全文获取类型
收费全文 | 2040篇 |
免费 | 124篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 71篇 |
妇产科学 | 67篇 |
基础医学 | 242篇 |
口腔科学 | 45篇 |
临床医学 | 109篇 |
内科学 | 566篇 |
皮肤病学 | 35篇 |
神经病学 | 114篇 |
特种医学 | 113篇 |
外科学 | 382篇 |
综合类 | 21篇 |
预防医学 | 162篇 |
眼科学 | 24篇 |
药学 | 85篇 |
中国医学 | 6篇 |
肿瘤学 | 127篇 |
出版年
2023年 | 15篇 |
2022年 | 22篇 |
2021年 | 67篇 |
2020年 | 45篇 |
2019年 | 38篇 |
2018年 | 57篇 |
2017年 | 39篇 |
2016年 | 55篇 |
2015年 | 54篇 |
2014年 | 54篇 |
2013年 | 91篇 |
2012年 | 113篇 |
2011年 | 132篇 |
2010年 | 78篇 |
2009年 | 67篇 |
2008年 | 124篇 |
2007年 | 106篇 |
2006年 | 89篇 |
2005年 | 113篇 |
2004年 | 89篇 |
2003年 | 81篇 |
2002年 | 80篇 |
2001年 | 42篇 |
2000年 | 27篇 |
1999年 | 50篇 |
1998年 | 34篇 |
1997年 | 32篇 |
1996年 | 35篇 |
1995年 | 32篇 |
1994年 | 24篇 |
1993年 | 19篇 |
1992年 | 31篇 |
1991年 | 20篇 |
1990年 | 20篇 |
1989年 | 19篇 |
1988年 | 21篇 |
1987年 | 12篇 |
1986年 | 18篇 |
1985年 | 17篇 |
1984年 | 16篇 |
1983年 | 10篇 |
1982年 | 8篇 |
1981年 | 15篇 |
1980年 | 12篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1977年 | 7篇 |
1976年 | 7篇 |
1974年 | 5篇 |
1964年 | 3篇 |
排序方式: 共有2184条查询结果,搜索用时 15 毫秒
1.
2.
Yolanda Carrascal PhD Gregorio Laguna PhD Miriam Blanco MD Bárbara Segura MD Iciar Martínez-Almeida MD 《Journal of cardiac surgery》2020,35(2):457-459
Gray platelet syndrome (GPS) is a rare (<1/1 000 000) and inherited platelet function disorder characterized by macrothrombocytopenia, α-granule deficiency, and hemorrhages. Bleeding intensity does not correlate with platelet count nor with functional test results. We hereby describe the perioperative bleeding prevention and management of a patient with GPS requiring multiple redo cardiac surgeries. 相似文献
3.
MEMRI and tumors: a method for the evaluation of the contribution of Mn(II) ions in the extracellular compartment
下载免费PDF全文
![点击此处可从《NMR in biomedicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Eliana Gianolio Francesca Arena Enza Di Gregorio Roberto Pagliarin Martina Delbianco Gabriella Baio Silvio Aime 《NMR in biomedicine》2015,28(9):1104-1110
The purpose of the work was to set‐up a simple method to evaluate the contribution of Mn2+ ions in the intra‐ and extracellular tumor compartments in a MEMRI experiment. This task has been tackled by “silencing” the relaxation enhancement arising from Mn2+ ions in the extracellular space. In vitro relaxometric measurements allowed assessment of the sequestering activity of DO2A (1,4,7,10‐tetraazacyclododecane‐1,7‐diacetic acid) towards Mn2+ ions, as the addition of Ca‐DO2A to a solution of MnCl2 causes a drop of relaxivity upon the formation of the highly stable and low‐relaxivity Mn‐DO2A. It has been proved that the sequestering ability of DO2A towards Mn2+ ions is also fully effective in the presence of serum albumin. Moreover, it has been shown that Mn‐DO2A does not enter cell membranes, nor does the presence of Ca‐DO2A in the extracellular space prompt migration of Mn ions from the intracellular compartment. On this basis the in vivo, instantaneous, drop in SE% (percent signal enhancement) in T1‐weighted images is taken as evidence of the sequestration of extracellular Mn2+ ions upon addition of Ca‐DO2A. By applying the method to B16F10 tumor bearing mice, T1 decrease is readily detected in the tumor region, whereas a negligible change in SE% is observed in kidneys, liver and muscle. The relaxometric MRI results have been validated by ICP‐MS measurements. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
4.
