全文获取类型
收费全文 | 1442篇 |
免费 | 58篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 10篇 |
妇产科学 | 14篇 |
基础医学 | 119篇 |
口腔科学 | 78篇 |
临床医学 | 93篇 |
内科学 | 357篇 |
皮肤病学 | 12篇 |
神经病学 | 53篇 |
特种医学 | 65篇 |
外科学 | 326篇 |
综合类 | 4篇 |
预防医学 | 43篇 |
眼科学 | 8篇 |
药学 | 48篇 |
中国医学 | 4篇 |
肿瘤学 | 233篇 |
出版年
2023年 | 15篇 |
2022年 | 17篇 |
2021年 | 60篇 |
2020年 | 17篇 |
2019年 | 25篇 |
2018年 | 45篇 |
2017年 | 24篇 |
2016年 | 42篇 |
2015年 | 43篇 |
2014年 | 52篇 |
2013年 | 58篇 |
2012年 | 99篇 |
2011年 | 109篇 |
2010年 | 54篇 |
2009年 | 45篇 |
2008年 | 83篇 |
2007年 | 77篇 |
2006年 | 66篇 |
2005年 | 77篇 |
2004年 | 89篇 |
2003年 | 68篇 |
2002年 | 92篇 |
2001年 | 11篇 |
2000年 | 11篇 |
1999年 | 19篇 |
1998年 | 19篇 |
1997年 | 14篇 |
1996年 | 9篇 |
1995年 | 13篇 |
1994年 | 10篇 |
1993年 | 8篇 |
1992年 | 12篇 |
1991年 | 12篇 |
1990年 | 9篇 |
1989年 | 4篇 |
1985年 | 4篇 |
1981年 | 5篇 |
1978年 | 4篇 |
1977年 | 11篇 |
1976年 | 6篇 |
1974年 | 4篇 |
1973年 | 6篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1970年 | 6篇 |
1969年 | 5篇 |
1968年 | 5篇 |
1967年 | 4篇 |
1966年 | 5篇 |
1962年 | 3篇 |
排序方式: 共有1507条查询结果,搜索用时 15 毫秒
1.
This retrospective study aimed to evaluate radiation-induced pneumonitis (RIP) and a related condition that we define in this report—prolonged minimal RIP (pmRIP)—after stereotactic body radiotherapy (SBRT) for Stage I primary lung cancer in patients with chronic obstructive pulmonary disease (COPD). We assessed 136 Stage I lung cancer patients with COPD who underwent SBRT. Airflow limitation on spirometry was classified into four Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades, with minor modifications: GOLD 1 (mild), GOLD 2 (moderate), GOLD 3 (severe) and GOLD 4 (very severe). On this basis, we defined two subgroups: COPD-free (COPD −) and COPD-positive (COPD +). There was no significant difference in overall survival or cause-specific–survival between these groups. Of the 136 patients, 44 (32%) had pmRIP. Multivariate analysis showed that COPD and the Brinkman index were statistically significant risk factors for the development of pmRIP. COPD and the Brinkman index were predictive factors for pmRIP, although our findings also indicate that SBRT can be tolerated in early lung cancer patients with COPD. 相似文献
2.
3.
Byonggu An Yumi Zen Hiroya Akabori Naomi Kitamura Hiroyuki Ohta Akinori Otsuki Hiroo Mizuta Tomoyuki Tsujikawa Eiji Mekata 《Asian journal of endoscopic surgery》2021,14(1):120-123
A Bochdalek hernia (BH) is a congenital abnormality with incomplete closure of the diaphragm. It is usually manifested in infants but rarely in adults. Here, we report an adult patient with gastric volvulus and giant BH that were safely repaired by endoscopic reduction and elective laparoscopic surgery, respectively. A 79-year-old woman presented with left upper abdominal pain but no history of trauma. CT revealed a giant BH with gastric volvulus. After emergency endoscopic reduction of the volvulus, elective laparoscopic repair of the BH was performed. The 8 × 8-cm defect was repaired with interrupted nonabsorbable sutures and a mesh. The patient's postoperative course was uneventful, and no complications or recurrence were observed in the 6 months that followed. 相似文献
4.
