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排序方式: 共有213条查询结果,搜索用时 15 毫秒
1.
Hajime Kazamatsuri M.D. Tetsuya Hirose M.D. Osamu Kanno M.D. Nobumasa Kato M.D. Hiromoto Yasuda 《Psychiatry and clinical neurosciences》1994,48(4):869-879
Abstract: Two autopsied female sibling cases of sudanophilic leukodystrophy are reported. Case A and case B were the second and third of seven siblings, and a sister and a brother died from severe progressive neurological disease with similar symptoms. Consanguineous marriages were noted in the family of both cases through the past three generations. Case A gradually developed intellectual deterioration and tetraplegia at the age of 29, progressed to akinetic mutism within one year and thereafter survived for 14 years. Neuropathologically, a severe atrophy and degeneration were noted in the white matter of the whole cerebrum, sparing the subcortical U-fibers. Myelin and axons were severely damaged with peripheral astrocytic gliosis. Case B developed similar clinical symptoms at the age of 20 and survived for 7 years in the state of akinetic mutism. Similar postmortem findings as those of case A were found in the white matter of the cerebrum with formation of sudanophilic breakdown products and with thick fibrillary gliosis. The pyramidal tract was completely degenerated. There was no accumulation of abnormal lipid in the brains of both cases. 相似文献
2.
S. Lindstrom A. Endo S. Sugita M. Pecoraro Y. Hiromoto M. Kamada T. Takahashi K. Nerome 《Archives of virology》1998,143(8):1585-1598
Summary. Matrix (M) and nonstructural (NS) genes of thirteen equine H3N8 and H7N7 influenza viruses were sequenced and analyzed from
an evolutionary point of view. The M and NS genes of H3N8 viruses isolated between 1989 and 1993 evolved into two minor branch
clusters, including isolates from Europe and the American continent, respectively. It was noteworthy to reveal that the nucleotide
sequences of the M and NS genes of an earlier American strain showed highest homology to those of recent European viruses.
“Frozen evolution” was observed in the M and NS genes of A/eq/LaPlata/1/88. It was also evident that the NS gene of an H7N7
virus from 1977 was very similar to that of a 1979-H3N 8 virus, while the M gene was closest phylogenetically to that of the
earliest H7N7 virus isolated in 1956. Furthermore, the M2 protein of A/eq/Newmarket/1/77 virus contained a carboxyl terminal
deletion of three amino acids. The evolutionary rates of the M and NS genes of H3N8 equine influenza viruses were estimated
to be 5.4 × 10−4 and 5.1 × 10−4 substitutions per site per year, respectively, which were slower than those of human viruses.
Received November 21, 1997 Accepted March 9, 1998 相似文献
3.
Naoyuki Kanayama Fumiaki Isohashi Yasuo Yoshioka Sungjae Baek Masashi Chatani Tadayuki Kotsuma Eiichi Tanaka Ken Yoshida Yuji Seo Osamu Suzuki Seiji Mabuchi Yasuhiko Shiki Keiji Tatsumi Tadashi Kimura Teruki Teshima Kazuhiko Ogawa 《Journal of radiation research》2015,56(2):346-353
The purpose of this study was to determine the outcomes and optimal practice patterns of definitive radiotherapy for primary vaginal cancer. Between 1993 and 2012, 49 patients were treated with definitive radiotherapy for primary vaginal cancer in three hospitals. Of these, 15 patients (31%) had clinically positive regional lymph node metastasis. A total of 34 patients (70%) received external beam radiotherapy with high-dose-rate brachytherapy (interstitial or intracavitary), and 8 (16%) (with small superficial Stage I tumors) were treated with local radiotherapy. The median follow-up was 33 months (range: 1–169 months). The 3-year overall survival (OS), disease-free survival (DFS), and loco-regional control (LRC) rates were 83%, 59% and 71%, respectively. In multivariate analysis, the histological type (P = 0.044) was significant risk factors for LRC. In Federation of Gynecology and Obstetrics (FIGO) Stage I cases, 3 of 8 patients (38%) who did not undergo prophylactic lymph node irradiation had lymph node recurrence, compared with 2 of 12 patients (17%) who underwent prophylactic pelvic irradiation. For Stage III–IV tumors, the local recurrence rate was 50% and the lymph node recurrence rate was 40%. Patients with FIGO Stage I/II or clinical Stage N1 had a higher recurrence rate with treatment using a single modality compared with the recurrence rate using combined modalities. In conclusion, our treatment outcomes for vaginal cancer were acceptable, but external beam radiotherapy with brachytherapy (interstitial or intracavitary) was needed regardless of FIGO stage. Improvement of treatment outcomes in cases of FIGO Stage III or IV remains a significant challenge. 相似文献
4.
