全文获取类型
收费全文 | 413篇 |
免费 | 23篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 4篇 |
妇产科学 | 16篇 |
基础医学 | 45篇 |
临床医学 | 39篇 |
内科学 | 106篇 |
皮肤病学 | 14篇 |
神经病学 | 33篇 |
特种医学 | 46篇 |
外科学 | 41篇 |
综合类 | 5篇 |
预防医学 | 50篇 |
眼科学 | 4篇 |
药学 | 6篇 |
肿瘤学 | 23篇 |
出版年
2023年 | 3篇 |
2022年 | 4篇 |
2021年 | 9篇 |
2020年 | 7篇 |
2019年 | 8篇 |
2018年 | 14篇 |
2017年 | 11篇 |
2016年 | 9篇 |
2015年 | 9篇 |
2014年 | 7篇 |
2013年 | 11篇 |
2012年 | 17篇 |
2011年 | 18篇 |
2010年 | 18篇 |
2009年 | 11篇 |
2008年 | 14篇 |
2007年 | 24篇 |
2006年 | 18篇 |
2005年 | 15篇 |
2004年 | 13篇 |
2003年 | 24篇 |
2002年 | 17篇 |
2001年 | 22篇 |
2000年 | 16篇 |
1999年 | 10篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 3篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 5篇 |
1992年 | 5篇 |
1991年 | 1篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 7篇 |
1982年 | 5篇 |
1981年 | 11篇 |
1980年 | 5篇 |
1979年 | 13篇 |
1978年 | 9篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1965年 | 1篇 |
1961年 | 1篇 |
排序方式: 共有436条查询结果,搜索用时 15 毫秒
1.
M.F. Werner A. López-Rueda F.X. Zarco J. Blasco L. San Román S. Amaro E. Carrero R. Valero L. Oleaga J.M. Macho N. Bargalló 《Radiologia》2019,61(2):143-152
Purpose
Endovascular treatment with mechanical thrombectomy devices demonstrated high recanalization rates but functional outcome did not correlate with high rates of recanalization obtained. Patient selection prior to the endovascular treatment is very important in the final outcome of the patient. The primary aim of our study was to evaluate the prognostic value of posterior circulation Alberta Stroke Program Early CT Score (pc-ASPECTS) and Pons-Midbrain Index (PMI) scores in patients with Basilar Artery Occlusion (BAO) treated with successful angiographic recanalization after mechanical thrombectomy.Methods
Retrospective single-center study including 18 patients between 2008 and 2013 who had acute basilar artery occlusion managed with endovascular treatment within 24 hours from symptoms onset and with successful angiographic recanalization. The patients were initially classified into two groups according to clinical outcome and mortality at 90 days. For analysis we also divided patients into groups based on pc-ASPECTS (≥8vs.< 8) and PMI (≥3vs.< 3) on non-contrast CT (NCCT) and CT Angiography Source Images (CTASI). Imaging data were correlated to clinical outcome and mortality rate.Results
CTASI pc-ASPECTS, dichotomized at < 8 versus≥8, was associated with a favorable outcome (RR: 2.6; 95% CI: 1.3-5.2) and a reduced risk of death (RR: 6.5: 95% CI: 7.8-23.3). All patients that survived and were functionally independent had pc-ASPECTS score≥8. None of the 5 patients with CTASI pc-ASPECTS score less than 8 survived.Conclusion
PC-ASPECTS on CTASI is helpful for predicting functional outcome after BAO recanalization with endovascular treatment. These results should be validated in a randomized controlled trial in order to decide whether or not to treat a patient with BAO. 相似文献2.
T-cell dysregulation in patients with hyperprolactinemia: effect of bromocriptine treatment 总被引:1,自引:0,他引:1
A Vidaller L Llorente F Larrea J P Mendez J Alcocer-Varela D Alarcon-Segovia 《Clinical immunology and immunopathology》1986,38(3):337-343
We studied four patients with tumoral hyperprolactinemia and normal ovarian function before and after prolactine levels had become normal with treatment with bromocriptine (BrC), a dopamine agonist that inhibits prolactin release. Their proliferative responses to concanavalin A, pokeweed mitogen, and, to a lesser extent, phytohemagglutinin, their spontaneous and concanavalin A-induced suppression, and their production of interleukin 2 were found to be decreased and to correct partially or completely after bromocriptine treatment. The T-cell response to interleukin 2 was low in two patients in whom it increased after BrC treatment. These findings give insight on the immunomodulatory role of prolactin in vivo. 相似文献
3.
