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1.
We evaluated centrilobular histologic changes seen on post-orthotopic liver transplantation (OLT) biopsies to refine the pathologic diagnosis by systematic study of morphologic and clinical data with possible identification of prognostic criteria. A total of 110 biopsies with zone 3 pathology from 59 patients were reviewed and correlated with clinical findings. Within the first 6 months post-OLT (group I), 39 of 47 patients had combinations of centrilobular hepatocytic dropout, ballooning, and cholestasis on single or multiple biopsies attributed to perioperative ischemic/perfusion injury; 12 of 39 patients with all 3 features present had increased incidence of biliary complications and sepsis and decreased 1-year patient and graft survival; 17 of 39 patients with 2 of the 3 features had increased biliary complications but not decreased 1-year survival; and the remaining 8 of 47 patients had central venulitis associated with acute cellular rejection. After 6 months post-OLT (group II), 14 patients, including 2 from group I, had biopsies with centrilobular pathology; 8 of 14 had central venulitis related to rejection (acute, 4; chronic, 4), and fibrosis was seen in 8 (rejection, 6; cardiac problems, 2). In conclusion, combinations of centrilobular hepatocytic ballooning, dropout, and cholestasis are seen in association with reversible or irreversible ischemic/perfusion damage in the early post-OLT period. The presence of all 3 features is associated with a poor outcome. Central venulitis as a feature of acute/chronic rejection is seen at any time post-OLT and is not a predictor of poor graft/patient survival. 相似文献
2.
Atike Gken Demiray Aydn Demiray Arzu Yaren Burcu Yapar Takylü Gamze Gkz Dou Serkan Deirmenciolu Umut akrolu Nail
zhan Canan Karan Burin akan Demirel Tolga Doan Melek
zdemir 《The Turkish journal of gastroenterology》2022,33(8):696
Background:First-line treatments for metastatic pancreatic cancer are chemotherapy regimens consisting of 5-fluorouracil or gemcitabine; however, there are no biomarkers to help determine which patients might benefit from which treatment regimens. We aimed to show that microRNAs let-7c and 7d can be used as independent predictive biomarkers for metastatic pancreatic cancer.Methods:A total of 55 patients who had first-line chemotherapy with FOLFIRINOX or gemcitabine + capecitabine were included. Patients were divided into groups based on let-7c and let-7d levels and chemotherapy treatment as let-7c-7d high FOLFIRINOX, let-7c-7d high gemcitabine + capecitabine, let-7c-7d low FOLFIRINOX, and let-7c-7d low gemcitabine + capecitabine. Blood samples were taken from patients before chemotherapy for microRNA let-7c and 7d analysis. MicroRNA isolation was performed using a miRNeasy Serum/Plasma Kit and identified using spectrophotometric measurements. After isolation, microRNA was converted to cDNA using a microRNA cDNA Synthesis Kit with poly (A) polymerase tailing. The expression of microRNA was examined using quantitative real-time polymerase chain reaction.Results:The overall survival of patients who received FOLFIRINOX treatment with a high let-7c-7d level was statistically significantly longer than those who received gemcitabine + capecitabine with a high let-7c-7d level. In addition, patients with low let-7c expression receiving FOLFIRINOX progressed significantly 2.104 times earlier than patients with high let-7c expression receiving FOLFIRINOX.Conclusion:The serum MicroRNA let-7c level was found to be an independent predictive biomarker in the FOLFIRINOX treatment group. 相似文献
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Goksel Cagirci M.D. Serkan Cay M.D. Ozlem Karakurt M.D. Neslihan Eryasar M.D. Veli Kaya M.D. Aytun Canga M.D. Asuman Bicer Yesilay M.D. Harun Kilic M.D. Serkan Topaloglu M.D. Dursun Aras M.D. Ahmet Duran Demir M.D. Ramazan Akdemir M.D. 《Annals of noninvasive electrocardiology》2009,14(4):327-332
