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排序方式: 共有532条查询结果,搜索用时 31 毫秒
1.
Yutaka Yonemura Masataka Segawa Hisashi Matsumoto Kouichirou Tsugawa Itasu Ninomiya Luis Fonseca Takashi Fujimura Kazuo Sugiyama Kouichi Miwa Itsuo Miyazaki 《Surgery today》1994,24(6):488-493
Because gastric cancers located in the upper third of the stomach are difficult to detect at an early stage, the surgical results remain poor. We performed R4 gastrectomy as a radical procedure for 25 patients, involving complete resection of the latero-aortic and interaorticovenous lymph modes above and below the left renal vein, in combination with the ordinary R2 or R3 gastrectomy (the R4 group). These patients were compared with 156 others who underwent R2 gastrectomy alone (the R2 group). There were no significant differences in operation time, blood loss, or the incidence of complications between the two groups; however, when the survival rates of the patients with tumors invading beyond the subserosa were compared, the 5-year survival rate was found to be significantly higher in the R4 group than in the R2 group. Furthermore, in patients with para-aortic nodal involvement, a significant survival advantage was observed in the R4 group, as compared with the R2 group. These results suggest that the R4 gastrectomy is a rational approach for patients with advanced gastric cancer located in the upper third of the stomach. 相似文献
2.
Japan Pancreatoduodenectomy Study Group Ryo Hosotani Masafumi Kogire Tadahiro Takada Hiroyuki Kato Takahiko Funabiki Masumasa Horisawa Takeshi Morimoto Takukazu Nagakawa Toshimichi Nakayama Itsuo Miyazaki Masayuki Imamura 《Journal of Hepato-Biliary-Pancreatic Surgery》1997,4(3):295-303
Endocrine tumor of the pancreas is potentially malignant. A multicenter analysis of these tumors was conducted to clarity
the present status of their surgical management and the subsequent long-term surgical results. The Japan pancreatoduodenectomy
(JPD) study group carried out the study; 368 patients were enrolled and variables related to tumor characteristics, surgery,
and survival were retrospectively analyzed. There were 222 patients with functioning tumor and 143 patients with nonfunctioning
tumor. Malignant tumor was found in 140 of 368 (38%) of the patients, and 63/140 (45%) of these patients had metastatic lesion;
the most common site of the metastasis was liver 34/136 (25%), followed by regional lymph nodes 26/136 (19%). Pancreatic resection
was performed in 91% of patients with nonfunctional tumor and in 83% of those with malignant tumor, and 73% of the pancreatic
resections were done with lymph node dissection. The overall 5-year actuarial survival rate was 76% in patients with malignant
tumor. The actuarial 5-year survival rate was 93% in the patients without metastasis and 83% in patients who received curative
resection. Multivariate analysis showed that the presence or absence of synchronous metastasis was the sole significant prognostic
factor. The results suggest that: (i) malignant endocrine tumor of the pancreas is a curable malignancy when pancreatic resection
with lymph node dissection is adopted and (ii) that synchronous metastasis is the dominant prognostic factor.
This study was carried out as a group project. The authors' institutions are as follows 相似文献
3.
I. Gorai Y. Taguchi O. Chaki M. Nakayama H. Minaguchi 《Calcified tissue international》1997,60(4):317-322
Urinary excretion of cross-linked N-telopeptide of type I collagen (NTx) has been reported to be a specific marker of bone
resorption [18]. We assessed a new immunoassay for NTx as an indicator of changes in bone resorption caused by spontaneous
menopause and compared cross-sectionally the levels of urinary NTx, hydroxylysylpyridinoline (HP), lysylpyridinoline (LP),
hydroxyproline (OH-Pr), other serum biochemical indices, and lumbar spine and proximal femur bone mineral density (BMD). Eighty-one
Japanese women aged 22–77 participated in this study; 36 were premenopausal and 45 were postmenopausal. Urinary HP, LP, and
NTx stayed at low levels in the premenopausal period and rose 21%, 30%, and 67% in the postmenopausal period, respectively.
The rise in LP and NTx was statistically significant (P < 0.01), suggesting that NTx is mostly released from bone matrix when bone resorption is accelerated. When premenopausal
women were divided into two age groups and postmenopausal women were divided into two groups according to years since menopause
(YSM) there were significant differences in LP and NTx between women <4 YSM and women aged <40 and those women aged 41+ (P < 0.01 and P < 0.05, respectively). A significant 110% increase in urinary NTx and a 48% increase in urinary LP were observed in postmenopausal
women compared with age-matched premenopausal women aged 45–55. All biochemical markers other than serum PTH correlated significantly
with each other (r = 0.243–0.858, P < 0.05–0.0001). Urinary NTx inversely correlated with lumbar spine BMD. When postmenopausal women were divided into three
groups, the correlation between bone resorption and formation markers in women 0-1 YSM was greater than in women 2–10 YSM
and in women 11 + YSM, indicating that resorption and formation are coupled at the early postmenopausal period. We conclude
that urinary NTx is responsive to changes in bone metabolism caused by estrogen deficiency and may be a more sensitive and
specific marker than HP, LP, or OH-Pr in the early postmenopausal years.
Received: 15 February 1995 / Accepted: 18 October 1996 相似文献
4.
5.
