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1.
JIA-LIN YANG PHILIP J CROWE KIM T OW JOHN M HAM ROGER L CROUCH PAMELA J RUSSELL 《Journal of gastroenterology and hepatology》1996,11(4):319-324
The most common cause of death in patients with colorectal cancer is metastatic liver disease. In order to identify patients at a high risk of developing hepatic secondaries from colorectal cancers, DNA content was measured in metastasizing colorectal primaries (Group I, n= 32) as well as in their subsequently resected liver secondaries and in sections of non-metastasizing colorectal cancers (Group II, n= 25). A modified interpretation system involving both a DNA index and percentage of cycling cells (those in S and G2 + M phases) was developed. DNA content was measured in paraffin-embedded sections by flow cytometry using internal controls (human peripheral blood mononuclear cells) and non-malignant tissue controls (19 patients with diverticular disease). In Group I there were significantly more tumours with both abnormal ploidy (aneuploid or abnormal tetraploid peak) and > 15% cycling cells compared with Group II (Chi-squared; P= 0.034). The combination of abnormal ploidy and > 15% cycling cells was superior to Dukes’ classification for identifying metastasizing tumours (Logistic Regression; P= 0.047). However, it was not possible to discriminate between the two groups using either DNA ploidy or the percentage of cycling cells alone. The metastasizing colorectal cancers exhibited similar DNA ploidy characteristics and had a similar percentage of cycling cells compared with their liver metastases. These results suggest that tumour DNA ploidy plus the percentage of cycling cells may predict the development of liver metastases and thus survival in patients with colorectal cancer. 相似文献
2.
ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome 总被引:11,自引:3,他引:11
Picketts DJ; Higgs DR; Bachoo S; Blake DJ; Quarrell OW; Gibbons RJ 《Human molecular genetics》1996,5(12):1899-1907
It was shown recently that mutations of the ATRX gene give rise to a
severe, X-linked form of syndromal mental retardation associated with alpha
thalassaemia (ATR-X syndrome). In this study, we have characterised the
full-length cDNA and predicted structure of the ATRX protein. Comparative
analysis shows that it is an entirely new member of the SNF2 subgroup of a
superfamily of proteins with similar ATPase and helicase domains. ATRX
probably acts as a regulator of gene expression. Definition of its genomic
structure enabled us to identify four novel splicing defects by screening
52 affected individuals. Correlation between these and previously
identified mutations with variations in the ATR-X phenotype provides
insights into the pathophysiology of this disease and the normal role of
the ATRX protein in vivo.
相似文献
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Marco Bandini Maarten Albersen Juan Chipollini Filippo Pederzoli Yao Zhu Ding-Wei Ye Antonio A. Ornellas Nick Watkin Michael Ager Oliver W. Hakenberg Axel Heidenreich Daniele Raggi Mario Catanzaro Friederike Haidl Elio Mazzone Laura Marandino Alberto Briganti Francesco Montorsi Mounsif Azizi Philippe E. Spiess Andrea Necchi 《BJU international》2020,125(6):867-875
8.
The 95th anniversary of the anatomist Friedrich Berthold Reinke’s death is 19 May 2014. This an excellent moment to remember his anatomical research. Two structures which he discovered and first described continue to be associated with his name: Reinke crystals of testicular Leydig cells and Reinke’s space in the larynx. Reinke’s crystals are crystalline protein aggregates within interstitial Leydig cells which are probably associated with testosterone production. They are pathognomonic for Leydig cell tumours. 相似文献
9.
In recent years, a definite change towards organ-sparing, reconstructive local treatment of penile cancer has been observed. Surgical treatment aims to achieve margin-free resections with risk-adapted much smaller safety margins. Thus, the penile structures are preserved as far as possible or reconstructed in order to achieve a functionally and cosmetically satisfactory result. The oncological safety concerning tumor-free survival is not compromised. However, a higher rate of local recurrences has to be accepted. 相似文献
10.
Martin Schoenthaler Noor Buchholz Erik Farin Hammad Ather Christian Bach Thorsten Bach John D. Denstedt Hans-Martin Fritsche Michael Grasso Oliver W. Hakenberg Ralf Herwig Thomas Knoll Franklin Emmanuel Kuehhas Evangelos Liatsikos Peter Liske Michael Marberger Palle J. S. Osther José Manuel Reis Santos Kemal Sarica Christian Seitz Michael Straub Olivier Traxer Alberto Trinchieri Ben Turney Arkadiusz Miernik 《World journal of urology》2014,32(4):1033-1040