self-generated movement, which were reported previously. In addition, auditory cues informing subjects of coming load conditions also partially adapted responses to these conditions. The neuronal center for reactive responses is therefore influenced by both previous experience and cue signals, inducing the appropriate responses for the predicted sensory inputs. 相似文献
3.
Mori S Endo M Nishizawa K Ohno M Miyazaki H Tsujita K Saito Y 《Physics in medicine and biology》2005,50(22):N359-N370
The prototype cone-beam CT (CBCT) has a larger beam width than the conventional multi-detector row CT (MDCT). This causes a non-uniform angular distribution of the x-ray beam intensity known as the heel effect. Scan conditions for CBCT tube current are adjusted on the anode side to obtain an acceptable clinical image quality. However, as the dose is greater on the cathode side than on the anode side, the signal-to-noise ratio on the cathode side is excessively high, resulting in an unnecessary dose amount. To compensate for the heel effect, we developed a heel effect compensation (HEC) filter. The HEC filter rendered the dose distribution uniform and reduced the dose by an average of 25% for free air and by 20% for CTDI phantoms compared to doses with the conventional filter. In addition, its effect in rendering the effective energy uniform resulted in an improvement in image quality. This new HEC filter may be useful in cone-beam CT studies. 相似文献
4.
Hiroji Shinkawa Shogo Tanaka Shigekazu Takemura Ryosuke Amano Kenjiro Kimura Masahiko Kinoshita Kanae Takahashi Shuichiro Matsuzaki Shoji Kubo 《Surgery》2021,169(4):922-928
BackgroundExtrahepatic recurrence and early intrahepatic recurrence of hepatocellular carcinoma after hepatic resection are indicative of poor prognoses. We aimed to develop nomograms to predict extrahepatic recurrence and early intrahepatic recurrence after hepatic resection.MethodsThe participants of this study were 1,206 patients who underwent initial and curative hepatic resection for hepatocellular carcinoma. Multivariate logistic regression analyses using the Akaike information criterion were used to construct nomograms to predict extrahepatic recurrence and early intrahepatic recurrence (within 1 year of surgery) at the first recurrence sites after hepatic resection. Performance of each nomogram was evaluated by calibration plots with bootstrapping.ResultsExtrahepatic recurrence was identified in 95 patients (7.9%) and early intrahepatic recurrence in 296 patients (24.5%). Three predictive factors, α-fetoprotein >200 ng/mL, tumor size (3–5 cm or >5 cm vs ≤3 cm), and image-diagnosed venous invasion by computed tomography, were adopted in the final model of the extrahepatic recurrence nomogram with a concordance index of 0.75. Tumor size and 2 additional predictors (ie, multiple tumors and image-diagnosed portal invasion) were adopted in the final model of the early intrahepatic recurrence nomogram with a concordance index of 0.67. The calibration plots showed good agreement between the nomogram predictions of extrahepatic recurrence and early intrahepatic recurrence and the actual observations of extrahepatic recurrence and early intrahepatic recurrence, respectively.ConclusionWe have developed reliable nomograms to predict extrahepatic recurrence and early intrahepatic recurrence of hepatocellular carcinoma after hepatic resection. These are useful for the diagnostic prediction of extrahepatic recurrence and early intrahepatic recurrence and could guide the surgeon’s selection of treatment strategies for hepatocellular carcinoma patients. 相似文献
5.
Kanae Kaku 《Annals of human biology》2013,40(4):391-393
Although it was expected by observers in Japan that the potency of belief in the superstition of the year of Fire-horse would be made apparent by a decrease in births and an increase of the induced abortion rate, an increase of infant mortality rate was not anticipated. However, an analysis of the early neonatal mortality rate of accidents and violence revealed a remarkable increase for girls but not for boys in 1966, the most recent year of Fire-horse. This fact is consistent with the superstition that women born in the year of Fire-horse are ill-fated. 相似文献
6.
Objective: The purpose of this study was to examine the relationship between
the emotional intelligence quotient and health-related quality of life using structural
equation modeling.Methods: A self-administered questionnaire survey was conducted among 1,911
mothers who visited the Health Center for an infant medical examination. A hypothetical
model was constructed using variables of the emotional intelligence quotient, social
support, coping, parenting stress, and perceived health competence.Result: There were a total of 1,104 valid responses (57.8%). Significant
standardized estimates were obtained, confirming the goodness of fit issues with the
model. The emotional intelligence quotient had a strong impact on physical and
psychological quality of life, and showed the greatest association with coping. This study
differed from previous studies in that, due to the inclusion of social support and
explanatory variables in coping, an increase in coping strategies was more highly
associated with emotional intelligence quotient levels than with social support.Conclusion: An enhanced emotional intelligence quotient should be considered
a primary objective to promote the health of mothers with infant children. 相似文献
7.
