全文获取类型
收费全文 | 8184篇 |
免费 | 540篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 67篇 |
儿科学 | 155篇 |
妇产科学 | 216篇 |
基础医学 | 1094篇 |
口腔科学 | 183篇 |
临床医学 | 1033篇 |
内科学 | 1758篇 |
皮肤病学 | 128篇 |
神经病学 | 823篇 |
特种医学 | 190篇 |
外科学 | 975篇 |
综合类 | 44篇 |
一般理论 | 4篇 |
预防医学 | 835篇 |
眼科学 | 107篇 |
药学 | 496篇 |
中国医学 | 26篇 |
肿瘤学 | 625篇 |
出版年
2023年 | 76篇 |
2022年 | 106篇 |
2021年 | 328篇 |
2020年 | 152篇 |
2019年 | 260篇 |
2018年 | 293篇 |
2017年 | 205篇 |
2016年 | 208篇 |
2015年 | 256篇 |
2014年 | 320篇 |
2013年 | 452篇 |
2012年 | 677篇 |
2011年 | 789篇 |
2010年 | 358篇 |
2009年 | 323篇 |
2008年 | 549篇 |
2007年 | 527篇 |
2006年 | 512篇 |
2005年 | 448篇 |
2004年 | 458篇 |
2003年 | 377篇 |
2002年 | 343篇 |
2001年 | 41篇 |
2000年 | 32篇 |
1999年 | 57篇 |
1998年 | 61篇 |
1997年 | 52篇 |
1996年 | 28篇 |
1995年 | 30篇 |
1994年 | 31篇 |
1993年 | 29篇 |
1992年 | 20篇 |
1991年 | 25篇 |
1990年 | 19篇 |
1989年 | 14篇 |
1988年 | 20篇 |
1987年 | 17篇 |
1986年 | 20篇 |
1985年 | 10篇 |
1984年 | 29篇 |
1983年 | 21篇 |
1982年 | 21篇 |
1981年 | 20篇 |
1980年 | 24篇 |
1979年 | 10篇 |
1978年 | 14篇 |
1977年 | 10篇 |
1976年 | 8篇 |
1974年 | 8篇 |
1973年 | 16篇 |
排序方式: 共有8759条查询结果,搜索用时 31 毫秒
1.
器官移植术是20世纪出现的针对器官功能衰竭的最有效治疗方法,每年拯救全球超过12万例患者。但供器官短缺的现状,与器官移植技术和辅助药物的发展不匹配,制约了器官移植事业的发展。我国自2015年起已成为全球器官捐献和移植大国之一,2017年公民逝世后器官捐献数量超过5 000例,占全球捐献总量的15%以上。黄洁夫教授总结的器官捐献与移植"中国模式"得到了世界卫生组织、国际移植界的高度重视和充分肯定。本文通过整理全球及各国的器官捐献与移植数据,剖析全球现状与发展趋势,进一步探索我国公民器官捐献的影响因素并提出针对性的应对策略,以期实现我国器官捐献和移植的"自给自足"。 相似文献
2.
Melinda G Arnett Lisa M Muglia Gloria Laryea Louis J Muglia 《Neuropsychopharmacology》2016,41(1):245-260
The normal function of the hypothalamic-pituitary-adrenal (HPA) axis, and resultant glucocorticoid (GC) secretion, is essential for human health. Disruption of GC regulation is associated with pathologic, psychological, and physiological disease states such as depression, post-traumatic stress disorder, hypertension, diabetes, and osteopenia, among others. As such, understanding the mechanisms by which HPA output is tightly regulated in its responses to environmental stressors and circadian cues has been an active area of investigation for decades. Over the last 20 years, however, advances in gene targeting and genome modification in rodent models have allowed the detailed dissection of roles for key molecular mediators and brain regions responsible for this control in vivo to emerge. Here, we summarize work done to elucidate the function of critical neuropeptide systems, GC-signaling targets, and inflammation-associated pathways in HPA axis regulation and behavior, and highlight areas for future investigation. 相似文献
3.
