INTRODUCTION Injury is emerging as the most important preventable cause of death and disability in children beyond the first few months of life[1,2]. In China, injury has become a leading cause of death in children over one year[2]. In addition, injuries … 相似文献
Two new phenanthrene and 9, 10-dihydrophenanthrene derivatives (1–2) with six known congeners (3–8) were isolated from the extraction of stems of Dendrobium officinale. Compounds 1 and 2 were based on carbon skeleton in which phenanthrene and 9, 10-dihydrophenanthrene moiety were linked with a phenylpropane unit through a dioxane bridge, respectively. Their structures were determined by comprehensive NMR spectroscopic data, the absolute configuration of new compounds were determined by comparing their experimental and calculated ECD for the first time. All the compounds were investigated contains two cancer cell lines (HI-60, THP-1). All the isolates showed cytotoxicity, especially compound 4 showed markedly cytotoxic activities against HI-60 and THP-1 cell lines with IC50 values of 11.96 and 8.92 μM.
The effects of aging on the electroencephalogram (EEG) power spectra of 8- and 60-week-old Wistar–Kyoto rats were examined
during the waking baseline and treadmill exercise. Using continuous and simultaneous recordings of EEG and electromyogram
signals, this study demonstrated that the alpha (10–13 Hz), theta (6–10 Hz), and delta (0.5–4 Hz) powers of the EEG were significantly
lower in older rats as compared with young rats during the waking baseline. In the young rats, treadmill exercise resulted
promptly in a higher alpha power, higher theta power, and higher theta power percentage as compared with the waking baseline.
In the aged rats, treadmill exercise only resulted in a higher theta power and higher theta power percentage. During the treadmill
exercise, however, the aged rats still showed a significantly lower exercise-evoked theta power change than the young rats.
These results suggested that aging is accompanied by lower EEG activities during waking and this also is accompanied by an
attenuated response of the brain to exercise in the rat. 相似文献