Although there are various treatments for postherpetic neuralgia (PHN), none produces definitive effects. We report a case of 72-year-old woman who developed intractable PHN of the chest in which treatment with endoscopic transthoracic sympathicotomy (ETS) produced long-term effective results. When hyperesthesia of the sympathetic nerve participates in PHN, the blocking of sympathetic excitation seems to be effective for PHN suppression. The method using a single resectoscope is safe, accurate, yields excellent results cosmetically, and generates minimal invasion and very little postoperative pain. Although ETS is not always effective for all cases of PHN, it could be a useful method of treating patients with PHN that is resistant to conventional therapies. 相似文献
5.
Takanao Mine M.D. Ph.D. Hiroki Shimizu M.D. Ph.D. Kenji Hiromoto M.D. Ph.D. Yoshio Furukawa M.D. Tetsuzou Kanemori M.D. Hiroaki Nakamura M.D. Tohru Masuyama M.D. Ph.D. Mitsumasa Ohyanagi M.D. Ph.D. 《Annals of noninvasive electrocardiology》2008,13(3):228-233
Background : Beat‐to‐beat QT interval variability is associated with life‐threatening arrhythmias and sudden death, however, its precious mechanism and the autonomic modulation on it remains unclear. The purpose of this study was to determine the effect of drugs that modulate the autonomic nervous system on beat‐to‐beat QT interval. Method : RR and QT intervals were determined for 512 consecutive beats during fixed atrial pacing with and without propranolol and automatic blockade (propranolol plus atropine) in 11 patients without structural heart disease. Studied parameters included: RR, QTpeak (QRS onset to the peak of T wave), QTend (QRS onset to the end of T wave) interval, standard deviation (SD) of the RR, QTpeak, and QTend (RR‐SD, QTpeak‐SD, and QTend‐SD), coefficients of variation (RR‐ CV, QTpeak‐CV, and QTend‐CV) from time domain analysis, total power (TP; RR‐TP, QTpeak‐TP, and QTend‐TP), and power spectral density of the low‐frequency band (LF; RR‐LF, QTpeak‐LF, and QTend‐LF) and the high‐frequency band (HF; RR‐HF, QTpeak‐HF and QTend‐HF). Results : Administration of propranolol and infusion of atropine resulted in the reduction of SD, CV, TP, and HF of the QTend interval when compared to controlled atrial pacing (3.7 ± 0.6 and 3.5 ± 0.5 vs 4.8 ± 1.4 ms, 0.9 ± 0.1 and 0.9 ± 0.1 vs 1.2 ± 0.3%, 7.0 ± 2.2 and 7.0 ± 2.2 vs 13.4 ± 8.1 ms2, 4.2 ± 1.4 and 4.2 ± 1.2 vs 8.4 ± 4.9 ms2, respectively). Administration of propranolol and atropine did not affect RR interval or QTpeak interval indices during controlled atrial pacing. Conclusions : Beat‐to‐beat QT interval variability is affected by drugs that modulate the autonomic nervous system. 相似文献
6.