Background: Cigarette smoking increases the risk of cardiovascular events related with several mechanisms. The most suggested mechanism is increased activity of sympathetic nervous system. Heart rate variability (HRV) and heart rate turbulence (HRT) has been shown to be independent and powerful predictors of mortality in a specific group of cardiac patients. The goal of this study was to assess the effect of heavy cigarette smoking on cardiac autonomic function using HRV and HRT analyses. Methods: Heavy cigarette smoking was defined as more than 20 cigarettes smoked per day. Heavy cigarette smokers, 69 subjects and nonsmokers 74 subjects (control group) were enrolled in this study. HRV and HRT analyses [turbulence onset (TO) and turbulence slope (TS)] were assessed from 24‐hour Holter recordings. Results: The values of TO were significantly higher in heavy cigarette smokers than control group (?1.150 ± 4.007 vs ?2.454 ± 2.796, P = 0.025, respectively), but values of TS were not statistically different between two groups (10.352 ± 7.670 vs 9.613 ± 7.245, P = 0.555, respectively). Also, the number of patients who had abnormal TO was significantly higher in heavy cigarette smokers than control group (23 vs 10, P = 0.006). TO was correlated with the number of cigarettes smoked per day (r = 0.235, P = 0.004). While LF and LF/HF ratio were significantly higher, standard deviation of all NN intervals (SDNN), standard deviation of the 5‐minute mean RR intervals (SDANN), root mean square of successive differences (RMSSD), and high‐frequency (HF) values were significantly lower in heavy smokers. While, there was significant correlation between TO and SDNN, SDANN, RMSSD, LF, and high frequency (HF), only HF was correlated with TS. Conclusion: Heavy cigarette smoking has negative effect on autonomic function. HRT is an appropriate noninvasive method to evaluate the effect of cigarette on autonomic function. Simultaneous abnormal HRT and HRV values may explain increased cardiovascular event risk in heavy cigarette smokers. 相似文献
6.
The aim of this trial was to investigate the effects of a 12-week home-based exercise program (HEP) on quality of life (QOL)
and fatigue in patients with Ankylosing Spondylitis (AS). Forty-three patients with AS were included in this study. Group
1 was given a HEP; Group 2 served as the control group. The functional capacity (Bath Ankylosing Spondylitis Functional Index),
disease activity (Bath Ankylosing Spondylitis Disease Assessment Index), fatigue (Multidimensional Assessment of Fatigue Scale),
depression (Beck Depression Inventory scores), and QOL (Short Form 36) of all participants were evaluated. There were significant
improvements for all the parameters in two groups after the treatment. The improvements for all the parameters were better
in the exercise group than in the control group. Home-based exercise programs are very effective in improving QOL and reducing
fatigue. Because of these advantages, HEP should be advised for the management program in AS in addition to medical treatments.
This study was presented at the 21st National Physical Medicine and Rehabilitation Congress, Antalya, Turkey, 24–29 September
2007. 相似文献
7.
Introduction
This study evaluated the cyclic fatigue resistance (CFR) of Reciproc (R25 and R40; VDW, Munich, Germany) and Reciproc Blue (R25 and R40, VDW) instruments used in an artificial S-shaped canal.Methods
A total of 80 files were tested in an S-shaped canal (n = 20 for each file, Reciproc R25 and R40 and Reciproc Blue R25 and R40). This study compared Reciproc R25 with Reciproc Blue R25 files and Reciproc R40 with Reciproc Blue R40 files. All files were rotated in an S-shaped artificial canal until fracture. CFR was determined by recording the time to fracture in the artificial canal. The length of each fractured fragment was measured in millimeters. An independent sample t test was used to analyze the data.Results
Between the R25 files, Reciproc Blue instruments showed significantly greater CFR than the Reciproc files in the apical and coronal curves (P < .05). Between the R40 files, Reciproc Blue instruments exhibited greater CFR in the apical and coronal curves (P < .05). There was no difference in the fractured fragment lengths of the Reciproc Blue files compared with the Reciproc files (P > .05).Conclusions
The Reciproc Blue R25 and R40 files showed greater CFR than the Reciproc R25 and R40 files in an S-shaped canal. 相似文献8.
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Guven Gamze Samanci Bedia Gulec Cagri Hanagasi Hasmet Gurvit Hakan Gokalp Ebru Erzurumluoglu Tepgec Fatih Guler Suleyman Uyguner Oya Bilgic Basar 《Neurological sciences》2021,42(6):2497-2504
Neurological Sciences - Alzheimer’s disease (AD) can be either sporadic or familial, and familial forms of AD accounts for only 5% of the cases. So far, autosomal dominantly inherited... 相似文献