全文获取类型
收费全文 | 1125篇 |
免费 | 57篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 47篇 |
妇产科学 | 11篇 |
基础医学 | 94篇 |
口腔科学 | 12篇 |
临床医学 | 96篇 |
内科学 | 163篇 |
皮肤病学 | 7篇 |
神经病学 | 60篇 |
特种医学 | 81篇 |
外科学 | 257篇 |
综合类 | 53篇 |
一般理论 | 1篇 |
预防医学 | 79篇 |
眼科学 | 27篇 |
药学 | 58篇 |
肿瘤学 | 141篇 |
出版年
2022年 | 7篇 |
2021年 | 20篇 |
2020年 | 11篇 |
2019年 | 22篇 |
2018年 | 23篇 |
2017年 | 13篇 |
2016年 | 10篇 |
2015年 | 28篇 |
2014年 | 25篇 |
2013年 | 70篇 |
2012年 | 67篇 |
2011年 | 60篇 |
2010年 | 48篇 |
2009年 | 50篇 |
2008年 | 50篇 |
2007年 | 45篇 |
2006年 | 40篇 |
2005年 | 46篇 |
2004年 | 33篇 |
2003年 | 39篇 |
2002年 | 23篇 |
2001年 | 29篇 |
2000年 | 22篇 |
1999年 | 33篇 |
1998年 | 26篇 |
1997年 | 26篇 |
1996年 | 26篇 |
1995年 | 18篇 |
1994年 | 18篇 |
1993年 | 10篇 |
1992年 | 15篇 |
1991年 | 14篇 |
1990年 | 18篇 |
1989年 | 15篇 |
1988年 | 21篇 |
1987年 | 19篇 |
1986年 | 16篇 |
1985年 | 17篇 |
1984年 | 17篇 |
1983年 | 8篇 |
1982年 | 7篇 |
1981年 | 11篇 |
1980年 | 6篇 |
1979年 | 6篇 |
1977年 | 8篇 |
1976年 | 10篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1941年 | 3篇 |
1932年 | 4篇 |
排序方式: 共有1191条查询结果,搜索用时 15 毫秒
1.
Robotic-assisted heller myotomy versus laparoscopic heller myotomy for the treatment of esophageal achalasia: multicenter study 总被引:3,自引:0,他引:3
Santiago Horgan M.D. Carlos Galvani M.D. Maria V. Gorodner M.D. Pablo Omelanczuck M.D. Fernando Elli M.D. Federico Moser M.D. Luis Durand M.D. Miguel Caracoche M.D. Jorge Nefa M.D. Sergio Bustos M.D. Phillip Donahue M.D. Pedro Ferraina M.D. 《Journal of gastrointestinal surgery》2005,9(8):1020-1030
Laparoscopic Heller myotomy (LHM) has become the standard treatment option for achalasia. The incidence of esophageal perforation
reported is about 5%–10%. Robotically assisted Heller myotomy (RAHM) is emerging as a safe alternative to LHM. Data comparing
the two approaches are scant. The aim of this study was to compare RAHM with LHM in terms of efficacy and safety for treatment
of achalasia. A total of 121 patients underwent surgical treatment of achalasia at three institutions. A retrospective review
of prospectively collected perioperative data was performed. Patients were divided into two groups: group A (RAHM), 59 patients,
and group B (LHM), 62 patients. All the operations were completed using minimally invasive techniques. There were 63 women
and 58 men, with a mean age of 45 ±19 years (14–82 years). Fifty-one percent of patients in group A and 95% of patients in
group B reported weight loss. Duration of symptoms was equal for both groups. Dysphagia was the main complaint in both groups
(P = NS). There was no difference in preoperative endoscopic treatment in both groups (44% versus 27%, P = NS). Operative
time was significantly shorter for LHM in the first half of the experience (141 ± 49 versus 122 ± 44 minutes, P < .05). However,
in the last 30 cases there was no difference in operative time between the groups (P = NS). Intraoperative complications (esophageal
perforation) were more frequent in group B (16% versus 0%). The incidence of postoperative heartburn did not differ by group.
There were no deaths. At 18 and 22 months, 92% and 90% of patients had relief of their dysphagia. This study suggests that
RAHM is safer than LHM, because it decreases the incidence of esophageal perforation to 0%, even in patients who had previous
treatment. At short-term follow-up, relief of dysphagia was equally achieved in both groups.
Presented at the Forty-Sixth Annual Meeting of The Society for Surgery of the Alimentary Tract, Chicago, Illinois, May 14–18,
2005 (oral presentation).
This study was supported in part by a grant provided by Intuitive Surgical, Inc. and Ethicon Endo-Surgery, Inc. 相似文献
2.
3.
4.
5.