Ferdynand Hebal Elissa Port Catherine J. Hunter Bryan Malas Jared Green Marleta Reynolds 《Journal of pediatric surgery》2019,54(4):656-662
Background/purpose
Computed tomography (CT) derived Haller Index (HI) remains the standard for quantifying severity in patient with pectus excavatum (PE). Optical scanning described in literature reports optimistic results and new indices that correlate with HI. This study assessed the feasibility of a handheld White Light Scanner (WLS) to obtain 3D measurements and indices of PE deformity.Methods
From April 2015–April 2017, WLS scanning was conducted by orthotists during clinical visits. Included were children with PE up to 18?years. Analysis assessed correlation of a WLS-derived severity index, Hebal-Malas Index (HMI), with physician measured PE Depth (PED), and CT-derived HI.Results
Of 195 participants, 185(94%) patients with PE were scanned and 127(69%) had complete WLS data. For 88 patients undergoing monitoring, HMI correlated with PED (r?=?0.42, p?=?0.004). For 39 patients with pre-operative CT, HMI demonstrated strong correlation with HI (r?=?0.87, p < 0.0001).Conclusions
WLS demonstrated high feasibility of scanning PE. WLS-derived HMI best correlates with HI for patients with severe pectus deformity. Our current data is suggestive that WLS is best applied for severe deformities and yet to be established for milder deformities. Future yearly WLS will provide data on deformity progression and surgical therapy.Level of Evidence
IV.Type of Study
Diagnostic Study. 相似文献4.
María Cabrerizo Gloria Trallero María José Pena Amaia Cilla Gregoria Megias Carmen Mu?oz-Almagro Eva Del Amo Diana Roda Ana Isabel Mensalvas Antonio Moreno-Docón Juan García-Costa Nuria Rabella Manuel Ome?aca María Pilar Romero Sara Sanbonmatsu-Gámez Mercedes Pérez-Ruiz María José Santos-Mu?oz Cristina Calvo And the study group of “Enterovirus parechovirus infections in children under ?years-old Spain” PI- 《European journal of pediatrics》2015,174(11):1511-1516
5.
Neuropsychological Findings: Myoclonic Astatic Epilepsy (MAE) and Lennox-Gastaut Syndrome (LGS) 总被引:1,自引:0,他引:1
Melissa Filippini Antonella Boni Gloria Dazzani Angelo Guerra Giuseppe Gobbi 《Epilepsia》2006,47(S2):56-59
Summary: Purpose: To identify a specific neuropsychological profile associated with myoclonic astatic epilepsy (MAE) and Lennox-Gastaut syndrome (LGS).
Methods: Seven patients diagnosed with MAE and four patients diagnosed with LGS were selected from patients referred to our Child Neurology Unit. The patients were assessed both clinically (awake, sleep, Holter EEG, seizures frequency, and semiology) and neuropsychologically (IQ, language, attention, visuospatial and visuomotor abilities, and behavior). One representative case of each syndrome is presented here.
Results: The clinical picture of the MAE patient resembled that of an MAE condition associated with transitory epileptic encephalopathy. The neuropsychological findings suggest that electroclinical anomalies can temporarily affect cognitive and behavioral functioning. Early effective antiepileptic drug (AED) treatment was found to improve cognitive outcome. In contrast, LGS was associated with mental retardation, which persisted after seizure control.
Conclusions: At present, it remains difficult to delineate a precise neuropsychological profile associated with MAE and LGS. The cognitive outcome of MAE is variable and depends on the clinical pattern. With regard to LGS, the hypothesis of a genetic predisposition underlying both the epilepsy and the mental retardation is still valid. Alternatively, exposure to subclinical electrophysiological anomalies during a critical period of cerebral development may be responsible for the mental retardation. At the time the clinical manifestations appear, drug treatment, even if effective, would have only limited impact on cognitive outcome. However, early multidisciplinary intervention may help to improve behavior and communicative abilities, enhancing the quality of life of these children and their families. 相似文献
Methods: Seven patients diagnosed with MAE and four patients diagnosed with LGS were selected from patients referred to our Child Neurology Unit. The patients were assessed both clinically (awake, sleep, Holter EEG, seizures frequency, and semiology) and neuropsychologically (IQ, language, attention, visuospatial and visuomotor abilities, and behavior). One representative case of each syndrome is presented here.
Results: The clinical picture of the MAE patient resembled that of an MAE condition associated with transitory epileptic encephalopathy. The neuropsychological findings suggest that electroclinical anomalies can temporarily affect cognitive and behavioral functioning. Early effective antiepileptic drug (AED) treatment was found to improve cognitive outcome. In contrast, LGS was associated with mental retardation, which persisted after seizure control.
Conclusions: At present, it remains difficult to delineate a precise neuropsychological profile associated with MAE and LGS. The cognitive outcome of MAE is variable and depends on the clinical pattern. With regard to LGS, the hypothesis of a genetic predisposition underlying both the epilepsy and the mental retardation is still valid. Alternatively, exposure to subclinical electrophysiological anomalies during a critical period of cerebral development may be responsible for the mental retardation. At the time the clinical manifestations appear, drug treatment, even if effective, would have only limited impact on cognitive outcome. However, early multidisciplinary intervention may help to improve behavior and communicative abilities, enhancing the quality of life of these children and their families. 相似文献
6.
