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Hans-Robert Metelmann Peter Hyckel Fred Podmelle 《Journal of cranio-maxillo-facial surgery》2012,40(2):103-104
Treating a patient suffering from an advanced oral cavity carcinoma by peritumoural injections of mistletoe preparation resulted in a surprising partial response. At the same time an early metastasis, located at the kidney, however remained unaffected. The main difference in treatment being peritumoural versus systematic application supports the hypothesis of immune surveillance. The impact of mistletoe extract in direct contact with the tumour tissue might be explained as activation of macrophage polarization followed by induced cytotoxicity. No direct contact is resulting in no direct macrophage activation. At present there is no clinical trial outlined to test this hypothesis, but as a beginning we would like to encourage submission of case reports with similar clinical experience. 相似文献
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Dr. J. G?tz C. Baier H.R. Springorum S. Anders J. Grifka G. Heers 《Zeitschrift für Rheumatologie》2012,71(8):658-669
This article gives an overview of the indications for operative treatment and the respective post-treatment of rheumatic elbows. The goal should be to preserve the function of the elbow joint and freedom from symptoms to prevent joint destruction which unfortunately can still be seen nowadays. 相似文献
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H. R. Springorum C. Baier J. Götz T. Schwarz A. Benditz J. Grifka G. Heers 《Der Orthop?de》2016,45(12):1083-1098
The wrist and hand form a highly complex organ that is of great importance in almost all daily activities. The hand serves as a tool and an organ of sense. Injuries of the hand and wrist as well as mechanical, neurological or systemic inflammatory changes are common. Taking a detailed history can already lead to a diagnosis. Almost all structures of the hand are easily accessible for clinical examination, i.?e. inspection, palpation and clinical tests, including dynamic testing. Diagnostic imaging completes the examination procedure. 相似文献
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Markus Weber Michael L. Woerner Hans-Robert Springorum Alexander Hapfelmeier Joachim Grifka Tobias F. Renkawitz 《The Journal of arthroplasty》2014
Successful biomechanical reconstruction is a major goal in total hip arthroplasty (THA). We measured leg length (LL), global (GO) and femoral offset (FO) change on anteroposterior pelvis radiographs and on three-dimensional computed-tomography (3D-CT) with fiducial landmarks after cementless THA on 18 hips of cadaveric specimens. Measurements on radiographs were performed twice by four examiners and showed high interobserver (mean CCC ≥ 0.79) and intraobserver agreements (mean ICC ≥ 0.88). Mean differences between radiographic and 3D-CT measurements were 1.0 (SD 2.0) mm for LL, 0.6 (SD 3.6) mm for GO and 1.4 (SD 5.2) mm for FO. 1% of radiographic LL-, 15% of GO- and 35% of FO measurements were outside a tolerance limit of 5 mm. Radiographs seem acceptable for measuring LL/GO change but fail to reflect FO change in THA. 相似文献
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Armin Keshmiri MD Günther Maderbacher Clemens Baier Werner MüllerHans Robert Springorum MD 《The Journal of arthroplasty》2014
Despite different surgical patellar interventions, the decision how to treat the patella during TKA remains controversial. The purpose of this study was to quantify the effect of different reconstructive patellar interventions on patellar kinematics during TKA using optical computer navigation. We implanted ten navigated TKAs in full body specimens. During passive motion, the effect of different surgical patellar interventions on patellar kinematics was analysed. A contrarily tilt behaviour was observed in the TKA group without patellar intervention compared to the natural knee. Lateral release led to similar tilt values (P < 0.05). All surgical interventions led to a 3 to 5 mm medial shift of the patella (P < 0.05). None of the analysed surgical patellar interventions could restore natural patellar kinematics after TKA. 相似文献
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J. Beckmann R. Springorum E. Vettorazzi S. Bachmeier C. Lüring M. Tingart K. Püschel O. Stark J. Grifka T. Gehrke M. Amling M. Gebauer 《Journal of orthopaedic research》2011,29(11):1753-1758
The prevention of hip fractures is a desirable goal to reduce morbidity, mortality, and socio‐economic burden. We evaluated the influence on femoral strength of different clinically applicable cementing techniques as “femoroplasty.” Twenty‐eight human cadaveric femora were augmented by means of four clinically applicable percutaneous cementing techniques and then tested biomechanically against their native contralateral control to determine fracture strength in an established biomechanical model mimicking a fall on the greater trochanter. The energy applied until fracture could be significantly increased by two of the methods by 160% (53.1 Nm vs. 20.4 Nm, p < 0.001) and 164% (47.1 Nm vs. 17.8 Nm, p = 0.008), respectively. The peak load to failure was significantly increased by three of the methods by 23% (3818.3 N vs. 3095.7 N, p = 0.003), 35% (3698.4 N vs. 2737.5 N, p = 0.007), and 12% (3056.8 N vs. 2742.8 N, p = 0.005), respectively. The femora augmented with cemented double drill holes had a lower fracture strength than the single drilled ones. Experimental femoroplasty is a technically feasible procedure for the prophylactic reinforcement of the osteoporotic proximal femur and, hence, could be an auxiliary treatment option to protect the proximal femur against osteoporotic fractures. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29:1753–1758, 2011 相似文献
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