活血化瘀中药治疗血瘀证卵巢癌的研究进展

卵巢癌是一种常见的妇科恶性肿瘤,发病率逐年上升,其死亡率高居女性生殖道恶性肿瘤之首.活血化瘀中药在临床上被广泛用于预防、干预恶性肿瘤转移,中西医结合治疗卵巢癌可显著提高其疗效.通过探讨卵巢癌的病因病机,阐明血瘀证与卵巢癌的关系,并从中药方剂、单味药、中药提取物3个方面对活血化瘀中药治疗血瘀证卵巢癌的概况进行综述,为中医药治疗卵巢癌提供理论基础.     

RhoA在肝纤维化中的作用机制

肝纤维化发生的关键在于肝星状细胞（HSC）转化为成纤维母细胞及活化后细胞外基质（ECM）的异常表达。回顾了Rho/ROCK信号通路在HSC的激活中的重要作用。总结了RhoA,作为Rho/ROCK信号通路上小G蛋白家庭成员之一,且作为一种重要的调节肌动蛋白细胞骨架和细胞形态异质性的细胞因子,参与肝纤维化的进程。指出RhoA在肝脏纤维化发生发展过程中起着重要的调控作用,归纳了RhoA通过调节肌动蛋白应力纤维的装配,并通过级联放大效应影响细胞基质的合成和收缩,最终影响肝纤维化的进展。就RhoA在肝纤维化过程中的机制以及RhoA作为潜在的治疗靶点作一综述。     

叶桂诊治情志致脾胃病

清代叶桂所著《临证指南医案》,治疗情志失调导致的脾胃病时,叶氏汲取李东垣、刘河间、张仲景等著名医家治疗脾胃病的学术经验,创立归纳治疗情志所致脾胃病的3条基本法则:肝胃阴未虚,肝阳犯胃,立法用刚远柔;肝胃阴俱虚,风阳扰胃,立法忌刚用柔;平治肝胃,立法刚柔寒热并用。叶氏重视脾胃,善用人参补中养虚,半夏、枳实、厚朴、姜汁通降胃气,茯苓、陈皮健脾和胃,白芍、乌梅倡养胃阴,壮脾土以制肝木,形成了理法方药一线贯穿的理论体系。     

Ethnic,Gender, and Age Differences in Adolescent Nonfatal Suicidal Behaviors

This study examined ethnic differences in adolescent nonfatal suicidal behaviors as well as age and gender variation both across and within ethnic groups. Using a large (n = 14, 346) sample of adolescents in Grades 7 through 12, African Americans reported relatively high rates of suicidal thoughts and attempts and Southeast Asians reported high rates of suicidal thoughts. Hispanic Americans, European Americans, and Asian Americans were similar in their reports of nonfatal suicidal behaviors. Gender differences also varied across ethnicity as Southeast Asian boys (particularly older boys) reported more suicidal thoughts and attempts than Southeast Asian girls.     

Mediastinal and subglottic hemangioma in an infant: a case report and literature review

We performed a retrospective analysis of the clinical manifestations, laboratory and imaging examinations, treatment, and prognosis of a male infant who was diagnosed with mediastinal and subglottic hemangioma in our hospital. The clinical features of this patient were coughing, wheezing, and dyspnea. Enhanced computed tomography of the neck and chest showed a diffuse abnormality in the right-upper mediastinum. He was diagnosed with a hemangioma after a physical examination combined with bronchoscopy. The clinical symptoms were relieved by oral propranolol. We also investigated the clinical characteristics, treatment, and prognosis of mediastinal and subglottic hemangioma in infants in the previous literature, and searched for case reports of this disease in China and in other countries. We only identified three previous cases of mediastinal and subglottic hemangioma in infants, indicating that this condition is rare. In the proliferative stage, surrounding organs and tissues are compressed, which can be life-threatening. Most of these children develop wheezing, shortness of breath, dyspnea, cyanosis, and other symptoms within 2 months. Enhanced computed tomography and magnetic resonance imaging combined with soft bronchoscopy can confirm the diagnosis of this disease, and oral propranolol achieves a favorable effect.     

中西医结合治疗慢性鼻窦炎100例

<正>慢性鼻窦炎是急性鼻窦炎治疗不及时所致,是耳鼻喉科的常见病和多发病。临床治疗方法很多,疗效不一。我科自2006年以来,采用自拟鼻窦炎方结合西医治疗的     

高胆固醇血症的红细胞变形能力研究

应用德国ＦＭ－４红细胞滤过渡仪及镍金属滤膜检测６７例高胆固醇血症患者及４０例正常对照者的红细胞变形能力及血液粘度。结果，一固醇血症时反映红细胞变形能力的各项指标（最小余量值、初始斜率、０．５０斜率、０．８０斜率）显著异常，说明红细胞变形能力显著降低，同时血液粘度也明显升高，２３例服用辛伐他汀等调脂药物，血胆固醇水平显著降低后，红细胞变形各项指标显著好转，血粘度也趋下降，反映变形能力的敏感指标最小余     

Successful use of continuous ambulatory peritoneal dialysis in octogenarians

This paper reports experience with 18 patients who started CAPD at an age≥80 years at our centre, with emphasis on results, complications and outcome. There were 12 male and 6 female patients whose mean age was 85 years (range 82–91 years); the median duration on CAPD was 31.5 months (range 2 to 58 months). End-stage renal diseases (ESRD) was caused by nephrosclerosis in 9, diabetes mellitus (DM) and light chain disease in 2 each, chronic glomerulonephritis, membranous nephropathy and IgA nephropathy in 1 each, the cause was unknown in yet another two. Seven patients performed their own dialysis while 11 required assistance. The most common co-morbid conditions were hypertension and angina. Peritonitis, that occurred at a rate of 1 episode per 10.8 patient months was responsible for most of the hospitalizations. Peritonitis necessitated catheter removal in 7 patients, reinsertion was done in 6 of them. Fourteen episodes of exit site infection were encountered in 8 patients, 2 developed pericatheter leak and 1 had a tunnel infection. Of the hernias observed in 4 patients, none were inguinal-2 patients each had umbilical and incisional hernias. Nine patients are still continuing CAPD successfully with a median duration of 29 months (range 11–57 months). One patient was transferred to hemodialysis because of congestive heart failure and eight patients died. The causes of death were peritonitis (3/8), CVA (2/8), pneumonia (1/8) and septicemia (1/8). In one patient, the cause of death was not clearly established. Our survival rate of 80% at 3 years is encouraging and hence we advocate CAPD as an acceptable mode of treatment in octogenarians with ESRD.