全文获取类型
收费全文 | 335篇 |
免费 | 13篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 140篇 |
基础医学 | 13篇 |
口腔科学 | 3篇 |
临床医学 | 16篇 |
内科学 | 42篇 |
神经病学 | 36篇 |
特种医学 | 10篇 |
外科学 | 38篇 |
综合类 | 3篇 |
一般理论 | 1篇 |
预防医学 | 18篇 |
药学 | 18篇 |
中国医学 | 1篇 |
肿瘤学 | 11篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 4篇 |
2020年 | 4篇 |
2018年 | 1篇 |
2017年 | 5篇 |
2016年 | 10篇 |
2015年 | 3篇 |
2014年 | 9篇 |
2013年 | 9篇 |
2012年 | 16篇 |
2011年 | 20篇 |
2010年 | 30篇 |
2009年 | 13篇 |
2008年 | 11篇 |
2007年 | 40篇 |
2006年 | 19篇 |
2005年 | 28篇 |
2004年 | 43篇 |
2003年 | 28篇 |
2002年 | 20篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 4篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有350条查询结果,搜索用时 15 毫秒
1.
The aim of this study was to examine if adhesion molecules had relation with degeneration and regeneration processes of mammalian vestibular epithelia. The distribution of E-cadherin and beta-catenin was immunohistochemically examined in normal and aminoglycoside-treated utricles of mice. E-cadherin and beta-catenin linearly expressed between epithelial cells in normal specimens. Aminoglycoside injury resulted in temporal alteration in distribution of these molecules with induction of apoptosis in hair cells. Degradation of both molecules was widely observed in vestibular epithelia, while some supporting cells exhibited accumulation of beta-catenin. After completion of induction of apoptosis, expression of these adhesion molecules was normal in distribution. These findings suggest that the E-cadherin-beta-catenin complex plays roles in degeneration and subsequent repair processes in vestibular epithelia affected by aminoglycosides. 相似文献
2.
3.
Danjo K Sakamoto J Iwane S Tamura K Nakaji S Fukuda S Murakami H Shimoyama T Takahashi I Umeda T 《Digestive diseases and sciences》2008,53(3):712-718
We investigated the effects of cellulose supplementation on fecal consistency and fecal weight. About 26 women were classified into two groups-normal defecation and constipation groups. All subjects ate the following meals during the experiment: ordinary meals (first week), experimental meals (second week), and experimental meals mixed with 4 g (third week) and 8 g (fourth week) cellulose. The experimental meal contained 16.7 g fiber. Fecal weights, fecal water content, fecal consistency, and defecation frequency were measured during the experimental period. As a result, in the normal defecation group, the mean fecal weight was 222.9 g day(-1) in the first week, and thereafter decreased. Although 20/24 g of fiber intake in the third/fourth week increased the fecal weight to over 150 g, the fecal consistency was still lower than the optimal consistency of around 300 g cm(-2). However, these changes were not observed in the constipated group. 相似文献
4.
Magnifying endoscope with NBI to predict the depth of invasion in laryngo‐pharyngeal cancer 下载免费PDF全文
Ichiro Tateya MD PhD Shuko Morita MD Manabu Muto MD PhD Shin'ichi Miyamoto MD PhD Tomomasa Hayashi MD PhD Makiko Funakoshi MD Ikuo Aoyama MD Shigeru Hirano MD PhD Morimasa Kitamura MD PhD Seiji Ishikawa MD PhD Yo Kishimoto MD PhD Mami Morita MD Patnarin Mahattanasakul MD Satoshi Morita PhD Juichi Ito MD PhD 《The Laryngoscope》2015,125(5):1124-1129
5.
Sato A Sueoka-Aragane N Saitoh J Komiya K Hisatomi T Tomimasu R Hayashi S Sueoka E 《Journal of cancer research and clinical oncology》2008,134(11):1191-1197
Purpose Development of an early detection marker is one of the most important strategies for improving overall prognosis in lung cancer
patients. We previously reported that hnRNP B1––an RNA binding protein––is overexpressed in lung cancer tissue from the early
stage of cancer, and found that hnRNP B1 mRNA is detectable in the plasma of lung cancer patients using real-time RT-PCR. The purpose of this study was to establish
a quick and simple method for detecting plasma hnRNP B1mRNA for use in screening for lung cancer.
Methods TRC, a homogenous method for fluorescence real-time monitoring of isothermal RNA amplification using intercalation activating
fluorescence DNA probe, was used to detect plasma hnRNP B1 mRNA.
Results The detection limit of hnRNP B1 mRNA by TRC using synthetic control RNA or total RNA derived from a lung cancer cell line was 25 or 8.65 × 102 copies, respectively. Using total RNA extracted from 600 μl of plasma, we detected hnRNP B1 mRNA in 39.1% (9/23) of lung cancer patients, with levels ranging from 1.9 to 19,045.5 copies/100 ng RNA, and in 5.2% (5/97)
of healthy volunteers. Copy numbers were not associated with age, gender, smoking status, or histological type of cancer.
