全文获取类型
收费全文 | 6907篇 |
免费 | 390篇 |
国内免费 | 42篇 |
专业分类
耳鼻咽喉 | 78篇 |
儿科学 | 90篇 |
妇产科学 | 91篇 |
基础医学 | 806篇 |
口腔科学 | 189篇 |
临床医学 | 401篇 |
内科学 | 2099篇 |
皮肤病学 | 159篇 |
神经病学 | 516篇 |
特种医学 | 243篇 |
外科学 | 1247篇 |
综合类 | 29篇 |
预防医学 | 160篇 |
眼科学 | 110篇 |
药学 | 410篇 |
中国医学 | 28篇 |
肿瘤学 | 683篇 |
出版年
2023年 | 30篇 |
2022年 | 53篇 |
2021年 | 132篇 |
2020年 | 85篇 |
2019年 | 98篇 |
2018年 | 142篇 |
2017年 | 113篇 |
2016年 | 146篇 |
2015年 | 157篇 |
2014年 | 174篇 |
2013年 | 203篇 |
2012年 | 394篇 |
2011年 | 429篇 |
2010年 | 230篇 |
2009年 | 215篇 |
2008年 | 360篇 |
2007年 | 396篇 |
2006年 | 373篇 |
2005年 | 385篇 |
2004年 | 387篇 |
2003年 | 434篇 |
2002年 | 418篇 |
2001年 | 139篇 |
2000年 | 128篇 |
1999年 | 154篇 |
1998年 | 111篇 |
1997年 | 72篇 |
1996年 | 82篇 |
1995年 | 54篇 |
1994年 | 77篇 |
1993年 | 56篇 |
1992年 | 127篇 |
1991年 | 94篇 |
1990年 | 94篇 |
1989年 | 75篇 |
1988年 | 79篇 |
1987年 | 80篇 |
1986年 | 62篇 |
1985年 | 68篇 |
1984年 | 53篇 |
1983年 | 35篇 |
1982年 | 36篇 |
1981年 | 43篇 |
1980年 | 22篇 |
1979年 | 42篇 |
1977年 | 23篇 |
1974年 | 15篇 |
1972年 | 15篇 |
1971年 | 18篇 |
1968年 | 15篇 |
排序方式: 共有7339条查询结果,搜索用时 15 毫秒
1.
Chie Teramoto PHN RN MS Satoko Nagata PhD PHN RN Reiko Okamoto PhD PHN RN Ruriko Suzuki PHN RN MS Emiko Kishi PhD PHN RN Michie Nomura DSN PHN RN Noriko Jojima PHN RN MS Masumi Nishida PhD PHN RN Keiko Koide PhD PHN RN Emiko Kusano PhD PHN RN Saori Iwamoto PhD PHN RN Sachiyo Murashima PhD PHN RN 《Public health nursing (Boston, Mass.)》2015,32(6):654-661
2.
3.
4.
Shinji Naganawa Rintaro Ito Hisashi Kawai Toshiaki Taoka Tadao Yoshida Michihiko Sone 《Magnetic resonance in medical sciences》2020,19(4):375
Purpose:It has been reported previously that intravenously administered gadolinium-based contrast agent (GBCA) leaks into the subarachnoid space around the cortical veins at 4 h after injection in all old people over 37 years, but not in younger people up to 37 years of age in 3D-real IR images. The purpose of this study was to investigate whether there was a strict threshold of 37 years of age for the leakage of the GBCA into the subarachnoid space.Methods:The subjects included 190 patients, that were scanned for 3D-real IR images at 4 hours after intravenous injection of GBCA as a diagnostic test for endolymphatic hydrops. The patient’s age ranged from 14 to 81 years. Two experienced neuroradiologists evaluated the images to determine whether the GBCA leakage around the cortical veins was positive or negative. Any discrepancies between the two observers were discussed and a consensus was obtained.A Mann–Whitney U test and receiver operating characteristic (ROC) curve analysis were used to compare the positive and the negative group and to set the age cut-off value for the prediction of GBCA leakage.Results:The GBCA leakage around the cortical veins was negative in 35 patients and positive in 155 patients. The average age was 33 ± 11 years in the negative group, and 55 ± 12 years in the positive group (P < 0.01). In the ROC analysis for the age and leakage of the GBCA, an area under the curve was 0.905 and the cut-off age was 37.317 years (sensitivity of 0.942 and specificity of 0.771).Conclusion:Intravenously administered GBCA leaks into the subarachnoid space around the cortical veins in most patients over 37 years of age. However, it should be noted that it can be found occasionally in patients under 37 years of age. 相似文献
5.