4.
Antonio Vidaller Fernando Guadarrama Luis Llorente Juan Pablo Méndez Fernando Larrea Antonio R. Villa Donato Alarcón-Segovia 《Journal of clinical immunology》1992,12(3):210-215
We studied NK cell function in eight patients with pathological hyperprolactinemia by measuring51Cr release by K562 cells exposed to their mononuclear cells and found it decreased compared to normal controls (P<0.01). Bromocriptine (BrC) treatment corrected NK function but also made it more efficient at 12:1 than at 25:1 or 50:1 effector:target ratios (ANOVA;P=0.01). The study of NK cell function in agarose revealed that its decrease in hyperprolactinemia is due to their low active binding to target cells, active killing, and recycling capacity. BrC tended to correct them but also increased recycling capacity to levels higher than those of controls (P<0.05). Sequential studies in three hyperprolactinemic patients before and after BrC showed correction of NK function within 1 week but its increased efficiency at the 12:1 effector:target ratio required 8 weeks. We conclude that hyperprolactinemia decreases NK cell function. BrC corrects this by decreasing prolactin levels but also makes NK function more efficient by increasing the capacity of NK cells to recycle after killing. 相似文献
5.
6.
7.
Prokhorov EF González-Hernández J Vorobiev YV Morales-Sánchez E Prokhorova TE Zaldivar Lelo de Larrea G 《Medical & biological engineering & computing》2000,38(5):507-511
The aim is to compare the mean values of the in vivo electrical characteristics of bioiogical active points (BAPs) with those
of the surrounding human skin. The impedance measurements at BAPs and on the surrounding skin are carried out in vivo on ten
young, healthy people. The results of the measurements show that the BAP resistance RP is smaller, and the capacitance CP is higher, than the corresponding values for skin, RS and CS, respectively, these differences are larger at low frequencies (at f=3 Hz, RS/RP=3.19 and CP/CS=3.2). The mean values of the impedance measurements at the BAPs are different from those measured on the skin. The dependence
of RP and CP on the pressing force, in the range of about 1–5 N, for the BAPs, has a smaller slope than that observed for the surrounding
skin. An equivalent circuit for the BAPs is proposed that describes sufficiently well the experimental results obtained. These
results show that the large dispersion in the observed impedance characteristics of the human body measurements in different
body regions can be related to the influence of the BAPs present under the electrodes. 相似文献
8.
9.
Hypothalamic dopaminergic tone and prolactin bioactivity in women with polycystic ovary syndrome 总被引:3,自引:0,他引:3
Hernández I Parra A Méndez I Cabrera V Cravioto MC Mercado M Díaz-Sánchez V Larrea F 《Archives of medical research》2000,31(2):216-222
BACKGROUND: The present study was carried out to investigate the functional significance of the reduced dopaminergic tone in subjects affected with polycystic ovary syndrome (PCOS). METHODS: Our group evaluated the response of pituitary PRL, LH, FSH, and TSH to the administration of a single 10-mg oral dose of the dopamine (DA) receptor antagonist metoclopramide in lean (n = 7) and obese (n = 8) PCOS women and in 11 regularly cycling age- and weight-matched controls (six lean and five obese). In addition, circulating PRL bioactivity was evaluated by its mitogenic activity on a lymphoma cell bioassay. RESULTS: Oral administration of metoclopramide resulted in a significant increase in serum PRL in all subjects; however, the highest increments, regardless of body mass index (BMI), were observed in control women (p <0.005). Measurements of PRL mitogenic activity on the Nb2 lymphoma cell bioassay revealed a significant increase in the bioactive/immunoreactive (B/I) ratio of PRL under basal and stimulated conditions in obese PCOS subjects (p <0.05). Mean fasting glucose/insulin and glucose/insulin-AUC ratios were significantly lower (p <0.001) in obese PCOS when compared with all other groups. CONCLUSIONS: These data support the existence of low DA hypothalamic tone in PCOS women that is likely involved in the inappropriate LH and PRL secretion frequently seen in this syndrome. In addition, our results suggest changes in PRL bioactivity in obese PCOS that may play a role in the development of hyperinsulinemia; however, whether PRL has a functional significance in the development of the metabolic disturbances frequently seen in PCOS remains to be elucidated. 相似文献
10.