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Long-term protective immune response elicited by vaccination with an expression genomic library of Toxoplasma gondii 总被引:2,自引:0,他引:2 下载免费PDF全文
Fachado A Rodriguez A Molina J Silvério JC Marino AP Pinto LM Angel SO Infante JF Traub-Cseko Y Amendoeira RR Lannes-Vieira J 《Infection and immunity》2003,71(9):5407-5411
Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine. 相似文献
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Evidence of a diverse T cell receptor repertoire for acetylcholine receptor,the autoantigen of myasthenia gravis 总被引:1,自引:0,他引:1
Infante AJ Baillargeon J Kraig E Lott L Jackson C Hämmerling GJ Raju R David C 《Journal of autoimmunity》2003,21(2):167-174
We utilized two methods to look for T cell clonal expansions in myasthenia gravis (MG). We analyzed TCRBV CDR3 length polymorphism (spectratyping) to look for evidence of clonal expansion of CD4 or CD8 T cells directly from peripheral blood of MG patients. No statistically significant differences were found between the diversity of TCR repertoires in MG patients compared to normal control individuals when analyzed as groups. Rare oligoclonal expansions were detected in some individual MG patients but the significance of these findings is unclear. Next, we analyzed a panel of T cell hybridomas from acetylcholine receptor (AChR) immunized, MG-susceptible HLA-DR3 transgenic mice. The epitope specificity, TCRBV gene usage and CDR3 sequences of these hybridomas were highly diverse. We conclude there is only limited evidence for restricted TCR repertoire usage in human MG and suggest this may be due to the inability of HLA-DR molecules to select for restricted TCR recognition of AChR epitopes. 相似文献
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Loizaga Iriarte A Arciniega García JM Infante Riaño R Ullate Jaime V García Sastre E Flores Corral N 《Actas urologicas espa?olas》1999,23(10):873-875
We report a strange case of a bladder whose first metastasic manifestation, after two years of the diagnosis, was a peripheric polyneuropathia. This patient was treated with immunotherapy with BCG for superficial carcinoma of the bladder during one year. Gradually central neurological symptoms appeared and the patient died one month later. A meningeal carcinomatosis was identify as the cause. No bone metastases existed, which is the most frequent way of tumours extension towards leptomeninges. We argue about the way to arrive at meninges. 相似文献
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R Infante de German-Ribon A D Singh J F Arevalo W Driebe T Eskin 《American journal of ophthalmology》1999,128(2):251-253
PURPOSE: To describe three Hispanic patients with oculodermal melanocytosis and uveal melanoma. METHOD: Case series. RESULTS: Three Hispanic patients with oculodermal melanocytosis and uveal melanoma underwent enucleation. The diagnosis of choroidal melanoma was confirmed by histopathologic examination. CONCLUSION: In the Hispanic population, uveal melanoma can occur in the presence of oculodermal melanocytosis. 相似文献
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