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1.
Terry?O?Herndon Salvador?Gonzalez TR?Gowrishankar R?Rox?Anderson James?C?WeaverEmail author 《BMC medicine》2004,2(1):12
Background
Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum and epidermis is achieved by stochastic scissioning events localized to typically 250 μm diameter areas of human skin in vivo. 相似文献2.
Benjamin F. Ricciardi Gowrishankar Muthukrishnan Elysia Masters Mark Ninomiya Charles C. Lee Edward M. Schwarz 《Current reviews in musculoskeletal medicine》2018,11(3):389-400
Purpose of Review
The incidence of complications from prosthetic joint infection (PJI) is increasing, and treatment failure remains high. We review the current literature with a focus on Staphylococcus aureus pathogenesis and biofilm, as well as treatment challenges, and novel therapeutic strategies.Recent Findings
S. aureus biofilm creates a favorable environment that increases antibiotic resistance, impairs host immunity, and increases tolerance to nutritional deprivation. Secreted proteins from bacterial cells within the biofilm and the quorum-sensing agr system contribute to immune evasion. Additional immunoevasive properties of S. aureus include the formation of staphylococcal abscess communities (SACs) and canalicular invasion. Novel approaches to target biofilm and increase resistance to implant colonization include novel antibiotic therapy, immunotherapy, and local implant treatments.Summary
Challenges remain given the diverse mechanisms developed by S. aureus to alter the host immune responses. Further understanding of these processes should provide novel therapeutic mechanisms to enhance eradication after PJI.3.
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A protein binding the methylated 5''-terminal sequence, m7GpppN, of eukaryotic messenger RNA. 总被引:6,自引:0,他引:6 下载免费PDF全文
W Filipowicz Y Furuichi J M Sierra S Muthukrishnan A J Shatkin S Ochoa 《Proceedings of the National Academy of Sciences of the United States of America》1976,73(5):1559-1563
Ribosomal salt washes of Artemia salina embryos contain a protein(s) that binds [3H]m7GpppGpC and [3H]m7GpppGmpC, as measured by retention on nitrocellulose membrane filters. These oligonucleotides correspond in structure to the methylated 5'-terminal sequences (caps) present in many eukaryotic mRNAs. The cap binding protein does not bind the unmethylated counterparts of caps, e.g., [32P]GpppGpCp, or a derivative of m7GpppGmpC containing ring-opened m7G. None of the purified initiation factors IF-MP, IF-M2A, IF-M2B, IF-M3, or IF-MI binds the m7G-containing oligonucleotides. 相似文献
7.
B. S. Vachan Aishwarya Ramesh Muthu Karuppasamy Isravel Muthukrishnan Subbiah Nagarajan J. Carlos Menndez C. Uma Maheswari Vellaisamy Sridharan 《RSC advances》2019,9(57):32946
An oxidant-free three-component synthesis of biologically significant 7-amino-6H-benzo[c]chromen-6-ones was established involving a Sc(OTf)3 catalyzed three-component reaction between primary amines, β-ketoesters and 2-hydroxychalcones under green conditions. In this strategy, both the B and C rings of 6H-benzo[c]chromen-6-ones were constructed simultaneously starting from acyclic precursors by generating four new bonds including two C–C, one C–N and one C–O in a single synthetic operation. The mechanism of this sequential cascade process involves the initial formation of a β-enaminone intermediate followed by Michael addition with 2-hydroxychalcone, intramolecular cyclization, dehydration, lactonization and aromatization steps. Unlike the related literature approaches, this reaction delivered the products without the addition of any external oxidants to achieve the key aromatization step.Three-component synthesis of 7-amino-6H-benzo[c]chromen-6-ones was achieved under oxidant-free green conditions. 相似文献
8.
Gandham SriLakshmi Bhavani Hitesh Shah Ashwin B. Dalal Anju Shukla Sumita Danda Shagun Aggarwal Shubha R. Phadke Neerja Gupta Madhulika Kabra Kalpana Gowrishankar Anju Gupta Meenakshi Bhat Ratna D. Puri Sunita Bijarnia‐Mahay Sheela Nampoothiri Kavitha M. Mohanasundaram S. Rajeswari Akhil M. Kulkarni Muralidhar L. Kulkarni Prajnya Ranganath A. Radha Ramadevi Sankar V. Hariharan Katta Mohan Girisha 《American journal of medical genetics. Part A》2015,167(10):2481-2484
9.
One rare side effect of zolpidem--sleepwalking: a case report 总被引:3,自引:0,他引:3
Yang W Dollear M Muthukrishnan SR 《Archives of physical medicine and rehabilitation》2005,86(6):1265-1266
Zolpidem is an imidazopyridine agent indicated for the short-term treatment of insomnia. Sleepwalking is a rare side effect of zolpidem. A review of the literature produced only 2 cases. We report a case of a male rehabilitation inpatient in his mid fifties with a history of alcoholism and traumatic brain injury who had undergone a right hip hemiarthroplasty. He had no history of somnambulism or insomnia but walked in his sleep on 2 nonconsecutive nights after taking zolpidem. He had exhibited no such behavior before taking zolpidem, on the intervening night that was he was not given medication, and after the medication was discontinued. We conclude that zolpidem can cause sleepwalking, and patients who have suffered a brain injury may be more susceptible to this side effect. Here we describe the clinical presentation and review the relevant literature on zolpidem and sleepwalking. 相似文献
10.
Fibrodysplasia ossificans progressiva 总被引:1,自引:0,他引:1
Subramanyam L Gowrishankar K Shivbalan S Balachandran A 《Indian journal of pediatrics》2004,71(6):563-564
A 2-year-old boy presented with low-grade fever and multiple progressive painful swellings over upper dorsal trunk and supraclavicular
region with progressive stiffening of skin for the last 2 months. Examination revealed dysmorphic face, proximally placed
thumb and bilateral hallux valgus. Hence, a diagnosis of Fibrodysplasia Ossificans Progressiva was entertained 相似文献