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排序方式: 共有1773条查询结果,搜索用时 15 毫秒
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Leonidas JC; Berdon WE; Valderrama E; Neveling U; Schuval S; Weiss SJ; Hilfer C; Godine L 《Radiology》1996,198(2):377
5.
JC Sitek† M Loeb‡ JR Ronnevig¶ 《Journal of the European Academy of Dermatology and Venereology》2007,21(7):891-896
BACKGROUND: Since 1997, a number of trials have shown promising results in treating generalized vitiligo with narrowband ultraviolet B (UVB) both in adults and children. However, there is little knowledge concerning the duration and permanency of the treatment-induced repigmentation. OBJECTIVE: Our main objective was to perform a follow-up trial of successfully treated patients receiving narrowband UVB for generalized vitiligo. METHODS: We have investigated to what degree the treatment-induced repigmentation remains stable for up to 2 years post-treatment. We performed an initial open trial including 31 patients with generalized vitiligo. They received narrowband UVB thrice weekly for up to 12 months. Patients experiencing > 75% repigmentation were defined responders and were included in the follow-up trial. Responders were followed every 6 months for up to 2 years after cessation of treatment. We observed the pigmentation status and registered any changes indicating loss of pigmentation and relapse. RESULTS: Eleven of the 31 treated patients were included in the follow-up trial. Six patients had relapse and five patients had stable response 24 months after cessation of treatment. Four out of six relapses were within 6 months post-treatment. CONCLUSION: In our study population of 31 patients with generalized vitiligo, five patients (16%) experienced > 75% stable repigmentation 2 years after cessation of a treatment programme of up to 1 years narrowband UVB therapy. 相似文献
6.
Ongoing pregnancies after intracytoplasmic injection using cryopreserved testicular spermatozoa 总被引:4,自引:2,他引:2
Perraguin-Jayot S; Audebert A; Emperaire JC; Parneix I 《Human reproduction (Oxford, England)》1997,12(12):2706-2709
We report two clinical pregnancies occurring after intracytoplasmic sperm
injection (ICSI) using cryopreserved spermatozoa obtained from testicular
biopsy, made in two different infertility situations in our clinic. The
first patient showed a secretory azoospermia associated with elevated serum
follicular stimulating hormone (FSH) level and spermiogenesis maturation
arrest. The second patient was affected by azoospermia resulting from
bilateral epididymal obstruction. Spermatozoa present in the wet
preparation of testicular biopsy made on the day of scrotal exploration
were cryopreserved within the testicular tissue for both men.
Intracytoplasmic injections were performed at a later date, using
spermatozoa prepared from frozen-thawed tissues. In each case, three
embryos were obtained and transferred in utero. The transfers resulted in a
twin pregnancy for the first case, and in a singleton pregnancy for the
second. Living foetuses were seen in the ultrasound scan at the 7th week
and both pregnancies are proceeding to date beyond 30 weeks without
complications.
相似文献
7.
Environmental and genetic determinants of the hypercoagulable state and cardiovascular disease in renal transplant recipients 总被引:4,自引:1,他引:3
Background. Fibrinogen and factor VII coagulant
activity (VIIc), risk factors for cardiovascular disease (CVD) in the
general population, could contribute to CVD risk in renal transplant
recipients (RTR). Methods. We measured fibrinogen and
VIIc in 38 RTR and 31 controls, along with prothrombin fragment F1+2 and
D-Dimer (markers of coagulation and fibrinolytic activation), plasma lipids
and the acute phase response cytokine, interleukin 6. The effect of genetic
polymorphisms of {beta}-fibrinogen (G/A-455) and
factor VII (Arg/Gln353) was explored. Results. F1+2,
D-Dimer, and fibrinogen were increased in all RTR, indicating a chronic
prothrombotic state. Fibrinogen correlated with age, F1+2, and trough
cyclosporin A (CsA). RTR carriers of the A-455
allele had a greater increment in plasma fibrinogen concentration and
correlation with CsA than homozygotes for the G-455
allele. Interleukin 6 was increased in RTR confirming that a persistent
low-grade acute-phase response could contribute to increased fibrinogen.
Differences in plasma VIIc were associated with factor VII genotype,
disease status, and blood lipids. Carriers of the Gln353 allele had 30
lower VIIc when compared with Arg353 homozygotes, which could confer a
reduced thrombotic risk. The 12 RTR with CVD or metabolic complications
(RTR+) were more hyperlipidaemic and had higher fibrinogen and VIIc than
the 26 RTR free of disease complications (RTR-), or the controls.
Conclusions. Long-term RTR manifest features of a
chronic prothrombotic and persistent inflammatory state. Alterations in
fibrinogen and VIIc in RTR arise in part as a result of interactions
between common genetic and environmental factors, and these changes could
contribute to the increased risk of CVD in RTR. 相似文献
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Pernes JM; Vitoux JF; Brenoit P; Raynaud A; Parola JL; Roth JP; Angel CY; Fiessinger JN; Roncato M; Gaux JC 《Radiology》1986,158(2):481-485
Thirty-five patients hospitalized for recent angiographically documented arterial occlusion in the legs (27 femoropopliteal arteries and eight grafts) benefited from local fibrinolytic therapy delivered at the site of the occlusion with a 4- or 5-F catheter. This therapy combined a continuous urokinase (UK) infusion of 1,000 U/kg/hour and a lysyl plasminogen (LYS-PLG) infusion of 15 microkatals every 30 minutes. Angiographically confirmed lysis was obtained in 85% of the cases. Only 3% of the patients had major and 6% had minor groin hematomas. Only two patients had concentrations of fibrinogen as low as 100 mg/dl. Intravascular infusion of UK-LYS-PLG is as effective as streptokinase. Its excellent tolerance makes it a good alternative in the treatment of acute ischemia in the lower limbs. 相似文献