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氟喹诺酮类药物不良反应168例分析 总被引:12,自引:0,他引:12
0 引言 随着氟喹诺酮类药物在临床的广泛应用,有关其应用所致不良反应的报道也日趋增多,我们通过对1990/2003年我院氟喹诺酮类药物不良反应情况报告如下,供临床参考。 相似文献
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Hans-Georg Elias Daniel C. Chung Nobuo Donkai Goetz P. Hellmann Karel Solc Katsutoshi Nagai 《Macromolecular chemistry and physics.》1987,188(3):537-560
1-O-3-(4-Vinylphenyl)propyl-β-D -glucopyranose ( 1 ) undergoes in water a closed association under formation of N-mers. The unimer/N-mer association is directly visible in the Schlieren pattern of ultracentrifugal synthetic boundary experiments. Association numbers and mass-concentration-based equilibrium constants of association were calculated from the variation of N-mer concentrations with unimer concentrations and from the concentration dependence of inverse apparent average molar masses as measured by both vapor phase osmometry and sedimentation equilibrium. Association numbers were also calculated from the combination of sedimentation coefficients with diffusion coefficients, sedimentation coefficients with intrinsic viscosities, and diffusion coefficients with interinsic viscosities as well as from the dependence of apparent mass-average molar masses on inverse apparent number-average molar masses. All methods gave in general different association numbers and equilibrium constants. The effect, which was not found for other non-ionic amphiphiles, is probably due to the existence of consecutive equilibria between the unimer and a low molar mass P-mer which associates to a higher molar mass R-mer. Viscosity data are in agreement with the picture of a spherical micelle for the dominant P-mers with about 10 water molecules per glucose residue. The micellization of 1 is both enthalpy- and entropy-driven, in contrast to the micellization of 1-O-octyl-β-D -glucopyranose which is a strictly entropy-driven process. 相似文献
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Factors influencing women to undergo screening mammography 总被引:2,自引:0,他引:2
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The efficacy of betanecholchloride in the postoperative treatment of bladder dysfunction is controversial. We therefore performed
a comparative study on the effect of this therapy for the prophylaxis of detrusor hypotonia after Wertheim-Meigs operation.
Forty patients with cervical cancer FIGO stage Ib/IIa were divided into two study groups. The control group (24 patients)
only received betanecholchloride if the residual urine persisted above 50 ml after the 10th postoperative day. The study group
(16 patients) received 50 mg betanecholchloride three times a day from the 3rd postoperative day onward. In this group postoperative
catheter treatment, and consequently hospital stay, were significantly shorter (9.6 versus 13.3 days and 15.5 versus 18.6
days). The residual urinary volume normalized faster (8.0 versus 13.0 days) and the rate of cystitis was lower (18.8 versus
25%). According to our study, a prophylactic application of the parasympathomimetic drug betanecholchloride diminishes postoperative
complications associated with bladder dysfunction after Wertheim-Meigs operation.
EDITORIAL COMMENT: Bladder dysfunction plays an important role after radical hysterectomy. The authors present data indicating
improved and quicker resumption of bladder function following radical hysterectomy with early administration of betanecholchloride,
versus use of the medication only when indicated by elevated postvoid residual. Although the study is not a double-blinded
placebo-controlled trial, the patients who received beta-necholchloride from postoperative day 3 had significantly decreased
postoperative catheter treatment, earlier resumption of adequate bladder emptying defined as a postvoid residual of less than
50 ml, decreased incidence of bladder infection and shorter hospital stay. This information is encouraging for this subset
of patients, who characteristically are at high risk for long-term bladder dysfunction. Further studies in this area are needed
to clarify therapeutic options to improve patients’ quality of life, specifically in regard to bladder function following
treatment of their cancer. 相似文献
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Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin 总被引:2,自引:0,他引:2
MARIE LODÉN HÅKAN OLSSON TONY AXÉLL YLVA WERNER LINDE† 《The British journal of dermatology》1992,126(2):137-141
The biophysical properties of non-eczematous skin at three locations in atopics and non-atopics were characterized using non-invasive physical methods. Skin friction was measured with a newly developed sliding friction instrument, the degree of hydration with a capacitance meter (Corneometer CM 820), and the transepidermal water loss (TEWL) was determined using an Evaporimeter EP1. The areas examined (dorsum of the hand, volar forearm and lower back) showed lower values of friction and capacitance in the atopic patients than did corresponding sites in the normal controls. In most areas a significant correlation between friction and capacitance was found. The TEWL was increased in atopic skin, but TEWL seems to correlate neither to friction nor to capacitance. 相似文献