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排序方式: 共有846条查询结果,搜索用时 218 毫秒
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Ulrich Weber Christian WA Pfirrmann Rudolf O Kissling Juerg Hodler Marco Zanetti 《BMC musculoskeletal disorders》2007,8(1):20
Background
Ankylosing spondylitis is a chronic inflammatory rheumatic disorder which usually begins in early adulthood. The diagnosis is often delayed by many years. MR imaging has become the preferred imaging method for detection of early inflammation of the axial skeleton in ankylosing spondylitis. 相似文献3.
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Jejunoileal bypass procedures for morbid obesity have been associated with numerous side effects, due mainly to the blind-loop syndrome. To overcome this, the authors describe a new procedure, ileogastrostomy, that they have performed in 50 patients. All had good weight loss and returned to work. Patient satisfaction with the operation was high and self-esteem increased. There were no deaths or severe complications. Stool frequency and foul-smelling stools were still problems but improved with time. Stomal ulceration occurred at 3 months in three patients but resolved within 1 month when treated with H2 blocking agents and was not encountered later than 3 months in any patient. 相似文献
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S. G. Gourlay N. L. Benowitz A. Forbes J. J. McNeil 《European journal of clinical pharmacology》1997,51(5):407-414
Objective: Interindividual variability in plasma concentrations of nicotine and its proximate metabolite, cotinine, is considerable
during smoking and transdermal nicotine treatment, even among individuals taking in nominally similar doses of nicotine. This
report explores the determinants of this variability and the utility of baseline (smoking) plasma concentrations to predict
concentrations during transdermal nicotine treatment.
Methods: Data were analysed from a smoking cessation study (n = 466), and from a pharmacokinetic study (n = 12). Multiple regression models examined the relationships of plasma concentrations to individual characteristics such
as smoking pattern, absorbed dose of nicotine, and pharmacokinetic parameters.
Results: Plasma concentrations of nicotine and cotinine were highly variable in both studies. Indirect estimates of plasma clearance
(baseline plasma concentration divided by cigarettes per day) together with other factors could account for 18 to 33% of the
variability during transdermal nicotine treatment in the smoking cessation study. In contrast, 75 to 99% was accounted for
by direct measurements of plasma clearances and systemic dose of nicotine in the pharmacokinetic study.
Conclusion: Plasma concentrations of nicotine and cotinine during transdermal nicotine treatment are poorly predicted by clinical history
or baseline plasma concentrations. This is a result of inadequate characterisation of highly variable individual pharmacokinetic
parameters and absorbed dose of nicotine. Considering the interindividual variability of plasma nicotine and cotinine concentrations
together with the lack of clinical end-points for transdermal nicotine dosing, it seems logical to investigate the utility
of a therapeutic drug monitoring approach for transdermal nicotine treatment – particularly for high dose regimens (> 22 mg
per 24 hours).
Received: 7 May 1996 / Accepted in revised form: 21 August 1996 相似文献
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C K Dingee I G Cleator J K MacFarlane R M Christensen C L Birmingham J Appleby R H Gourlay 《Canadian journal of surgery》1990,33(1):25-27
Patients who have had ileogastrostomy for the treatment of morbid obesity require close, long-term follow-up. From a prospective study of a large number of variables in 12 consecutive patients, and from experience with more than 200 patients who have undergone this procedure since 1982, a protocol has evolved. The authors outline the associated morbid conditions, operative complications and biochemical alterations that are important in the management of these patients. 相似文献
10.
The Pall LG6 arterial line filter has been designed to remove free circulating leukocytes from the arterial line of the extracorporeal circuit employed in openheart surgery. The filter was evaluated and compared to a control filter (Pall Stat-Prime) in terms of its general blood handling characteristics, particularly with regard to the associated level of leukocyte removal. The gross air handling characteristics of the filters were also assessed together with pressure drop. It was found that the filters differed little in terms of all factors studied other than the level of leukocyte depletion. The LG6 filter was associated with substantial levels of leukocyte depletion, particularly the depletion of neutrophils. Over the 90 minute perfusion period the LG6 filter was found to be associated with a neutrophil depletion rate of around 70% while preferentially sparing lymphocytes. This compared to a 10-20% depletion rate in the control filter. This was achieved without apparently compromising the performance of the filter in terms of the other factors studied. 相似文献