Takanori Kikuchi Naoshi Fukui Tomohiro Sakuta Toshijiro Yamaguchi Hiroya Sakai Hiromi Oda 《Journal of orthopaedic science》1997,2(1):31-39
The midportion of the anterior cruciate ligament (ACL) of rabbits was partially transected, and the effect of hyaluronan (HA) on its healing was determined. A 1% solution of HA (HA group) or physiological phosphate-buffered saline (control group) was administered intraarticularly, at 0.1 ml/kg body weight, once a week from 1 week after the operation. Two, 4, and 6 weeks after the initiation of HA administration, the ACLs were examined grossly, histologically and immunohistochemically. At 2 weeks, the lacerated portions were completely covered with scar-like tissue in both groups. These tissue areas were smaller in the HA group than in the control group. Histologically in the HA group, the regularity of collagen fibers (indicating the maturity of regenerated collagen fibers) had increased compared to findings in the control group, and the number of fibroblastic cells decreased gradually at a significantly faster rate. The number of inflammatory cells and blood vessels decreased gradually in both groups, with these values being lower in the HA group at each time point but not significantly so. Immunohistochemical examination of the repaired tissue revealed strong staining with anti-chondroitin sulfate proteoglycan antibody in the HA group 2 weeks after the first HA administration. The staining gradually became reduced, with the rate of reduction being faster in the HA group than in the control group. The stimulation of chondroitin sulfate proteoglycan production and the faster reduction of it in the HA group suggests that HA facilitated tissue repair and inhibited the formation of scar tissue. 相似文献
5.
Dr. Yoshihiko Hayakawa Ph.D. Allan G. Farman B.D.S Ph.D. D.Sc. William C. Scarfe B.D.S M.S. Kinya Kuroyanagi D.D.S Ph.D. 《Oral Radiology》1996,12(1):11-18
The RVG-4 permits automatic exposure compensation (AEC). The purpose of this investigation was to determine the effects of
AEC on image contrast. Images were made either with or without a dental QA jaw phantom using a fixed image projection geometry.
Exposures were 6.3 through 27.3 μC/kg using an X-ray generator operated at 70 kVp. Region of interest pixel value distributions
were measured at tissue thicknesses in this phantom, and the average pixel values and signal-to-noise ratios (SNR) were calculated.
The use of AEC without an object in place resulted in a disproportionate relationship between pixel value and exposure with
a marked reduction in SNR. The use of AEC on under- and over-exposed images of the phantom simultaneously enhanced image contrast
and reduced SNR. Thus, AEC provides a convenient and quick method for achieving high-contrast images with sub-optimal exposures,
however, this could lead to inappropriate patient dosages if the function is used for over-exposed images. AEC reduces the
SNR and produces disproportionate pixel values relative to exposure. 相似文献
6.
Yoshimitsu Kuroyanagi DR. ENG DR. SCI DR. MED ; Akihiko Shiraishi MD ; Yoshiteru Shirasaki MD ; Nobuaki Nakakita MD ; Yoshiaki Yasutomi MD ; Yasuo Takano MD ; Nobuyuki Shioya MD FACS 《Wound repair and regeneration》1994,2(2):122-129
A bilaminar wound dressing composed of an outer membrane and an inner three-dimensional matrix of a fabric or a sponge may be considered to constitute an ideal structure that promotes wound healing: the outer membrane prevents body fluid loss, controls water evaporation, and protects the wound surface from bacterial invasion, and the inner matrix encourages adherence by tissue growth into the matrix. Using this concept, we developed a biosynthetic wound dressing with a drug delivery capability. This medicated wound dressing is composed of a spongy sheet of a chitosane derivative and collagen mixture that is laminated to an antimicrobial-impregnated polyurethane membrane. In this study, a gentamycin sulfate-impregnated wound dressing was prepared and evaluated. The antimicrobial efficacy of this wound dressing was examined on an agar plate seeded with Pseudomonas aeruginosa. Also, the cytotoxicity of an antimicrobial released from this wound dressing was examined in an in vitro system with cultured skin substitutes. Both in vitro tests have shown that this wound dressing is capable of suppressing bacterial growth and minimizing cellular damage. In addition, in the treatment of wounds inflicted on rats and rabbits, this wound dressing was shown to be efficacious in covering full-thickness and split-thickness skin defects. Finally, the efficacy of this wound dressing was evaluated in a nonrandomized open-label study of 31 clinical cases. In 31 cases treated with this wound dressing, good or excellent wound healing was achieved. 相似文献
7.
