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An intracranial mixed germ cell tumour with germinoma and teratoma components is reported. The patient presented with parinaud's syndrome and precocious puberty. The treatment involved partial surgical debulking followed by whole brain radiotherapy (4500 cGY in 25 fraction over 5 weeks) and chemotherapy (consisting of cisplatin and etoposide). Post treatment MRI showed no residual lesion. The controversies in the management are discussed. 相似文献
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Sanjiv Sharma S. C. Sharma Sandeep Singhal Y. N. Mehra B. D. Gupta Sushmita Ghoshal A. P. S. Sandhu 《Indian journal of otolaryngology and head and neck surgery》1991,43(4):191-194
A retrospective analysis was performed of 250 cases of carcinoma of the maxillary antrum seen over a 10 years period (1975–1984). 98.24% patients were seen in T3 and T4 stages (UICC 1985). 40.7% patients presented with clinically palpable nodes. 42.9% patients were treated by radical radiation and 18.6% by a combination of preoperative radiation followed by surgery. Rest 38.5% patients were treated with palliative intention. Three year disease free survival was 39.58% with radiation alone and 51.91% with combined modality treatment which includes patients salvaged by surgery. Failures were mainly at the local site, 75.86% with radiation alone and 60% with combined modality treatment. Combined modality treatment, preferably preoperative radiation followed by radical surgery, gives the best results in the management of carcinoma of the maxillary antrum. 相似文献
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Roy Kakali Satapathy Amit Kumar Houhton Jayne A. L. Flanagan Sarah E. Radha Venkatesan Mohan Viswanathan Sharma Rajni Jain Vandana 《Indian journal of pediatrics》2019,86(11):1051-1053
Indian Journal of Pediatrics - Congenital hyperinsulinism (CHI) is a clinically and genetically heterogeneous disorder, characterized by dysregulated insulin secretion. Pathogenic variants in at... 相似文献
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Irritable bowel syndrome in Asia: Pathogenesis,natural history,epidemiology, and management 下载免费PDF全文
Kok‐Ann Gwee Uday Chand Ghoshal Minhu Chen 《Journal of gastroenterology and hepatology》2018,33(1):99-110
Historically, the epidemiology of gastrointestinal diseases in Asia was different from that in Western countries. Early studies suggested a low prevalence of irritable bowel syndrome (IBS) in Asia. As the diagnosis of IBS is symptom‐based and as symptom perception, expression, and interpretation are influenced by sociocultural perspectives including language, the presentation of IBS is expected to vary in different communities. Furthermore, the pathogenesis is multifactorial with psychosocial (stress, illness, behavior, and diet) and biological (infection, gut microbiota, and immune activation) variables interacting, and so, the present study can anticipate that the development of IBS will vary in different environments. In recognition of this aspect of functional gastrointestinal disorders, the recently published Rome IV documents have provided greater focus on cross‐cultural factors. In this review, the present study seeks to highlight Asian perspectives by identifying historical trends and recent publications from the region and comparing these with the observations from Western societies. 相似文献
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Asmita Samadder Jayeeta Das Sreemanti Das Durba Das Arnab De Kakali Bhadra 《中西医结合学报》2012,10(12):1433-1442
目的:研究变黑白头翁提取物降低亚砷酸盐对小鼠精细胞毒性的作用。方法:给予实验小鼠亚砷酸钠(20mg/kg每日),并分别在第30、60、90天对小鼠进行检测。亚砷酸盐中毒小鼠被分为2组,其中一组给予变黑白头翁提取物(35mg/kg),另一组给予85%乙醇。通过检测小鼠精细胞凋亡标志蛋白CYP1A1、p53及caspase3的活性,确定细胞及DNA的损伤情况,并测定睾丸毒性标志物的水平。通过圆二色光谱仪及熔化温度数据检测变黑白头翁提取物与DNA的相互作用情况。结果:亚砷酸盐中毒小鼠的所有细胞凋亡标志蛋白及睾丸毒性标志物的水平均有所上升,而经变黑白头翁提取物治疗的小鼠上述各项指标均降低或恢复至正常水平。变黑白头翁提取物与DNA相互作用,引起了DNA结构和构象的变化。结论:变黑白头翁提取物可作为砷中毒引起的生殖功能损害的治疗药物给予研究和开发。 相似文献
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Rome foundation Asian working team report: Real world treatment experience of Asian patients with functional bowel disorders 下载免费PDF全文
Lishou Xiong Xiaorong Gong Kewin Tien‐Ho Siah Nitesh Pratap Uday Chand Ghoshal Murdani Abdullah Ari Fahrial Syam Young‐Tae Bak Myung‐gyu Choi Ching‐Liang Lu Sutep Gonlachanvit Andrew Seng Boon Chua Kuck‐Meng Chong Jane D Ricaforte‐Campos Quan Shi Xiaohua Hou William E Whitehead Kok‐Ann Gwee Minhu Chen 《Journal of gastroenterology and hepatology》2017,32(8):1450-1456
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