全文获取类型
收费全文 | 1584篇 |
免费 | 93篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 77篇 |
妇产科学 | 15篇 |
基础医学 | 150篇 |
口腔科学 | 73篇 |
临床医学 | 196篇 |
内科学 | 432篇 |
皮肤病学 | 18篇 |
神经病学 | 70篇 |
特种医学 | 267篇 |
外科学 | 142篇 |
综合类 | 34篇 |
预防医学 | 46篇 |
眼科学 | 16篇 |
药学 | 66篇 |
中国医学 | 5篇 |
肿瘤学 | 60篇 |
出版年
2023年 | 8篇 |
2021年 | 22篇 |
2020年 | 7篇 |
2019年 | 15篇 |
2018年 | 32篇 |
2017年 | 14篇 |
2016年 | 25篇 |
2015年 | 30篇 |
2014年 | 44篇 |
2013年 | 51篇 |
2012年 | 53篇 |
2011年 | 62篇 |
2010年 | 49篇 |
2009年 | 72篇 |
2008年 | 53篇 |
2007年 | 41篇 |
2006年 | 51篇 |
2005年 | 51篇 |
2004年 | 37篇 |
2003年 | 34篇 |
2002年 | 31篇 |
2001年 | 54篇 |
2000年 | 44篇 |
1999年 | 31篇 |
1998年 | 58篇 |
1997年 | 65篇 |
1996年 | 67篇 |
1995年 | 52篇 |
1994年 | 48篇 |
1993年 | 47篇 |
1992年 | 29篇 |
1991年 | 14篇 |
1990年 | 19篇 |
1989年 | 37篇 |
1988年 | 32篇 |
1987年 | 39篇 |
1986年 | 36篇 |
1985年 | 27篇 |
1984年 | 20篇 |
1983年 | 16篇 |
1982年 | 27篇 |
1981年 | 16篇 |
1980年 | 8篇 |
1979年 | 7篇 |
1978年 | 11篇 |
1977年 | 16篇 |
1976年 | 14篇 |
1975年 | 20篇 |
1974年 | 7篇 |
1971年 | 6篇 |
排序方式: 共有1685条查询结果,搜索用时 625 毫秒
1.
ME BURGE AM JOSHUA CM McNEIL R HUI MJ BOYER R ABRAHAM 《Asia-Pacific Journal of Clinical Oncology》2005,1(1):47-52
Background: Pemetrexed and cisplatin have recently been shown to significantly improve survival compared with cisplatin alone. However, there are only limited data reflecting teaching hospital experience outside a clinical trial. Pemetrexed has only been available in Australia on a restricted basis since 2002. We reviewed our experience of patients treated on the Australian ‘Special Access Scheme’ at three major thoracic oncology units. Methods: Charts were reviewed for all patients enrolled on the scheme. Data was extracted on age, World Health Organization (WHO) performance status, histology, prior therapy, time from diagnosis to starting pemetrexed, chemotherapy (pemetrexed alone or with a platinum), cycle number, response rate, actuarial progression‐free and overall survival. Doses were cisplatin 75 mg/m2 or carboplatin AUC = 5 and pemetrexed 500 mg/m2 every 21 days. Results: 52 patients (32 male and 20 female) were reviewed. Median age was 58 years and 88% were WHO 0–1. Histology included 54% epithelial, 17% biphasic (epithelial and sarcomatoid) and 21% undefined. The median time from diagnosis to administration of pemetrexed was 145 days. Sixty‐five percent had minimal surgical intervention with video assisted thoracoscopy, pleurodesis and biopsy, while 19% had received prior palliative radiation. Seventy‐one percent were chemotherapy naïve, the remaining 29% having received previous platinum and/or gemcitabine regimens. Twenty‐three percent had pemetrexed alone, 35% in combination with carboplatin and 42% with cisplatin. The median number of cycles was 4 (range 1–13). The response rate was 33%. No toxicity was observed in 20% grade 3–4 toxicity in 10% (majority nausea/vomiting). The median progression‐free and overall survival times from starting pemetrexed were 184 days and 298 days, respectively. Conclusions: Pemetrexed‐based regimens are safe and effective in a community setting in malignant mesothelioma. 相似文献
2.
A review of the related literature revealed ambiguity and inconsistency as to the location of the first and most medial deep transverse metatarsal ligament in relation to the adjacent soft tissue and osseous structures. Seventy right sided, mid-thigh cadaveric dissections were completed by the investigators. The results consistently identified the ligament as bifurcate, bearing a common stem with the medial aspect of the second metatarsophalangeal joint capsule and a split attachment to the lateral aspect of the first metatarsophalangeal joint capsule and sesamoidal apparatus. The conjoined tendon of the adductor hallucis muscle was consistently identified as passing between this bifurcation. Knowledge of the location of this anatomic structure bears importance in the podiatric surgeon's attempt to restore the alignment of the first metatarsophalangeal joint by means of soft tissue or osseous procedures. 相似文献
3.
4.
5.
6.
7.
8.
9.
10.
Jason N. MacLean Brian J. Schmidt Shawn Hochman 《The European journal of neuroscience》1997,9(12):2702-2711
Whole-cell recordings of lumbar motoneurons in the intact neonatal rat spinal cord in vitro were undertaken to examine the effects of Kmethyl-D-aspartate (NMDA) receptor activation on membrane behaviour. Bath application of NMDA induced rhythmic voltage oscillations of 5.9 ± 2.1 mV (SD) at a frequency of 4.4 ± 1.5 Hz. Amplitude, but not frequency, of the voltage oscillations was membrane potential-dependent. Voltage oscillations could recruit action potentials and/or plateau potentials with or without superimposed bursting. Blockade of synaptic transmission with tetrodotoxin (TTX) sometimes resulted in a loss of oscillatory activity which could then be restored by increasing the NMDA concentration. After application of TTX, the trajectory of NMDA-induced oscillations was similar to the trajectory induced in the presence of intact synaptic networks, although the mean oscillation duration was longer and the oscillation frequency was slower (1.8 ± 1.1 Hz). Current ramps delivered after bath application of NMDA demonstrated bistable membrane properties which may underlie the plateau potentials. Injection of intracellular current pulses could initiate, entrain and terminate individual plateau potentials. The results suggest that membrane depolarization produced by oscillations may activate other intrinsic conductances which generate plateau potentials, thereby providing the neuron with enhanced voltage sensitivity, compared to that produced by NMDA receptor activation alone. These oscillatory events may have a role in the regulation of motor output in a variety of rhythmic behaviours including locomotion. 相似文献