Kanae Sakakibara Yoshiki Okayama Kenji Fukushima Shunsaku Kaji Michiko Muraoka Yujiro Arao Akira Shimada 《Pediatrics international》2015,57(5):1023-1024
Congenital factor VII (FVII) deficiency is a rare bleeding disorder with autosomal recessive inheritance. The present female patient was diagnosed with congenital FVII deficiency because of low hepaplastin test (HPT), although vitamin K was given. Heterozygous p.A191T mutation was detected in the peripheral blood, and the same mutation was also found in the mother and sister. To the best of our knowledge, this is the fourth reported case of p.A191T mutation of FVII in the literature and the first to be reported in Japan. FVII coagulation activity (FVII:C) in asymptomatic heterozygous carriers is mildly reduced. Therefore, some patients may not be accurately diagnosed with congenital FVII deficiency. In infants with low HPT without vitamin K deficiency, congenital FVII deficiency should be considered. 相似文献
8.
Hiroaki Kataoka Kazumi Dokai Mochimasu Akihiko Katayama Kanae Oda Kanda Noriko Sakano Keiko Tanaka Nobuyuki Miyatake 《Environmental health and preventive medicine》2015,20(1):63-67
Objective
The aim of this study was to investigate the linkage among climate parameters, total ambulance transports and the number of deaths in Asahikawa City in northern Japan.Methods
Monthly data on total ambulance transports and the number of deaths from January 2004 to December 2011 were obtained from Asahikawa City Fire Department and the Asahikawa City official website. Climate parameters for the required period were also obtained from the Japan Meteorological Agency, Japan. To adjust for the population, we also used monthly population data on Asahikawa City. The linkage among climate parameters, total ambulance transports and the number of deaths was evaluated by ecological analysis.Results
The mean air temperature in the Asahikawa area was 7.3 ± 10.1 °C. Total ambulance transports (/a hundred thousand people/day) and the number of deaths (/a hundred thousand people/day) were 10.0 ± 0.6 and 2.6 ± 0.3, respectively. Using quadratic curves, total ambulance transports and the number of deaths were weakly correlated with some climate parameters. The number of deaths was weakly and positively correlated with total ambulance transports.Conclusion
A weak linkage among climate parameters, total ambulance transports and the number of deaths was noted in Asahikawa City, Japan. However, these associations were not as high as expected. 相似文献9.
Keiji Yamamoto Uichi Ikeda Yoko Ikeda Yoshitane Seino Tetsuo Takayasu Shin-Ichi Ooki Tsutomu Yamaguchi Kanae Fukushima Tsuguo Hasegawa Naohiro Shinohara Kazuyuki Shimada 《Heart and vessels》1993,8(3):166-169
Summary While mural thrombus accompanied by an abdominal aortic aneurysm (AAA) is not rare, the growth rate of such a thrombus has not yet been adequately documented. We present here a very rare case of a 62-year-old female patient with an AAA in whom the mural thrombus in the aneurysm grew very rapidly over a short period. We could follow the growth of the mural thrombus in the AAA by two-dimensional (2-D) abdominal echography. Patients with an AAA must be closely monitored by this technique which is able to detect the presence of the thrombus and allow evaluation of its growth. 相似文献
10.
Ayami Ohno Kishimoto Masako Kataoka Mami Iima Maya Honda Kanae Kawai Miyake Akane Ohashi Rie Ota Tatsuki Kataoka Takaki Sakurai Masakazu Toi Kaori Togashi 《Magnetic resonance in medical sciences》2021,20(2):204
Purpose:We aimed to investigate the performance of high resolution-diffusion-weighted imaging (HR-DWI) using readout-segmented echo-planar imaging in visualizing malignant breast lesions and evaluating their extent, using pathology as a reference.Methods:This retrospective study included patients who underwent HR-DWI with surgically confirmed malignant breast lesions. Two radiologists blinded to the final diagnosis evaluated HR-DWI independently and identified the lesions, measuring their maximum diameters. Another radiologist confirmed if those lesions were identical to the pathology. The maximum diameters of the lesions between HR-DWI and pathology were compared, and their correlations were calculated using Spearman’s correlation coefficient. Apparent diffusion coefficient (ADC) values of the lesions were measured.Results:Ninety-five mass/64 non-mass lesions were pathologically confirmed in 104 females. Both radiologists detected the same 93 mass lesions (97.9%). Spearman’s correlation coefficient for mass lesions were 0.89 and 0.90 (P < 0.0001 and 0001) for the two radiologists, respectively. The size differences within 10 mm were 90.3% (84/93) and 94.6% (88/93) respectively. One radiologist detected 35 non-mass lesions (54.7%) and another radiologist detected 32 non-mass lesions (50.0%), of which 28 lesions were confirmed as identical. Spearman’s correlation coefficient for non-mass lesions were 0.59 and 0.22 (P = 0.0002 and 0.22), respectively. The mean ADC value of mass lesions and non-mass lesions were 0.80 and 0.89 × 10−3 mm2/s, respectively.Conclusion:Using HR-DWI, malignant mass lesions were depicted with excellent agreement with the pathological evaluation. Approximately half of the non-mass lesions could not be identified, suggesting a current limitation of HR-DWI. 相似文献