Daniela Brizzolara Anna Chilosi Paola Cipriani Gloria Di Filippo Filippo Gasperini Sara Mazzotti Chiara Pecini Pierluigi Zoccolotti 《Cognitive and behavioral neurology》2006,19(3):141-149
OBJECTIVE: The study aims to verify whether phonologic and rapid automatized naming (RAN) deficits are present and associated in Italian dyslexic children and whether they differentially affect dyslexics with and without a history of previous language delay (LD). BACKGROUND: According to the phonologic core deficit hypothesis, dyslexia may stem from impairment of the representation and manipulation of phonemes and may be closely associated with oral language deficits. However, deficits in tasks not requiring fine-grained phonologic representations, such as RAN, have also been described in dyslexic children. METHODS: Thirty-seven children were selected on the basis of a reading deficit and were assigned to 2 groups according to whether or not they had a history of early LD as determined retrospectively by parental report. A battery of reading and writing, verbal working memory, metaphonologic, RAN, and visual search tests were administered. RESULTS: RAN deficits were shared by most dyslexics (with and without a history of LD), whereas phonologic deficits were mainly associated with a previous LD. This last condition did not result in a more profound impairment of reading and writing decoding skills. CONCLUSION: In a shallow orthography such as Italian, RAN, not phonologic deficits, may represent the main cognitive marker of developmental dyslexia. 相似文献
7.
Lucio Posteraro Fabrizio Pezzoni Emilio Varalda Gloria Fugazza Anna Mazzucchi 《Journal of neurology》1991,238(6):337-339
Summary A patient who developed a unilateral opercular syndrome following a cerebrovascular accident is described. Computed tomography showed that the lesion did not affect the opercular cortex, but involved deep white matter and the head of the caudate nucleus of the left hemisphere. Persistent hypophonia and transient aphasia were associated. Comparison with previous cases is discussed. 相似文献
8.
Antonio Rivera Antonio Yáñez Gloria León-Tello Constantino Gil Silvia Giono Eduardo Barba Lilia Cedillo 《BMC musculoskeletal disorders》2002,3(1):15-7
Background
Mycoplasma fermentans has been associated with rheumatoid arthritis. Recently, it was detected in the joints and blood of patients with rheumatoid arthritis, but it is not clear yet how the bacteria enter the body and reach the joints. The purpose of this study was to determine the ability of M. fermentans to induce experimental arthritis in rabbits following inoculation of the bacteria in the trachea and knee joints. 相似文献9.
Cardiac imaging in the evaluation of patients presenting to the emergency department with chest pain
Conclusions Despite the utility and benefits that each imaging modality has to offer, it is easy to see why there is still no perfect
choice for a noninvasive cardiac imaging modality to assist in the management of chest pain patients. All of the current imaging
techniques have their own significant strengths and weaknesses when compared with other modalities. SPECT and echocardiography
are wellestablished technologies that can directly assess the presence of myocardial ischemia and its functional consequence
on RF; newer and more expensive techniques such as MDCT and CMR can directly assess coronary anatomy and have just started
to be evaluated in the acute chest pain setting. There are no studies that directly compare these technologies, and more data
are clearly needed before the question of whether anatomic imaging versus perfusion/function imaging is the better approach
can be answered. Other comparisons such as relative safety, availability, logistics, and cost-effectiveness between the various
technologies are also lacking.
Of all of the imaging modalities discussed, MCE is the only portable technology. The images do not require expensive software
or other technology for offline processing before interpretation, and any trained cardiologist can read the study at the bedside
or, potentially, over the Internet, providing near-instantaneous results in the acute cardiac setting, where time is of the
essence.
MCE is also relatively cheap compared with other technologies, a potential advantage for payors but not necessarily for payees.
How reimbursement rates and fee structures eventually affect clinical practice is also unknown.
Despite these and other questions that need to be answered before any one technique will be used exclusively, the future of
noninvasive cardiac imaging remains an exciting and ever-changing field. The adaptation of any one of these techniques into
its proper role in the ED Journal of Nuclear Cardiology Wyrick and Wei 753 Volume 13, Number 6;749-55 Cardiac imaging in patients
with chest pain will take considerably more time and effort in terms of research, money, and time-tested clinical experience. 相似文献
10.
Pawan Kumar Dhruva Rao Deborah Clements Michael M. Davies Jared Torkington 《Surgical endoscopy》2007,21(6):1036
We present our comments on the above article. 相似文献