Itsuo Yokoyama Tadamasa Yoneda Itaru Ichimura Shigehisa Kitagawa Yoshiki Okazaki Hiroshi Takagi 《Surgery today》1986,16(6):460-463
In seven patients undergoing right hemicolectomy for benign or malignant diseases, latero-lateral end anastomoses were made
using stapling devices, LS (linear stapler) and GIA (gastrointestinal anastomosis). As no complications directly related to
the anastomosis occurred, we conclude that anastomosis using stapling devices for right hemicolectomy is a safe and rapid
procedure. 相似文献
6.
Yuka Sakazume Makoto Tanaka Itsuo Isobe Rika Tominaga Eiji Nanba Koichi Okamoto 《Clinical neurology》2004,44(8):541-544
We reported a patient with middle-aged onset sialidosis type I. A 52-year-old Japanese man was referred to our hospital because of dysarthria, involuntary movement of his extremities and gait disturbance since the age of 46 years. On admission, neurological examination revealed scanning speech, action myoclonus, cerebellar ataxia and cherry-red spots. Vacuolated lymphocytes were found in peripheral blood. Brain 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET) showed decreased glucose metabolism in the cerebellum. Enzymological analysis using his skin fibroblasts revealed primary deficiency of sialidase activity. Sialidase gene analysis identified compound heterozygotes for base substitusions of 239T-to-C and 649G-to-A, which resulted in amino acid alterations of P80L and V217M, respectively. These mutations have been reported in Japanese sialidosis type II (P80L) and I (V217M). Further studies are required to reveal effects of gene mutations on residual enzyme activities and phenotypes. 相似文献
7.
Tetsuo Ohta Takukazu Nagakawa Hiroshi Itoh Luis Fonseca Itsuo Miyazaki Tadashi Terada 《Journal of gastrointestinal cancer》1993,14(3):283-289
Summary We present a serous cystadenoma of the pancreas with focal malignant changes, and describe its characteristic histological
features. On gross examination, a tumor was present on the anterior surface of the body of the pancreas and measured approx
25×25⋻20, mm. Microscopically, most tumor cells showed the typical histological features of serous cystadenoma, characterized
by a microcystic architecture and glycogenrich cells with a uniform and bland appearance. However, in some areas, a tendency
to papillary structures with fibrovascular cores was noted. These papillary lesions were composed mainly of nonmucinous, glycogen-poor
epithelial cells, the nuclei of which showed a mild atypia. In addition, vascular and perivascular invasion was focally observed.
However, there was no clinical evidence of local or distant metastasis. From these findings, we diagnosed this lesion as a
serous cystadenoma of the pancreas with focal malignant changes rather than a serous cystadenocarcinoma of the pancreas. 相似文献
8.
9.
Masaru Kishida Hiroki Nakazono Rei Kuroiwa Hidenori Dokai Junko Nakazato Hiroaki Nakamura Itsuo Suzuki Noriaki Shinomiya 《Arerugī》2007,56(11):1372-1377
BACKGROUND: Relationship between post administrative changes in plasma drug levels and bronchodilation remains unknown. In this study, we measured plasma levels of procaterol, a beta2-agonist, when being inhaled through nebulizers in children with bronchial asthma to examine relationship between improvement of pulmonary function and the plasma levels. METHOD: Six asthmatic children with the mean age of 9.8 years, inhaled 0.3 ml of 0.01% procaterol solution through a nebulizer. We examined changes in pulmonary function and plasma procaterol levels before and after inhalation. RESULTS: Procaterol was detected in the plasma 2 minutes after inhalation when it already rose to the maximum level, and kept the steady until showing a decline in 30 minutes. The measured highest value was 87.8+/-45.1 pg/ml. FEV 1.0 remarkably increased 2 minutes after inhalation and was maintained until 60 minutes after inhalation. Other lung function parameters also improved. There was no significant change in the heart rate, but serum potassium concentrations significantly dropped in all patients 60 minutes after inhalation. CONCLUSION: Plasma procaterol levels promptly rose to the peak at 2 minutes after inhalation and decreased 30 minutes later. Improvement of pulmonary function started promptly at minutes after inhalation and it became a peak 60 minutes later. 相似文献
10.
HIV-1-specific cell-mediated immune responses induced by DNA vaccination were enhanced by mannan-coated liposomes and inhibited by anti-interferon-gamma antibody. 总被引:2,自引:0,他引:2
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S Toda N Ishii E Okada K I Kusakabe H Arai K Hamajima I Gorai K Nishioka K Okuda 《Immunology》1997,92(1):111-117
The adjuvant effect of mannan-coated liposomes on human immunodeficiency virus type-1 (HIV-1) DNA vaccine and the mechanism of this enhancement were studied. Coating of cationic liposomes with mannan significantly enhanced the ability of this vaccine to induce an HIV-specific delayed-type hypersensitivity (DTH) response. HIV-specific cytotoxic T-cell (CTL) activity elicited by DNA vaccination was also significantly enhanced with the mannan-liposome cocktail. This mannan-liposome-mediated activity was greatly inhibited by in vivo injection of anti-interferon (IFN)-gamma antibody, which suggests that IFN-gamma plays an important role in this HIV-specific immune response. The results of both isotype-specific antibody and cytokine analysis revealed that mannan-liposome-mediated DNA vaccination enhances Th1-mediated immunity. 相似文献