全文获取类型
收费全文 | 2659篇 |
免费 | 117篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 46篇 |
妇产科学 | 85篇 |
基础医学 | 460篇 |
口腔科学 | 91篇 |
临床医学 | 173篇 |
内科学 | 576篇 |
皮肤病学 | 36篇 |
神经病学 | 266篇 |
特种医学 | 73篇 |
外科学 | 280篇 |
综合类 | 7篇 |
预防医学 | 93篇 |
眼科学 | 60篇 |
药学 | 212篇 |
中国医学 | 17篇 |
肿瘤学 | 295篇 |
出版年
2023年 | 9篇 |
2022年 | 25篇 |
2021年 | 36篇 |
2020年 | 24篇 |
2019年 | 34篇 |
2018年 | 59篇 |
2017年 | 50篇 |
2016年 | 45篇 |
2015年 | 42篇 |
2014年 | 55篇 |
2013年 | 84篇 |
2012年 | 132篇 |
2011年 | 125篇 |
2010年 | 81篇 |
2009年 | 77篇 |
2008年 | 127篇 |
2007年 | 150篇 |
2006年 | 138篇 |
2005年 | 166篇 |
2004年 | 162篇 |
2003年 | 141篇 |
2002年 | 163篇 |
2001年 | 80篇 |
2000年 | 73篇 |
1999年 | 67篇 |
1998年 | 52篇 |
1997年 | 28篇 |
1996年 | 30篇 |
1995年 | 24篇 |
1994年 | 20篇 |
1993年 | 19篇 |
1992年 | 42篇 |
1991年 | 40篇 |
1990年 | 35篇 |
1989年 | 50篇 |
1988年 | 28篇 |
1987年 | 29篇 |
1986年 | 27篇 |
1985年 | 25篇 |
1984年 | 40篇 |
1983年 | 16篇 |
1982年 | 17篇 |
1981年 | 9篇 |
1980年 | 8篇 |
1979年 | 13篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1974年 | 8篇 |
1973年 | 8篇 |
1971年 | 10篇 |
排序方式: 共有2783条查询结果,搜索用时 0 毫秒
1.
2.
Shuichi Sato Fumiko Nasu Katsutoshi Motegi 《Journal of oral and maxillofacial surgery》2002,60(8):867-872
PURPOSE: The purpose of this study was to examine changes of chewing movement and masticatory efficiency during the natural course of nonreducing disc displacement of the temporomandibular joint (TMJ). PATIENTS AND METHODS: The subjects were 15 patients who had been diagnosed with nonreducing disc displacement of the TMJ but had received no treatment. Chewing movement and masticatory efficiency were examined at the initial visit and at a mean follow-up of 21.7 months, using mandibular kinesiography and adenosine triphosphate ebteric-coated granules. As a control, 23 persons who had no current or previous TMJ symptoms were studied. RESULTS: The patients' clinical signs and symptoms tended to be alleviated during the follow-up period. In normal controls, chewing movement showed lateral excursion to the chewing side on both the right and left sides. In patients, chewing movement at the initial visit showed lateral excursion to the chewing side during chewing on the TMJ affected side, but no such deviation was noted during chewing on the TMJ unaffected side in the horizontal plane. However, chewing movement at follow-up became similar to that of controls. In patients, masticatory efficiency became better during the natural course, although that at follow-up did not always reach the control's level. CONCLUSION: In untreated patients with nonreducing disc displacement of the TMJ, chewing movement and masticatory efficiency tend to improve spontaneously. 相似文献
3.
4.
Jose S. Pulido Ikuko Sugaya Jordan Comstock Kiminobu Sugaya 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2007,245(6):889-893
Purpose Reelin is important in the guidance of neuronal stem cells in the central nervous system during normal development. We wished
to determine whether reelin is expressed in the retina and cornea after injury.
Methods Mice underwent laceration of their retina as well as corneal epithelial debridement. The mice were sacrificed at 3 days, and
eyes were fixed and stained for reelin expression and reelin messenger ribonucleic acid (mRNA).
Results In normal eyes, reelin was expressed only at very low levels in the ganglion cell layer of the retina and the endothelial
cell layer of the cornea. In injured eyes, there was marked expression in reelin immunoreactivity in the retina and cornea.
Reelin gene expression was seen in the retina and cornea.
Conclusions Reelin is expressed during normal retinogenesis. This study shows that reelin is also upregulated following injury to the
retina and cornea. The expression of reelin following injury suggests that reelin may play an important role in regulating
stem cell trafficking in neuronal and nonneuronal tissues following injury similar to its role in normal organogenesis.
For consideration of publication in Graefe’s Archive for Clinical and Experimental Ophthalmology. 相似文献
5.