On the diagnosis of backache, at first ask patients detailed questions about medical history of backache, the situation at the time of onset and process of the pain, intensity and location on the body of the pain, which movement to strengthen them or which posture to moderate them. Following them, check the abnormality of how to walk and the normal curvature of the spine at standing from behind and the side. Examine the movement and flexibility of the lumbar spine in bending forward, backward and twisting. After them, examine the neurological functions on their legs to search paralysis, muscle weakness, reflex changes and sensory changes. Observe lumbar part and check the presence of redness, swelling and hyperthermia, and examine a location of tenderness. X-rays, CT or MRI examination can be performed if necessary, but should not be fascinated by only image findings, and it is necessary to evaluate in total them with the results of physical examinations. 相似文献
7.
Shinji Uesaka Kyosuke Miyazaki Hiromoto Ito 《Modern rheumatology / the Japan Rheumatism Association》2004,14(6):470-475
The effects of factors such as age and sex on the metabolism of chondroitin sulfate (CS) and hyaluronic acid (HA) in knee
joint tissues are believed to be profoundly important in the onset of joint diseases including osteoarthritis. To test whether
age and sex influence CS isomers and HA in normal synovial fluid, we determined concentrations of chondroitin 6-sulfate (C6S),
chondroitin 4-sulfate (C4S), and HA in healthy subjects of different ages. Synovial fluids were obtained from 187 healthy
volunteers, 14–89 years of age. Chondroitin 6-sulfate, C4S, HA concentrations, and C6S : C4S ratio showed a significant negative
correlation with age. There were no sex-related differences in HA concentration, but the concentrations of C6S and C4S and
the C6S : C4S ratio were significantly lower in women than in men in most age groups. 相似文献
8.
Yoshihiro Sudo Yoichi Ezura Ryota Ishida Mitsuko Kajita Hideyo Yoshida Takao Suzuki Takayuki Hosoi Satoshi Inoue Masataka Shiraki Hajime Orimo Hiromoto Ito Mitsuru Emi 《Geriatrics & Gerontology International》2004,4(4):245-249
Background: Osteoporosis is believed to result from the interaction among multiple environmental and genetic determinants that regulate bone-mineral density (BMD).
Methods: To investigate a potentially predisposing genetic factor in the onset of osteoporosis, we looked for a possible association between BMD in adult Japanese women and known polymorphisms in the leukemia inhibitory factor receptor gene (LIFR).
Results: An association analysis of chromosomes from 384 volunteer subjects revealed significant correlation between the −603T > C variant of LIFR and radial BMD ( r = 0.11, P = 0.032) in this test population. Comparisons of mean values of adjusted radial BMD among separate genotypic groups implied an allelic dosage effect, because homozygous carriers of T alleles of that SNP had the highest adjusted BMDs (0.403 ± 0.054 g/cm2 ); women homozygous for the C-allele had the lowest (0.373 ± 0.042 g/cm2 ), and heterozygous individuals had intermediate scores (0.394 ± 0.056 g/cm2 ).
Conclusion: This polymorphism in LIFR may be an important determinant of predisposition to postmenopausal osteoporosis. 相似文献
Methods: To investigate a potentially predisposing genetic factor in the onset of osteoporosis, we looked for a possible association between BMD in adult Japanese women and known polymorphisms in the leukemia inhibitory factor receptor gene (LIFR).
Results: An association analysis of chromosomes from 384 volunteer subjects revealed significant correlation between the −603T > C variant of LIFR and radial BMD ( r = 0.11, P = 0.032) in this test population. Comparisons of mean values of adjusted radial BMD among separate genotypic groups implied an allelic dosage effect, because homozygous carriers of T alleles of that SNP had the highest adjusted BMDs (0.403 ± 0.054 g/cm
Conclusion: This polymorphism in LIFR may be an important determinant of predisposition to postmenopausal osteoporosis. 相似文献
9.