TRC could detect 103 copies of hnRNP B1 mRNA in 10 min.
Conclusion Detection of plasma hnRNP B1 mRNA by TRC is a quick, easy, and non-invasive method suitable for lung cancer screening. 相似文献
6.
7.
Tonosu J Takeshita K Hara N Matsudaira K Kato S Masuda K Chikuda H 《European spine journal》2012,21(8):1596-1602
Purpose
The Oswestry Disability Index (ODI) is one of the most common scoring systems used for patients with low back pain (LBP). Although the normative score of the ODI was reported to be 10.19 in a review article, no study has calculated the normative score after adjusting the value based on the age distribution. In addition, none of the previous studies has estimated the cut-off value which separates LBP with disability from LBP without disability. The purpose of this study was to estimate the normative score by adjusting the data for age distribution in Japan, and to determine the cut-off value which separates LBP with disability from LBP without disability.Methods
We conducted an internet survey on LBP using the Japanese version of the ODQ. A total of 1,200 respondents, composed of 100 males and 100 females in each age group (from the 20s to 70s), participated in this study. We also asked them to provide information about their backgrounds. We estimated the normative score after correcting for the age distribution of Japan. We also estimated the ODI of those with or without disability, the factors associated with the ODI, and the cut-off value which separates LBP with disability from LBP without disability.Results
The participants’ backgrounds were similar to the national survey. The normative score of the ODI was estimated at 8.73. The ODI of the LBP with disability group was 22.07. Those with sciatica and obese subjects showed higher ODI than those without. The optimal cut-off value was estimated to be 12.Conclusions
We defined the normative score and the cut-off value of the ODI. 相似文献8.
Hayashi K Sato J Fujiwara N Kajita M Fukuharu M Hu X Kuriki K Hoshino H Kato R Tokudome S Sato Y 《Environmental health and preventive medicine》2002,7(3):123-128
Objectives To evaluate the physical strength, cerebral function, and mental health conditions in elderly persons, and to examine the
correlation between these functions.
Methods The subjects were 151 independent-living elderly Japanese women, mean age 70 +/-5 years (+/-SD; range, 60 to 80 years), with
normal abilities in daily life. The health check-up was conducted from April to May 1997. Physical strength was estimated
by measuring seven activities. Cerebral functions were assessed by six sub-tests of the General Aptitude Test Battery (GATB).
Their mental health status was measured by four sub-scales of the General Health Questionnaire (GHQ)-28.
Results The physical strenght and almost all of the cerebral functions decreased with age. Social dysfunction and severe depression
on the GHQ sub-scales also worsened with age. Physical strength was strongly correlated with cerebral functions after adjusting
for the confounding effect of aging. There were also interrelations between physical strength and mental health.
Conclusions This study provided important information on the correlation between physical and mental status in elderly women. Future longitudinal
studies with the intervention of physical training are required to determine whether a causal relationship exists between
these factors. 相似文献
9.
Shibata K Suzuki S Sato J Ohsawa I Goto S Iritani I Tokudome S 《Journal of clinical epidemiology》2005,58(10):1052-1057
OBJECTIVES: To compare the sensitivity, specificity, and total accuracy of an HbA1c of > or =6.5% in the detection of hyperglycemia (PPHG) relative to those of a fasting blood glucose (FBG) of > or =7.0 mmol/L. METHODS: A total of 6,010 subjects (2,987 men and 3,023 women) living or working in Kasugai, Japan, underwent a medical checkup at Kasugai City Medical Care Center between April 2001 and March 2002. For the 91 subjects who had either a FBG of > or =7.0 mmol/L or an HbA1c of > or =6.5%, a 75-g oral glucose tolerance test was performed to confirm or exclude PPHG. We calculated the true- and false-positive odds ratios to evaluate the sensitivity and specificity of HbA1c relative to FBG, and compared the overall accuracy by calculating the conditional relative odds ratio (CROR). RESULTS: Among the 91 subjects, the true- and false-positive odds ratios were 0.43 (95% CI 0.26-0.69) and 0.40 (0.13-1.27) (Fisher's exact test, P < .090), respectively; the CROR was 1.07 (95% CI 0.30-3.75). CONCLUSIONS: Although the HbA1c test was marginally more specific but less sensitive than the FBG test, at the given cutoff points the accuracies of two tests were equivalent. 相似文献
10.
Ulcerative colitis (UC) is an idiopathic, non-specific inflammatory disorder involving primarily the mucosa and submucosa of the colon, especially the rectum. It usually produces a bloody diarrhea and various degrees of systemic involvement. These definitions of idiopathic proctocolitis were established by Council for International Organization of Medical Science (CIOMS) in 1973. In Japan, the first criteria for diagnosis of UC were established by the Research Committee of UC (the Japanese Ministry of Health and Welfare) in 1974, based on the definitions by CIOMS. Since then, some minor revisions have been made. The newest criteria for diagnosis of UC were published in 1998. The diagnosis of UC is made on the basis of a combination of clinical, endoscopic, radiologic, and histologic findings. 相似文献