全文获取类型
收费全文 | 3405篇 |
免费 | 176篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 128篇 |
儿科学 | 231篇 |
妇产科学 | 125篇 |
基础医学 | 203篇 |
口腔科学 | 126篇 |
临床医学 | 261篇 |
内科学 | 767篇 |
皮肤病学 | 73篇 |
神经病学 | 220篇 |
特种医学 | 103篇 |
外科学 | 855篇 |
综合类 | 59篇 |
一般理论 | 1篇 |
预防医学 | 86篇 |
眼科学 | 131篇 |
药学 | 133篇 |
中国医学 | 10篇 |
肿瘤学 | 107篇 |
出版年
2024年 | 1篇 |
2023年 | 18篇 |
2022年 | 34篇 |
2021年 | 73篇 |
2020年 | 40篇 |
2019年 | 61篇 |
2018年 | 86篇 |
2017年 | 66篇 |
2016年 | 117篇 |
2015年 | 184篇 |
2014年 | 164篇 |
2013年 | 204篇 |
2012年 | 268篇 |
2011年 | 262篇 |
2010年 | 157篇 |
2009年 | 129篇 |
2008年 | 253篇 |
2007年 | 272篇 |
2006年 | 277篇 |
2005年 | 259篇 |
2004年 | 258篇 |
2003年 | 157篇 |
2002年 | 141篇 |
2001年 | 27篇 |
2000年 | 21篇 |
1999年 | 15篇 |
1998年 | 6篇 |
1997年 | 9篇 |
1996年 | 14篇 |
1995年 | 11篇 |
1994年 | 9篇 |
1993年 | 2篇 |
1992年 | 6篇 |
1991年 | 1篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1985年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1967年 | 1篇 |
1959年 | 1篇 |
1934年 | 1篇 |
排序方式: 共有3619条查询结果,搜索用时 15 毫秒
1.
2.
Volume control associated with better cardiac function in long-term peritoneal dialysis patients. 总被引:4,自引:0,他引:4
Gulay A?ci Mehmet Ozkahya Soner Duman Huseyin Toz Sinan Erten Ercan Ok 《Peritoneal dialysis international》2006,26(1):85-88
BACKGROUND: This study was undertaken to investigate the effect of long-term blood pressure (BP) reduction, achieved with salt restriction and strict volume control, on frequency and regression of left ventricular hypertrophy (LVH) in long-term peritoneal dialysis (PD) patients. METHODS: 56 patients who had been treated for more than 2 years under our care were enrolled. After echocardiographic (Echo) evaluation, 46 patients were included in the follow-up study. In our unit, we aim to keep patients' BP below 130/85 mmHg and cardiothoracic index below 0.50. To reach these targets, moderate salt restriction is advised, and if necessary, hypertonic PD solutions are used. Echo was performed at the beginning of the study (after a mean period of 36 months on PD) and at the end of the prospective follow-up period (24 months later). RESULTS: At the time of the first Echo, LVH was detected in only 8 (21%) patients. Residual urine volume was significantly decreased compared to data taken when they first started PD (658 +/- 795 vs 236 +/- 307 mL/day). Mean left ventricular mass index (LVMI) was 107 +/- 26.5 g/m2. LVMI was significantly decreased at the end of the follow-up in patients who had LVH at baseline. No LVH developed in patients who had normal LVMI at baseline. CONCLUSION: Our results indicate that control of hypertension is possible when extracellular fluid volume is kept under control using hypertonic PD solutions in case of recruitment in addition to salt restriction in long-term PD patients. Sustained normovolemia is associated with low incidence and regression of LVH. 相似文献
3.
Hidir Esme MD Huseyin Fidan MD Ahmet Cekirdekci MD 《Indian Journal of Thoracic and Cardiovascular Surgery》2006,22(2):137-140
Background Hydatid disease is the most severe helminthic zoonosis, with an important public health problem especially in rural areas
in Turkey. The aim of this study was to review the problems and advantages encountered in surgical treatment of 43 patients
who were ventilated with one-lung ventilation during last four years.
Methods Patients, operated with one-lung ventilation, constitute the study group. Data related to symptoms, radiographic findings,
performed surgical procedures, perioperative and postoperative morbidity, hospitalization time, and cyst recurrence were collected
from each individual's records.
Results Cystotomy and capitonnage were performed in all cases. Perioperative complications were seen in 5 patients. Four of these
5 patients had double-lumen endotracheal tube malpositioning. In one patient hypoxemia developed. The most common postoperative
complication was atelectasis. One patient had recurrent cysts. There was no perioperative or postoperative death.
Conclusions We prefer cystotomy and capitonnage because it is a fast and effective technique with limited postoperative complications.
One-lung ventilation prevents the exposure of lower lung areas from massive aspiration, which may cause acute obstruction
of airways, and contamination by cyst contents from the operative part of the lung that causes recurrent disease. One-lung
ventilation in pulmonary hydatid cyst surgery may be preferred owing to lower mortality and morbidity rates. 相似文献
4.
5.
Osman Inci Esat Kaya Bulent Alagol Irfan Huseyin Atakan Sabahattin Aydin Hasan Ereselli 《International urology and nephrology》2003,36(1):1-4
Methods: Second primary cancers constitute approximately 9–10% of malignancies diagnosed in the United States. We aimed to show the
risk and incidance of second primary tumor occuring associated to urologic tumors and show the distrubution of tumors in Tracia
region. We retrospectively examined the patients' files with the diagnosis of malignant disease between the years 1985–2000.
Hazard function analysis was performed to estimate the relative risk of secondary malignancy occuring. Age, sex and tumor
number were examined to find out if they affect on mortality rate. Results: A total number of 25 MPMNs were diagnosed. In 52 percent of the cases the second primary neoplasm developed within six months.