Multiple intracerebral hemorrhages due to cerebral amyloid angiopathy after head trauma 总被引:1,自引:0,他引:1
K Wakui K Seguchi T Kuroyanagi T Sakai Y Tanaka Y Kamijoh Z Shiozawa 《No shinkei geka. Neurological surgery》1988,16(11):1287-1291
Cerebral amyloid angiopathy (CAA) is an important cause of intracerebral hemorrhage and ischemic cerebrovascular disease in some normotensive elderly patients. The diagnosis is made by proof of amyloid deposition in the vessel wall. A case of recurrent and multiple intracerebral hemorrhages due to cerebral amyloid angiopathy after head injury is reported. A 74-year-old female was referred to our hospital because of head injury. CT scan showed traumatic subarachnoid hemorrhage and intraventricular hematoma. Her consciousness was clear but slight disorientation was recognized. Conservative therapy was performed. During the course subcortical hemorrhages occurred five times and during the second one, right frontal and right parietal hemorrhages occurred simultaneously. Her consciousness deteriorated. The second subcortical hemorrhage was especially complicated by a ventriculoperitoneal shunt operation. A biopsy of the cortex was performed and pathological examination revealed amyloid deposition in the walls of small pial and cortical vessels. Occasional duplicated wall, obliterative intimal proliferation and disappearance of elastic lamina were recognized. The patient sank into a vegetative state due to recurrent and multiple hemorrhages. CAA results in two possibilities, hemorrhage and ischemic cerebrovascular disease. When lobar or subcortical hemorrhage is encountered in a normotensive elderly patient, the possibility of a CAA-related hemorrhage should be considered. The author carefully emphasizes that there is indication for neurosurgical treatment in CAA patients and proposes that therapy for ischemic cerebrovascular disease should be given special attention. 相似文献
8.
M. Higashima Hiroya Kinoshita Nariyoshi Yamaguchi Yoshifumi Koshino 《Psychopharmacology》1997,131(4):394-398
It has been reported that the clinical and electroencephalographic profiles of zolpidem, a non-benzodiazepine drug which
binds preferentially to the ω1 benzodiazepine recognition sites located within the GABAA receptor complex, are different from those of benzodiazepine drugs, which bind non-selectively to the ω1 and ω2 sites. In order to clarify the electrophysiological mechanism underlying the unique profile of zolpidem, the present study
compared the enhancing effects of zolpidem and two benzodiazepine drugs, triazolam and diazepam, on recurrent inhibition.
This inhibition was expressed as suppression of the orthodromically induced population spikes by the preceding antidromic
stimulation of the alveus in the CA1 region of rat hippocampal slices. The rank order of potency for enhancing recurrent inhibition
was triazolam > diazepam > zolpidem. From the present results and previously reported findings that zolpidem has a lower affinity
for the ω2 sites than diazepam while both have the same affinity for the ω1 sites, we concluded that the hippocampal recurrent inhibition appears to be enhanced mainly by activation of the ω2 sites, but not by that of the ω1 sites. Furthermore, the lower potency of zolpidem for enhancing recurrent inhibition may underlie its unique profile in terms
of its clinical and electroencephalographic effects.
Received: 1 November 1996/Final version: 22 January 1997 相似文献
9.
Suzuki Hisamitsu; Ota Kazuo; Ohno Ryuzo; Masaoka Toru; Shibata Hirotoshi; Kimura Ikuro; Amaki Ichita; Miura Yasusada; Uzuka Yoshiro; Kawato Masafumi; Shirakawa Shigeru; Hirota Yutaka; Maekawa Tadashi; lmai Kuniyuki; Takaku Fumimaro; Shimoyama Masanori; Kitahara Takeshi; Oguro Masao; Kozuru Mitsuo; Kawagoe Hiroya; Nakamura Toru; Yamada Kazumasa 《Japanese journal of clinical oncology》1989,19(4):338-347
Patients with acute (2,569) and chronic (957) leukemia diagnosedat 19 institutes took part in the study on the "MultidisciplinaryTreatment of Leukemia" between 1971 and 1985 and were investigatedretrospectively. By dividing the 15 years into three five-yearperiods, we were able to compare patient ratios in the differentperiods. The proportions of acute to chronic leukemia casesshowed no obvious change; however, the proportions of casesdiagnosed as acute lymphocytic leukemia in acute leukemia showeda significant increase. The main chemotherapeutic drugs usedduring the three time periods were cytarabine or its analogues,the anthracyclines, 6-mercaputopurine and prednisolone, againstacute myelogenous leukemia, and the vinca alkaloids, prednisoloneand the anthracyclines against acute lymphocytic leukemia. Therate of complete remission from acute myelogenous leukemia mademarked progress, from 45.1% during 19711975 to 62.3%during 19811985, but that of acute lymphocytic leukemiashowed no significant progress, being 65% during 19711975and 69.7% during 19811985. The durations of remission,however, and the survival times for patients with acute lymphocyticleukemia, as well as for those with acute myelogenous leukemia,became significantly longer over the three periods. Median survivaltimes from chronic myelocytic leukemia were 3740 mo inall three periods, showing no progress. There was a better prognosisin cases of chronic myelocytic leukemia with, than without,Philadelphia chromosome. Except for a low incidence of chroniclymphocytic leukemia in Japan, adult leukemia patients' characteristicsand prognoses seem to be almost the same in Japan as in theU.S.A. and Europe. 相似文献