G. P. Sadler S. McGee N. S. Dallimore I. J. Monypenny A. G. Douglas-Jones Mr K. Lyons K. Horgan 《The British journal of surgery》1994,81(9):1315-1317
Fine-needle aspiration cytology (FNAC) plays a key role in the preoperative diagnosis of carcinoma of the breast but is less reliable in the diagnosis of infiltrating lobular carcinoma. The method of diagnosis was reviewed in 56 patients with lobular carcinoma who had attended screening and symptomatic clinics. In 29 patients FNAC results demonstrated malignant cells; 15 of these had palpable disease and the mean tumour size was 21 mm. In 27 patients FNAC failed to demonstrate malignant cells; 13 lesions were palpable and the mean tumour size was 23 mm. Ten patients were diagnosed by needle-core biopsy when FNAC was not diagnostic. FNAC may fail to diagnose even large lobular carcinoma and needle-core biopsy is strongly recommended in this situation. 相似文献
6.
Brandon JC; Teplick SK; Haskin PH; Sammon JK; Muhr WF; Hofmann AF; Gambescia RA; Zitomer N 《Radiology》1988,166(3):665-667
The authors describe their experience with methyl tertiary butyl ether (MTBE) in a larger series of patients than previously reported in order to acquaint physicians with both its effectiveness for dissolution of common bile duct calculi and the limitations of its use. Ten patients with 13 biliary calculi underwent percutaneous stone dissolution treatment with the experimental cholesterol solvent, MTBE. Three stones completely dissolved within 30 minutes, seven were reduced in size, and three were visibly unaffected. All stones not completely dissolved were easily extracted by means of a stone basket except for one in a patient taken to surgery. Although MTBE perfusion is an effective technique for management of biliary calculi, practitioners should be aware that its use is quite time consuming and its odor difficult to control. 相似文献
7.
8.
E A Wanek J G Horgan F M Karrer R J Hall C M Rumack J R Lilly 《Journal of pediatric surgery》1990,25(1):146-148
From December 1986 to April 1989, 38 patients with biliary atresia (eight newly diagnosed) were evaluated with doppler ultrasound of the portal venous system. Peak and mean velocities were computer derived from the spectral waveform. Good velocity was greater than 15 cm/s, intermediate velocity was 8 to 14 cm/s, abnormal velocity was less than 7 cm/s or hepatofugal. Patients were grouped according to clinical status: group 1 (n = 14), normal liver function; group 2 (n = 15), recurrent cholangitis; group 3 (n = 2), established bile drainage but complicated cirrhosis; group 4 (n = 7), failed portoenterostomy. All patients with normal liver function (group 1) had good or intermediate velocities. Thirteen of 15 patients with recurrent cholangitis (group 2) had good or intermediate velocities. Both patients in this group with abnormal velocities required transplantation. In group 3 the patient with abnormal velocity is on the transplant waiting list. In group 4, abnormal velocities preceded or coincided with deterioration of liver function in five of seven patients. Doppler ultrasound provides useful anatomic information, determines direction of flow, quantitates velocity of flow, and, when performed serially, provides adjunctive information on liver status in children with biliary atresia. These preliminary results suggest that patients with abnormal or significantly decreasing velocity are destined for transplantation. Patients with good portal venous velocity warrant ongoing, aggressive surgical management. 相似文献
9.
Para-ileostomy hernia: failure of a local repair technique 总被引:3,自引:0,他引:3
Different techniques of local repair of para-ileostomy herniae have been recommended by a number of authors, but without report of long-term outcome. Two patients presenting electively with symptomatic para-ileostomy herniae are reported. A local repair technique was used in each case because of severe (coexisting) medical disease, but both herniae recurred within 2 years. It is considered that local repair without stomal transposition cannot be recommended. The literature is reviewed. 相似文献
10.
Darai E; Leblanc M; Walker-Combrouze F; Bringuier AF; Madelenat P; Scoazec JY 《Human reproduction (Oxford, England)》1998,13(5):1346-1352
We evaluated the immunohistochemical expression of cadherins and CD44
variants in 20 endometriomas, 20 cystadenomas, 20 borderline ovarian
tumours as well as 20 ovarian carcinomas, and the serological and cystic
fluid concentrations of soluble E-cadherin and soluble CD44 standard
(sCD44sdt) in 20 endometriomas, 20 cystadenomas, six borderline and 11
carcinomas of the ovary. In endometriomas, immunostaining of E- and
N-cadherin was negative (20 and 30% respectively). CD44 H, v3 and v6
immunostaining were detected in 63, 10 and 40% respectively. A difference
in immunostaining for E-cadherin was found between endometriomas and
cystadenomas (P < 0.001) and for N- cadherin between endometriomas and
carcinomas (P < 0.001). A difference in CD44H immunostaining was
observed between endometriomas and cystadenomas (P < 0.035) but not with
borderline ovarian tumours and carcinomas. No difference in serum
concentrations of soluble E- cadherins and CD44 standard was found between
the four groups of tumours. Cystic fluid concentrations of E-cadherin were
lower in endometriomas than in borderline tumours and ovarian carcinomas (P
< 0.001). High concentrations of soluble CD44 standard cystic fluid were
found in endometriomas than in other ovarian cysts. Endometriomas and
borderline tumours share alterations of cadherins and CD44 isoforms which
may help in the understanding of the aggressive and invasive potentials of
endometriotic cells.
相似文献