6.
Two-color flow cytometry was carried out to determine the correlation between cell-mediated immunity and the levels of proteinuria in 30 patients with membranous nephropathy. Lymphocyte subpopulations were measured by two-color flow cytometry using various monoclonal antibodies of the Leu series. Clinically, the patients were divided into four stages as follows: 1. untreated nephrotic stage, 2. prednisolone (PSL) treated nephrotic stage, 3. persistent proteinuric stage (incomplete remission, ICR) and 4. complete remission (CR). Two-color flow cytometry showed a significant decrease in Leu 2a+15+ (suppressor T) cells and relative increase in Leu 3a+8+ (suppressor inducer T) cells in the untreated nephrotic stage. The mean Leu 3a+8-/Leu 2a+15+ (helper/suppressor) cell ratio was normalized in the persistent proteinuric stage or complete remission after treatment with PSL. Patients with membranous nephropathy showed a significant elevation of Leu 2a+DR+ cells after treatment with PSL. The abnormalities of suppressor T cells and suppressor inducer T cells in the peripheral blood appear to reflect the levels of proteinuria in patients with membranous nephropathy. It was concluded that PSL might stimulate Leu 2a positive cells and then increase the number of Leu 2a+15+ cells in the peripheral blood of patients with membranous nephropathy. 相似文献
7.
I Maeda T Ueda R Koide M Inatomi Y Fukado E Uchida K Oguchi H Yasuhara 《Japanese journal of ophthalmology》1988,32(2):211-218
The effects of monoamine oxidase-A (MAO-A) inhibitors with epinephrine on intraocular pressure in the pigmented rabbit were studied. MAO-A inhibitors were used topically with or without various concentrations of epinephrine. For the measurement of intraocular pressure, applanation pneumatonography was used and tissue MAO activities were determined by radiometric assay. After topical administration with clorgyline, MAO-A activities in the bulbar conjunctiva and the iris-ciliary body were remarkably inhibited, whereas MAO-B inhibition was minimal. Maximal reduction of intraocular pressure with 0.05% epinephrine was 3.2 mmHg. Single administration of clorgyline, amiflamine, moclobemide or CGP 11305-A caused decreases in the intraocular pressure of 2.0, 2.5, 1.8 and 2.4 mmHg, respectively. In the coadministration experiments with epinephrine, the ocular hypotensive effects of epinephrine were potentiated with clorgyline, amiflamine, moclobemide and CGP 11305-A (6.6, 4.8, 5.6 and 5.8 mmHg). On the contrary, they were not influenced by the MAO-B inhibitor deprenyl. These results indicated that MAO-A inhibitors potentiated the ocular hypotensive effects of epinephrine, and that the coadministration of a reversible MAO-A inhibitor with epinephrine might be useful for patients with glaucoma. 相似文献
8.
9.
Eri Inoue-Matsuhisa Sayoko E Moroi Hisashi Takenaka Shunji Sogo Tomiya Mano 《Journal of ocular pharmacology and therapeutics》2003,19(1):55-62
The serotonin 2 (5-HT(2)) receptor antagonists, MCI-9042 (Anplag) and ketanserin, have been shown to lower intraocular pressure in rabbits (1) and humans (2). The mechanism of action of these drugs has not been determined, but it is hypothesized that 5-HT(2) receptors, and possibly alpha-adrenergic receptors, (3) may regulate in part aqueous humor production via an intracellular signal transduction pathway in the ciliary body. We therefore examined whether 5-HT(2) receptors were coupled to phosphoinositide hydrolysis in an organ culture system of isolated bovine ciliary epithelium. 5-HT stimulated [(3)H]inositol phosphates ([(3)H]InsPs) accumulation in a dose-dependent manner with a maximum increase approximately twice over the basal level. The mean EC(50) value was 1.1 microM, which was calculated from four dose-response curves. The 5-HT stimulated accumulation of [(3)H]InsPs was inhibited by spiperone (5-HT(2A/1A) and dopamine 2 (D(2)) antagonists), M-1 (a major metabolite of MCI-9042), ketanserin (5-HT(2A) antagonist), SB-206553 (5- HT(2B/2C) antagonist), and mesulergine (5-HT(2C) antagonist and D(2) agonist). It was not inhibited by chlorpromazine, which is a D(2) receptor antagonist. Accordingly, our study demonstrates that 5-HT(2) receptors are coupled to phospholipase C in bovine ciliary epithelium. 相似文献
10.