5.
Patients with Fabry disease on dialysis in the United States. 总被引:9,自引:0,他引:9
Ravi Thadhani Myles Wolf Michael L West Marcello Tonelli Robin Ruthazer Gregory M Pastores Gregorio T Obrador 《Kidney international》2002,61(1):249-255
BACKGROUND.: Fabry disease results from an X-linked deficiency of lysosomal alpha-galactosidase A and is a rare cause of end-stage renal disease. Little is known about the characteristics of patients with Fabry disease that initiate dialysis in the United States, although data from Europe suggests these individuals have a poor survival. METHODS.: Using the United States Renal Disease System database, we first studied in detail 42 Fabry patients who initiated dialysis between April 1995 (following the introduction of the new detailed HCFA 2728 form) and July 1998. To examine crude survival in a larger cohort, 95 Fabry patients were studied who initiated dialysis between 1985 and 1993, similar to the European Registry. Diabetic and non-diabetic controls matched by age, gender, race, year of dialysis initiation, and initial dialysis modality were examined for comparison. RESULTS.: During the years 1995 to 1998, the mean age of Fabry patients that initiated dialysis was 42 years, 83% were Caucasian, and 10% were African American. Despite the X-linked inheritance of Fabry disease, 12% of Fabry patients on dialysis were female. At initiation of dialysis mean serum albumin and creatinine were significantly higher and mean body mass index was significantly lower among Fabry patients, but mean glomerular filtration rate was similar to controls. Fabry patients tended to have a lower three-year survival compared to non-diabetic controls, but the results were not significantly different. In a larger cohort of Fabry patients who initiated dialysis between 1985 and 1993, the three-year survival of Fabry patients was significantly lower than non-diabetic controls: 63% (95% CI, 50 to 75%) versus 74% (95% CI, 67 to 80%; P=0.03). CONCLUSION.: End-stage renal disease is associated with significant morbidity and mortality among patients with Fabry disease. Recent evidence that progression of Fabry disease may be attenuated by enzyme replacement therapy necessitates increased awareness of Fabry disease and its comorbidities. 相似文献
6.
7.
Gregorio S. Santos MD Ara Sadaniantz MD 《American journal of obstetrics and gynecology》1997,177(6):1553-1555
We report a postpartum acute myocardial infarction that occurred during the first week after cesarean section delivery. We also calculated the rate of postpartum myocardial infarction as related to all women with myocardial infarctions seen in our hospital.(Am J Obstet Gynecol 1997;177:1553-5.) 相似文献
8.
9.
Significance of extractable nuclear antigens in childhood autoimmune liver disease. 总被引:2,自引:0,他引:2
下载免费PDF全文
![点击此处可从《Clinical and experimental immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
G V Gregorio E T Davies G Mieli-Vergani D Vergani 《Clinical and experimental immunology》1995,102(2):308-313
The relative virulence of different isolates of Mycobacterium avium has been linked to their capacity to trigger the secretion of TNF from the macrophages they infect. Smooth opaque (SmOp) variants of Myco. avium have been shown to trigger higher expression of TNF-alpha by macrophages in vitro than the smooth transparent (SmTr) variants. To analyse the role of TNF in resistance to infection by Myco. avium, we studied the infection by two different morphotypes of strain 2.151 of Myco. avium both in vitro and in vivo in the presence or absence of neutralizing antibodies to TNF. No effects were found in vitro regarding the growth of either isolate of Myco. avium. In vivo, only the virulent SmTr morphotype showed enhanced growth in the presence of the neutralizing antibodies. This enhancement occurred relatively late when priming for TNF secretion in vivo was evident. Among four isolates of Myco. avium, three virulent ones induced a marked priming for TNF release and one avirulent strain did not. Mycobacterium tuberculosis H37Ra, which is very active in inducing TNF release due to its lipoarabinomannan moiety, was used to compare with the previous results. The growth of H37Ra in macrophages was increased in vitro by the neutralization of TNF and neutralization of either TNF and/or interferon-gamma (IFN-gamma) enhanced the in vivo proliferation of this microbe in the spleen and liver of infected animals, whereas only the combination of both anti-TNF and anti-IFN-gamma enhanced bacterial proliferation in the lung. We conclude that resistance to the avirulent strains of Myco. avium did not involve TNF, but rather antimicrobial mechanisms expressed constitutively in the mononuclear phagocytes. In contrast, TNF plays an important role in the control of Myco. tuberculosis H37Ra infection. 相似文献
10.