全文获取类型
收费全文 | 1847篇 |
免费 | 64篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 146篇 |
妇产科学 | 79篇 |
基础医学 | 117篇 |
口腔科学 | 60篇 |
临床医学 | 158篇 |
内科学 | 340篇 |
皮肤病学 | 30篇 |
神经病学 | 86篇 |
特种医学 | 102篇 |
外科学 | 366篇 |
综合类 | 24篇 |
预防医学 | 37篇 |
眼科学 | 95篇 |
药学 | 143篇 |
中国医学 | 9篇 |
肿瘤学 | 97篇 |
出版年
2024年 | 1篇 |
2023年 | 10篇 |
2022年 | 13篇 |
2021年 | 34篇 |
2020年 | 27篇 |
2019年 | 34篇 |
2018年 | 39篇 |
2017年 | 43篇 |
2016年 | 46篇 |
2015年 | 68篇 |
2014年 | 56篇 |
2013年 | 81篇 |
2012年 | 123篇 |
2011年 | 97篇 |
2010年 | 64篇 |
2009年 | 59篇 |
2008年 | 134篇 |
2007年 | 161篇 |
2006年 | 125篇 |
2005年 | 145篇 |
2004年 | 135篇 |
2003年 | 130篇 |
2002年 | 121篇 |
2001年 | 31篇 |
2000年 | 19篇 |
1999年 | 22篇 |
1998年 | 10篇 |
1997年 | 8篇 |
1996年 | 13篇 |
1995年 | 14篇 |
1994年 | 12篇 |
1993年 | 7篇 |
1992年 | 9篇 |
1990年 | 2篇 |
1988年 | 5篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 3篇 |
1973年 | 1篇 |
排序方式: 共有1919条查询结果,搜索用时 15 毫秒
1.
Aging alters bladder functions where a decrease in filling, storage and emptying is observed. These changes cause urinary incontinence, especially in women. The aim of this study is to examine how aging affects the intracellular calcium movements due to agonist-induced contractions in permeabilized female rat bladder. Urinary bladder isolated from young and old female Sprague-Dawley rats were used. Small detrusor strips were permeabilized with β-escin. The contractile responses induced with agonists were compared between young and old groups. Carbachol-induced contractions were decreased in permeabilized detrusor from old rats compared to young group. Heparin and ryanodine decreased carbachol-induced contractions in young rats where only heparin inhibited these contractions in olds. Caffeine-induced contractions but not inositol triphosphate (IP3)-induced contractions were decreased in old group compared to youngs. The cumulative calcium response curves (pCa 8–4) were also decreased in old rats. Carbachol-induced calcium sensitization responses did not alter by age where GTP-β-S and GF-109203X but not Y-27632 inhibited these responses. Carbachol-induced contractions decrease with aging in rat bladder detrusor. It can be postulated as IP3-induced calcium release (IICR) is primarily responsible for the contractions in older rats where the decrease in carbachol contractions in aging may be as a result of a decrease in calcium-induced calcium release (CICR), rather than carbachol-induced calcium sensitization. 相似文献
2.
3.
4.
Osman Inci Esat Kaya Bulent Alagol Irfan Huseyin Atakan Sabahattin Aydin Hasan Ereselli 《International urology and nephrology》2003,36(1):1-4
Methods: Second primary cancers constitute approximately 9–10% of malignancies diagnosed in the United States. We aimed to show the
risk and incidance of second primary tumor occuring associated to urologic tumors and show the distrubution of tumors in Tracia
region. We retrospectively examined the patients' files with the diagnosis of malignant disease between the years 1985–2000.
Hazard function analysis was performed to estimate the relative risk of secondary malignancy occuring. Age, sex and tumor
number were examined to find out if they affect on mortality rate. Results: A total number of 25 MPMNs were diagnosed. In 52 percent of the cases the second primary neoplasm developed within six months.
The relative risk of development of a second neoplasm is found as increasing 1.111 times per month. The incidence of secondary
malignancy occuring in the patients with one tumor was found as 6.31%. Age (p < 0.001) and tumor number (p < 0.001) are found as statistically effective predictor on mortality rate where the sex is not. Conclusions: In the patients with a primary tumor not only the metastasis must be investigated but also second primary tumors should be
taken in to consideration.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
5.