Six normal men performed cycle ergometer exercise from 50 W to 125 W in a room maintained at 26 degrees C. Capsaicin was introduced by iontophoresis into the forearm skin. Forearm skin blood flow (FSBF) during graded exercises before and after capsaicin treatment was measured by laser Doppler flowmetry. Forearm skin blood flow before capsaicin treatment increased depending on the intensity of exercise. However, forearm skin blood flow 24 hours after capsaicin treatment scarcely increased during graded exercise. The cause of this capsaicin effect was discussed. 相似文献
6.
7.
A case-control study of breast cancer among Japanese women: with special reference to family history and reproductive and dietary factors 总被引:8,自引:0,他引:8
Dr. Ikuko Kato Dr. Shigeto Miura Fijio Kasumi Takuji Iwase Hideya Tashiro Yoshihiro Fujita Hiroki Koyama Tadashi Ikeda Kiyoshi Fujiwara Keiichi Saotome Kazuaki Asaishi Rikiya Abe Mitsuhiro Nihei Tsunehiro Ishida Takao Yokoe Hiroshi Yamamoto Motoi Murata 《Breast cancer research and treatment》1992,24(1):51-59
Summary To study the effects of family history and reproductive, anthropometric, and dietary factors on the risk of breast cancer among low risk populations, we conducted a hospital-based case-control study involving 908 patients with breast cancer and their matched controls, in Japan. A positive family history of breast cancer significantly increased the risk of breast cancer (odds ratio = 1.52, 95% confidence interval: 1.14–2.03). The risk further increased with increasing number of family members affected. Obesity, single marital status, fewer births, a late childbirth, and less consumption of green-yellow vegetables and dairy products were also associated with an increased risk of breast cancer. These associations were independent in multivariate analyses. There was no increase in risk associated with consumption of high fat foods. When analyzed by menopausal status, the association with family history of breast cancer, especially in the first degree of relatives, was more evident for premenopausal breast cancer. The associations with obesity and lower consumption of dairy products were more pronounced for postmenopausal breast cancer, while those with lower parity and single marital status were stronger for premenopausal breast cancer. 相似文献
8.
M Nasu H Fujiwara J Sono Y Okada S Miyamoto S Nishiuchi K Tatemichi T Shomura 《The Journal of cardiovascular surgery》1990,31(6):809-811
Annulo-aortic ectasia is an extremely rare complication of Gaucher's disease. We report successful surgery in a patient with Gaucher's disease complicated by annulo-aortic ectasia and aortic dissection. Cabrol's operation was accomplished without bleeding or sternal adaptation problems. 相似文献
9.
By use of a double-labeling immunofluorescence method with a confocal laser scanning microscope, we have examined whether a calcium-binding protein, calretinin, is localized in magnocellular oxytocin and vasopressin neurons of the rat hypothalamus. In the supraoptic nucleus, all oxytocin-labeled cells were stained for calretinin. However, in the magnocellular part of the paraventricular nucleus, almost all oxytocin-stained cells were devoid of calretinin immunoreactivity. All vasopressin-positive cells of both the supraoptic nucleus and the magnocellular part of the paraventricular nucleus lacked calretinin immunoreactivity. No calretinin immunoreactivity was found in oxytocin-labeled cells of the the anterior commissural nucleus or in vasopressin-labeled cells of the suprachiasmatic nucleus. We previously showed that another calcium-binding protein, calbindin-D28k, was localized in magnocellular oxytocin neurons of the supraoptic nucleus but not in those of the paraventricular nucleus. These findings suggest that, in general, magnocellular oxytocin neurons of the supraoptic nucleus and those of the paraventricular nucleus can be chemically distinguished, that is, the former contain both calretinin and calbindin-D28k but the latter lack the two calcium-binding proteins. 相似文献
10.
Masami Yoshida Hideyasu Yokoo Kimihiro Nakahara Masaru Tomita Naoyuki Hamada Michiko Ishikawa Jyunko Hatakeyama Masatoshi Tanaka Ikuko Nagatsu 《Brain research》1997,767(2):87
Infusion of muscimol (5×10−5 M, 60 min) into the nucleus accumbens (NAC) through a dialysis membrane caused a significant increase in extracellular dopamine (DA) and its metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC). Fos-like immunoreactivity induced by intra-NAC infusion of muscimol was seen ipsilaterally in many accumbofugal target areas, but no Fos-positive neurons were seen in the vicinity of the dialysis membrane in the NAC. Sequential staining of Fos and tyrosine hydroxylase (TH) immunoreactivities revealed that a portion of A10 dopaminergic neurons were double-labelled. These results suggest that muscimol in the NAC disinhibits mesolimbic DA neuronal activity possibly through activity of the accumbofugal GABA neuron system. 相似文献