The relative risk of development of a second neoplasm is found as increasing 1.111 times per month. The incidence of secondary
malignancy occuring in the patients with one tumor was found as 6.31%. Age (p < 0.001) and tumor number (p < 0.001) are found as statistically effective predictor on mortality rate where the sex is not. Conclusions: In the patients with a primary tumor not only the metastasis must be investigated but also second primary tumors should be
taken in to consideration.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
6.
Ulver DERICI Erdal KAN Dilek ERTOY Turgay ARINSOY Ayse DURSUN Zerrin BICIK Sukru SINDEL 《Nephrology (Carlton, Vic.)》2002,7(3):155-157
SUMMARY: Renal involvement is not uncommon in rheumatoid arthritis (RA). Many RA patients have renal dysfunction either secondary to the drugs used to treat arthritis or because of the chronic inflammation. Renal pathologies have often included amyloidosis, drug-related renal disease and mesangial glomerulonephritis. However, membranoproliferative glomerulonephritis has only been rarely reported. We report a case of rheumatoid arthritis associated with membranoproliferative glomerulonephritis that rapidly progressed to end-stage renal disease. 相似文献
7.
Alp İ. Göçer M. D. Erdal Çetinalp Metin Tuna Faruk İldan Hüseyin Bağdatoğlu Sebabattin Haciyakupoğlu 《Neurosurgical review》1997,20(2):114-116
The results of percutaneous radiofrequency rhizotomy of lumbar spinal facets in 46 patients followed at least three months (mean 15 months) are reported and compared with those reported previously. Satisfactory pain relief three months after the procedure was achieved in 36.4 percent of patients without operations and in 41.7 percent of patients with operations other than fusion.No patient had previously undergone fusion.Treatment of low-back pain by using radio-frequency thermocoagulation of spinal facets is a simple, safe, and well-tolerated procedure. It can be used to relief of pain in spite of decreasing rates of success within the follow-up period. 相似文献
8.
Kadir Baykal Sükrü Yildirim Haluk Inal Erdal Kalci Selami Albayrak Hakan Cingil Yavuz Önol 《International journal of urology》1997,4(1):104-105
Metastatic carcinoma to the testis is very rare. Metastasis of prostate adenocarcinoma to testis was detected incidentally after bilateral orchiectomy for hormonal management of metastatic prostate carcinoma. The metastatic lesion was not identified in physical examination or in macroscopic dissection of the testis after surgery. Microscopy revealed an adenocarcinoma which, given the history of the patient and a positive immunohistochemical stain for PSA, was identified as metastatic prostatic adenocarcinoma. 相似文献
9.
Alper Alkan Erdal Erdem Omer Günhan Cimen Karasu 《Journal of oral and maxillofacial surgery》2002,60(8):898-904
PURPOSE: Bone healing is impaired in diabetes mellitus, particularly due to increased collagen breakdown. Recently, tetracyclines have been used to treat experimental bone defects because they have anticollagenolytic properties, and positive effects on the healing process have been obtained. The objective of this study was to develop a computer-assisted histomorphometric technique to quantitatively determine the amount of regenerating bone within experimental bone defects in a diabetic rodent model. MATERIALS AND METHODS: This study examined the effects of systemic doxycycline administration on the healing of tibial bone defects in healthy albino rats and in experimentally induced diabetic rats. Twenty-four female albino rats were assigned to 4 groups: diabetic, diabetic plus doxycycline, control, or control plus doxycycline. The standardized bone defects were histomorphometrically examined 10 and 30 days postoperatively. Histomorphometric analysis of the amount of new bone formation was performed using the Zeiss Vision image analysis program KS 400 (Kontron Elektron GmbH, Eching, Germany). RESULTS: At 10 days of healing, the diabetic groups exhibited inferior healing compared with the control groups in terms of the amount of new bone formation within the defects. However, the effect of doxycycline administration to the diabetic and control groups was not statistically different. At 30 days of healing, there were no statistically significant differences between the amount of newly formed bone in any of the groups. CONCLUSIONS: This study found that doxycycline administration did not significantly alter the amount of new bone formation during the healing of bone defects in control and diabetic rats. 相似文献
10.
Mahmut Koç Ömer Yoldaş Yusuf Alper Kılıç Erdal Göçmen Tamer Ertan Hayrettin Dizen Mesut Tez 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2007,392(5):581-585
Background and aims The aim of this study is to evaluate the predictive accuracy of different scoring systems on surgery for perforated peptic
ulcer referred to an academic department of general surgery in a tertiary reference center.
Patients and methods Seventy-five consecutive patients (Male/female ratio = 64:11; mean age, 44 years; range, 16–85) with perforated peptic ulcer
disease were investigated. Disease severity scores and mortality predictions were calculated using the collected data during
admission. Discrimination and calibration characteristics of each system, namely, the acute physiology and chronic health
evaluation II and III, the simplified acute physiology score II, and the mortality probability models (MPM) II, were determined
by using the area under receiver operating characteristics curve and the Hosmer–Lemeshow goodness-of-fit test, respectively.
Results Among the 75 patients included, there were eight (10.6%) mortalities. All systems had a reliable power of discrimination and
calibration. Among the systems tested, MPM II was the best performing as far as discrimination and calibration characteristics
were considered. The parameters of MPM II system that were related to systemic perfusion of the patient were significantly
positive in patients who died compared to those who survived.
Conclusions MPM II that predicted mortality at admission is better than the other systems in predicting mortality. Results also indicate
the importance of maintenance of systemic perfusion of the patient at the early phases of peptic ulcer perforation. 相似文献