Engin Altinta? Dilek O?uz Sabite Ka?ar Yasemin Ozderin Orhan Sezgin Neslihan Inci Zengin 《The Turkish journal of gastroenterology》2004,15(1):49-52
Dydrogesterone, similar to women's natural progesterone, has been used in a wide range of gynecological conditions. Despite its widespread use, dydrogesterone-induced hepatotoxicity and dydrogesterone-induced hemolytic anemia have, to the best of our knowledge, never been reported previously. We describe a case of hepatitis and warm antibody hemolytic anemia due to dydrogesterone. 相似文献
6.
A family with cardiac malformation, cleft lip-palate, short stature, microcephaly, distally placed thumbs, short 2nd and 5th fingers, long and broad 1st toes, broad distance between 1st and 2nd toes and mediodorsal curvature of the 4th toes with syndactyly of the 2nd and 3rd toes has been described as having a new syndrome. While some members of the family had full signs of the syndrome, others had similar but fewer and less severe anomalies of the same structures. The presence of common findings in three generations, its variable expressivity and pleiotropism, and the non-consanguineous history in the parents suggest that the inheritance is autosomal dominant. 相似文献
7.
Gastric mucosal damaged induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action.In memory of Dr. Ilker Aykaç whom we have started with. 相似文献
8.
Ozer E Sengül AM Gedik S Salman S Salman F Sargin M Işsever H Satman I Yilmaz T 《Patient education and counseling》2003,51(1):39-44
To examine the influence of diabetes education on well-being, 255 patients with type 2 diabetes were recruited according to whether they attended a diabetes education program (n=126) or not (n=129). In patients who had participated in the program, the mean anxiety score was significantly lower, whereas positive well-being and general well-being scores were significantly higher than for patients who had not participated. Factors related to lower well-being included: being female, taking insulin, not attending a diabetes education program and having HbA(1c) level greater than 8%. The odds of having better well-being were two-fold higher in patients participating the diabetes education program compared with those who had not. Diabetes education has a crucial role in improving the well-being of patients with type 2 diabetes. All patients with diabetes should be encouraged to attend a diabetes education program. 相似文献
9.
Yaylim I Isbir T Oztürk O Turna A Işitmangil T Zonüzi F Camlica H 《Cancer Genetics and Cytogenetics》2002,134(2):118-122
A potential molecular marker associated with cancer susceptibility as well as metastasis, prognosis and adverse survival, is the L-myc gene. The studies of lung cancer patients from different populations have yielded controversial results. We studied 64 nonsmall cell lung cancer (NSCLC) patients and 37 healthy controls of Turkish origin for L-myc gene polymorphism. Our aim was to test the hypothesis that there was association between L-myc S allele in NSCLC and predisposition to the disease and TNM stage indicating tumor size, node classification and metastasis. Polymerase chain reaction restriction fragment length polymorphism and agarose gel electrophoresis were used to determine the L-myc oncogene genotypes. We found no significant difference, both in the distribution of the LL, LS and SS genotypes and in the allelic frequencies, between the patient group and the control group; that is, the frequencies of L-myc alleles were, L and S, 0.59 and 0.41, 0.60 and 0.40, respectively. Our data between the patient group and the control group; that is, the frequencies of L-myc alleles were, L and S, 0.59 and 0.41, 0.60 and 0.40, respectively. Our data concerning age, sex, size of tumors, histological type of tumors showed no significant association with L-myc genotype. However, a higher frequency of L-myc S allele in the squamous cell carcinoma compared to other histological groups was found, although this difference was not statistically significant. No association was found between the L-myc RFLP and increased risk of metastasis either to the lymph nodes or to other organs. Our results suggested that L-myc gene polymorphism was not a suitable prognostic marker of metastatic development in Turkish NSCLC patients. 相似文献
10.
Ilhan Kaya Nazife Yigit Mehlika Benli 《African journal of traditional, complementary, and alternative medicines》2008,5(4):363-369
The antimicrobial activities of chloroform, acetone and two different concentrations of methanol extracts of Ocimum basilicum L. were studied. These extracts were tested in vitro against 10 bacteria and 4 yeasts strains by the disc diffusion method. The results indicated that the methanol extracts of O. basilucum exhibited the antimicrobial activity against tested microorganisms. While the chloroform and acetone extracts had no effect, the methanol extracts showed inhibition zones against strains of Pseudomonas aeruginosa, Shigella sp., Listeria monocytogenes, Staphylococcus aureus and two different strains of Escherichia coli. The cells of microorganisms, which were treated and untreated with plant extracts, were observed by using the scanning electron microscope. It was observed that the treated cells were damaged. 相似文献