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Treatment Failure With Rhythm and Rate Control Strategies in Patients With Atrial Fibrillation and Congestive Heart Failure: An AF‐CHF Substudy 下载免费PDF全文
KATIA DYRDA M.D. M.Sc. DENIS ROY M.D. HUGUES LEDUC M.Sc. MARIO TALAJIC M.D. LYNNE WARNER STEVENSON M.D. PETER G. GUERRA M.D. JASON ANDRADE M.D. MARC DUBUC M.D. LAURENT MACLE M.D. BERNARD THIBAULT M.D. LENA RIVARD M.D. PAUL KHAIRY M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2015,26(12):1327-1332
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Short-term administration of the H2-antagonist cimetidine (400 mg three times/day for 5 days) was performed in eight healthy male volunteers and its effects on both thyroid hormone levels and on hypophyseal hormone release induced by acute hypoglycaemia and TRH were tested. Absolute values of basal and post-TRH serum T3 were decreased by treatment, while basal and stimulated serum rT3 and T4 levels were not altered significantly. Cimetidine administration did not change the hormone release induced by acute hypoglycaemia but significantly enhanced the prolactin and TSH responses to TRH. Our results suggest that cimetidine administration can modify the peripheral metabolism rather than the secretion of thyroid hormones. 相似文献